Zobrazeno 1 - 10 of 65 pro vyhledávání: '"S S, Mirvish"'
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Depentylation of the rat esophageal carcinogen, methyl-n-pentylnitrosamine, by microsomes from various human and rat tissues and by cytochrome P450 2A3
Autor: S C, Chen, L, Zhou, X, Ding, S S, Mirvish
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(9)
Methyl-n-pentylnitrosamine (MPN) is carcinogenic for the rat esophagus. To determine organ specificity for MPN activation by human tissues, microsomes isolated from human organs (snap-frozen6 h after death or removed surgically) were incubated with [
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cec1a11eda634ab6408fd04e06dd0406
https://pubmed.ncbi.nlm.nih.gov/11502732
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3
Depentylation of [3H-pentyl]methyl-n-amylnitrosamine by rat esophageal and liver microsomes and by rat and human cytochrome P450 isoforms
Autor: S C, Chen, X, Wang, G, Xu, L, Zhou, J L, Vennerstrom, F, Gonzalez, H V, Gelboin, S S, Mirvish
Publikováno v: Cancer research. 59(1)
Methyl-n-amylnitrosamine (MNAN) induces esophageal cancer in rats, probably involving activation by cytochromes P450. We studied the metabolic depentylation of MNAN. [3H-4,5-pentyl]MNAN and [3H-2,3-pentyl]-MNAN were synthesized, purified, and incubat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48adcfafb9ff32f22d0da5ddb391860f
https://pubmed.ncbi.nlm.nih.gov/9892192
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4
Studies on experimental animals involving surgical procedures and/or nitrosamine treatment related to the etiology of esophageal adenocarcinoma
Autor: S S, Mirvish
Publikováno v: Cancer letters. 117(2)
After a brief review of the epidemiology and etiology of lower esophageal adenocarcinoma (EAC), this paper describes long-term experiments on animals (mostly rats) demonstrating that reflux of duodenal contents into the stomach can induce gastric and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b33455ccad3a773ec288095da9ff091
https://pubmed.ncbi.nlm.nih.gov/9377544
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5
Dosing time with ascorbic acid and nitrate, gum and tobacco chewing, fasting, and other factors affecting N-nitrosoproline formation in healthy subjects taking proline with a standard meal
Autor: S S, Mirvish, A C, Grandjean, K J, Reimers, B J, Connelly, S C, Chen, J, Gallagher, S, Rosinsky, G, Nie, H, Tuatoo, S, Payne
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 4(7)
The N-nitrosoproline (NPRO) test measures the potential for intragastric formation of carcinogenic nitrosamines in humans. Nitrate and L-proline are administered to volunteers. Noncarcinogenic NPRO is produced by an acid-catalyzed reaction of proline
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b8ddcfdba5bd03d01a5d9aa21b7a2175
https://pubmed.ncbi.nlm.nih.gov/8672996
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6
Experimental evidence for inhibition of N-nitroso compound formation as a factor in the negative correlation between vitamin C consumption and the incidence of certain cancers
Autor: S S, Mirvish
Publikováno v: Cancer research. 54
Ascorbic acid (ASC) consumption is negatively correlated with the incidence of certain cancers. This is a review and update of the theory, which has recently been neglected, that this negative correlation is due to ASC inhibition of in vivo nitrosati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9468d60cac685fe76e146ae0bdc5a49
https://pubmed.ncbi.nlm.nih.gov/8137317
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8
N-nitrosoproline excretion by rural Nebraskans drinking water of varied nitrate content
Autor: S S, Mirvish, A C, Grandjean, H, Moller, S, Fike, T, Maynard, L, Jones, S, Rosinsky, G, Nie
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 1(6)
The N-nitrosoproline (NPRO) test for in vivo nitrosation was applied in a study of 44 rural Nebraska men drinking high- or low-nitrate water from private wells. The subjects followed diets low in NPRO and nitrate for 5 days. On days 4 and 5 they avoi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36f425a48c6147a124c2bd3ac79daf13
https://pubmed.ncbi.nlm.nih.gov/1302557
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9
Metabolism of N-nitrosomethyl-n-amylamine by microsomes from human and rat esophagus
Autor: Q, Huang, G, Stoner, J, Resau, J, Nickols, S S, Mirvish
Publikováno v: Cancer research. 52(13)
Asymmetric dialkylnitrosamines induce esophageal cancer in rats and hence might be involved in the etiology of this cancer in humans. As a test of this hypothesis, we examined whether nitrosamines can be activated by segments of human esophagus and b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24a1b5718d407edcd890bdc00166604b
https://pubmed.ncbi.nlm.nih.gov/1617624
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10
Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats
Autor: S E, Attwood, T C, Smyrk, T R, DeMeester, S S, Mirvish, H J, Stein, R A, Hinder
Publikováno v: Surgery. 111(5)
The carcinogenic effect of duodenoesophageal reflux, gastroesophageal reflux, and nitrosamines was studied in the rat esophagus.Twenty male Sprague-Dawley rats underwent esophagogastroplasty to produce gastroesophageal reflux and 60 underwent duodeno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8da5abb4e6669056db197348505e0413
https://pubmed.ncbi.nlm.nih.gov/1598670
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