Data from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression

Autor: D. Michiel Pegtel, Nicola Baldini, Tom Wurdinger, Sulev Köks, Katre Maasalu, Aare Martson, Vincenzo Canzonieri, Agostino Steffan, Silvia Cervo, Nicoletta Zini, Tanja D. de Gruijl, Sinead M. Lougheed, Roberta Bonafede, Massimo Dominici, Giulia Grisendi, Monique A.J. van Eijndhoven, Michelina Greco, Laura Roncuzzi, Ekaterina S. Jordanova, Anne-Marie Cleton-Jansen, Sonia A. Melo, Nicolas Léveillé, Xuan Dung Ho, Maria Pérez-Lanzón, Tonny Lagerweij, S. Rubina Baglio

Purpose: Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because druggable driver mutations have not been established, dissecting the interactions betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06e10495adba46e2af40f470d40a695
https://doi.org/10.1158/1078-0432.c.6526500.v1

Censoring exosomal crosstalk in osteoarthritis

Autor: Ingrid Meulenbelt, S. Rubina Baglio, D. Michiel Pegtel, Yolande F M Ramos

Publikováno v: Nature Aging, 1(4), 332-334. Springer
Meulenbelt, I, Ramos, Y F M, Baglio, S R & Pegtel, D M 2021, ' Censoring exosomal crosstalk in osteoarthritis ', Nature Aging, vol. 1, no. 4, pp. 332-334 . https://doi.org/10.1038/s43587-021-00052-4

Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to an increase in metalloproteinase activity in cartilage. A bone-specific inhibitor of exosome production can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c01df3aee2faed74bb4cce41e594135
https://research.vumc.nl/en/publications/466eac18-f77b-4515-8fd6-583ad44748ac

Packaging RNA drugs into extracellular vesicles

Autor: Monique A J, van Eijndhoven, S Rubina, Baglio, D Michiel, Pegtel

Publikováno v: Nature biomedical engineering. 4(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::397464a4a9f8709e83faa91ebbdc3f14
https://pubmed.ncbi.nlm.nih.gov/31937944

Biogenesis and function of extracellular vesicles in cancer

Autor: S. Rubina Baglio, Martine J. Smit, D. Michiel Pegtel, Maarten P. Bebelman

Publikováno v: Bebelman, M P, Smit, M J, Pegtel, D M & Baglio, S R 2018, ' Biogenesis and function of extracellular vesicles in cancer ', Pharmacology and Therapeutics, vol. 188, pp. 1-11 . https://doi.org/10.1016/j.pharmthera.2018.02.013
Bebelman, M P, Smit, M J, Pegtel, D M & Baglio, S R 2018, ' Biogenesis and function of extracellular vesicles in cancer ', Pharmacology and Therapeutics, vol. 188, pp. 1-11 . https://doi.org/10.1016/j.pharmthera.2018.02.013, https://doi.org/10.1016/j.pharmthera.2018.02.013
Pharmacology & Therapeutics

Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58c517abb5910b5fe9973dca28e9f00
https://hdl.handle.net/1871.1/2ae8e649-8282-4c7c-87fb-fbb0c1887584

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

Autor: Juan J. Garcia-Vallejo, D. Michiel Pegtel, Connie R. Jimenez, Martine J. Smit, Anoek Zomer, Frederik J. Verweij, Marc G. Coppolino, Graça Raposo, S. Rubina Baglio, Hans Janssen, Jaco C. Knol, Jacques Neefjes, Sander R. Piersma, Jacco van Rheenen, Maarten P. Bebelman, Matthijs Verhage, Guillaume van Niel, Jaap M. Middeldorp, Richard de Goeij-de Haas, Ruud F. Toonen, Ilse Hurbain

Publikováno v: Verweij, F J, Bebelman, M P, Jimenez, C R, Garcia-Vallejo, J J, Janssen, H, Neefjes, J, Knol, J C, de Goeij-de Haas, R, Piersma, S R, Baglio, S R, Verhage, M, Middeldorp, J M, Zomer, A, van Rheenen, J, Coppolino, M G, Hurbain, I, Raposo, G, Smit, M J, Toonen, R F G, van Niel, G & Pegtel, D M 2018, ' Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling ', Journal of Cell Biology, vol. 217, no. 3, pp. 1129-1142 . https://doi.org/10.1083/jcb.201703206
The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, 2018, 217 (3), pp.1129-1142. ⟨10.1083/jcb.201703206⟩
Journal of Cell Biology, 217(3), 1129-1142. Rockefeller University Press
Journal of Cell Biology, 217(3), 1129. Rockefeller University Press
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (3), pp.1129-1142. ⟨10.1083/jcb.201703206⟩
Journal of Cell Biology, 217(3), 1129-1142

All mammalian cells release small endosome-derived exosomes that function in intercellular communication, but the secretion process is poorly understood. Verweij et al. developed a live-imaging approach and demonstrate that external cues can trigger

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d807d4f291bc079a77bc789b319fde04
https://hdl.handle.net/1871.1/091ce542-44c8-4022-aad1-3b7087ddd5f1