Výsledky vyhledávání - "S Rigby-Singleton"

Ex Situ and In Situ Characterization of Vaccine Suspensions in Pre-Filled Syringes

Autor: S Rigby-Singleton, Lavinia M. Lewis, Parag Kolhe, Jianxin Guo, Jijun Wang, Andrew Parker, Anthony L. Young, David O. Bates, Hilbert Billones, Ekaterina Torres

Publikováno v: Journal of pharmaceutical sciences. 106(8)

Ex situ and in situ techniques were used to characterize the suspended phase over time for a vaccine drug product supplied in syringes. Micro-computed tomography was used to characterize the suspended sediment in situ in the syringe, while traditiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d042ddad58095634e6badce6562ecbb3
https://pubmed.ncbi.nlm.nih.gov/28465152

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Chemical and spatial analysis of protein loaded PLGA microspheres for drug delivery applications

Autor: Ali Rafati, Clive J. Roberts, Alexander G. Shard, Morgan R. Alexander, Martyn C. Davies, S Rigby-Singleton, Xinyong Chen, David J. Scurr, Paul T. Whiteside, Kevin M. Shakesheff, Asme Boussahel

Publikováno v: University of Bristol-PURE
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Polymer microspheres for controlled release of therapeutic protein from within an implantable scaffold were produced and analysed using complimentary techniques to probe the surface and bulk chemistry of the microspheres. Time of Flight – Secondary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c9754f51b356a4ab0eefdba9d251b7

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Determination of the Influence of Primary Drying Rates on the Microscale Structural Attributes and Physicochemical Properties of Protein Containing Lyophilized Products

Autor: Robert E. Johnson, Claire E. Madden-Smith, Delphine Le Roux, Saleem S. Ahmed, Dirk L. Teagarden, David O. Bates, S Rigby-Singleton, Lavinia M. Lewis, Mark Perkins, Andrew Parker, Clive J. Roberts

Publikováno v: Journal of Pharmaceutical Sciences. 99:4616-4629

This work investigated the impact of primary drying conditions on the microstructure and protein stability of bovine serum albumin (BSA) containing lyophilized cakes. Two primary drying conditions were employed (termed ‘conservative’, slower dryi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44847603323c4da92256d1e090c262c7
https://doi.org/10.1002/jps.22185

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Towards the understanding and prediction of material changes during micronisation using atomic force microscopy

Autor: Nikin Patel, S Rigby-Singleton, Claire E. Madden-Smith, Jeff James, J. Ledru, Shen Y. Luk, Clive J. Roberts, Mark Perkins, Matt Bunker

Publikováno v: European Journal of Pharmaceutical Sciences. 38:1-8

In this study we aim to explore the potential links between the mechanical properties, micronisation behaviour and surface energy of carbamazepine polymorphs using atomic force microscopy (AFM) measurements of material properties at the nanoscale. Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca7fda3bfa874dd0f95041fc9ea41fe
https://doi.org/10.1016/j.ejps.2009.05.004

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Visualizing the Solubilization of Supported Lipid Bilayers by an Amphiphilic Peptide

Autor: Paul O'Shea, Stephanie Allen, Helen J. Harris, Martyn C. Davies, S Rigby-Singleton

Publikováno v: Langmuir. 22:6273-6279

The effect of the presequence peptide of cytochrome c oxidase subunit IV (p25) on supported phospholipid bilayers (SPBs) was visualized using atomic force microscopy (AFM). The presequence was found to cause the complete disruption of supported bilay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48781012ee1618612b49a2352053dc6a
https://doi.org/10.1021/la060114+

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Direct measurement of drug–enzyme interactions by atomic force microscopy; dihydrofolate reductase and methotrexate

Autor: Stephanie Allen, Martyn C. Davies, S Rigby-Singleton, Philip M. Williams, Clive J. Roberts, Saul J. B. Tendler

Publikováno v: J. Chem. Soc., Perkin Trans. 2. :1722-1727

There is a wealth of structural information on the drug–enzyme complex, dihydrofolate reductase and methotrexate. However, the dissociation dynamics of the complex remain relatively poorly understood. This paper describes the application of the ato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78775f7a8cffcb4e521d7489f889aace
https://doi.org/10.1039/b204290h

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Measuring and visualizing single molecular interactions in biology

Autor: Martyn C. Davies, H.J. Harris, Paul O'Shea, Stephanie Allen, S Rigby-Singleton

Publikováno v: Scopus-Elsevier

In recent years, considerable attention has focused upon the biological applications of the atomic force microscope (AFM), and in particular in its ability to explore biomolecular interaction events at the single molecule level. Such measurements can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a5d760d7f1eece6dbba8f54711e8fa
http://www.scopus.com/inward/record.url?eid=2-s2.0-0142153332&partnerID=MN8TOARS

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Akademický článek

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Akademický článek

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