Zobrazeno 1 - 10
of 48
pro vyhledávání: '"S S, Negus"'
Autor:
T. R. Baird, H. I. Akbarali, W. L. Dewey, H. Elder, M. Kang, S. A. Marsh, M. R. Peace, J. L. Poklis, E. J. Santos, S. S. Negus
Publikováno v:
Psychopharmacology (Berl)
RATIONALE: Tianeptine is a mu-opioid receptor (MOR) agonist with increasing reports of abuse in human populations. Preclinical data regarding the abuse potential and other opioid-like adverse effects of tianeptine at supratherapeutic doses are sparse
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(1)
Synthetic cannabinoids (SCs) represent an emerging class of abused drugs associated with psychiatric complications and other substantial health risks. These ligands are largely sold over the internet for human consumption, presumably because of their
Autor:
F, Sakloth, R, Kolanos, P D, Mosier, J S, Bonano, M L, Banks, J S, Partilla, M H, Baumann, S S, Negus, R A, Glennon
Publikováno v:
British journal of pharmacology. 172(9)
There is growing concern over the abuse of certain psychostimulant methcathinone (MCAT) analogues. This study extends an initial quantitative structure-activity relationship (QSAR) investigation that demonstrated important steric considerations of se
Publikováno v:
European Journal of Pharmacology. 298:31-36
The μ-opioid receptor antagonist effects of naloxonazine on levorphanol-induced thermal antinociception and respiratory depression were examined in rhesus monkeys. Levorphanol (0.032–3.2 mg/kg) produced dose-dependent increases in tail-withdrawal
Publikováno v:
Neuropharmacology. 31:1231-1241
The acute effects of opioid drugs are generally hypothesized to be mediated by multiple receptors, for which three types of binding sites have been established. In order to evaluate the selective participation of each type of opioid receptor in opiat
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
Tolerance and dependence after acute or chronic administration of the selective delta-opioid agonist SNC80 were assessed in rhesus monkeys (Macaca mulatta) responding under a schedule of food presentation. SNC80 dose dependently decreased response ra
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(3)
The effects of SNC80 and other structurally related delta-opioid receptor agonists were assessed under conditions of chemically induced hypersensitivity to thermal stimuli in four rhesus monkeys. The shaved tail of each monkey was exposed to warm wat
Publikováno v:
Experimental and clinical psychopharmacology. 8(3)
Effects of D1-like and D2-like agonists were compared in rats (Rattus norvegicus) with differing levels of experience (24 or 9 mo) in a cocaine discrimination procedure (5.6 mg/kg cocaine; fixed-ratio 20 schedule of food presentation). Cocaine, d-amp
Effects of kappa opioid agonists on the discriminative stimulus effects of cocaine in rhesus monkeys
Autor:
S S, Negus, N K, Mello
Publikováno v:
Experimental and clinical psychopharmacology. 7(4)
This study examined the effects of the kappa opioid agonists U50,488 and ethylketocyclazocine (EKC) on cocaine discrimination in rhesus monkeys trained to discriminate cocaine (0.4 mg/kg) from saline. Administration of U50,488 and EKC alone produced
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(1)
The reinforcing effects of D(1-like) and D(2-like) agonists, and their capacity to modify cocaine self-administration, were compared in rats with extensive cocaine self-administration experience. Cocaine (0.01-1.0 mg i.v.) dose-dependently maintained