Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it

Autor: L.W. Wormhoudt, Q.J Li, S Ramnatshing, Nico P. E. Vermeulen, E.J. Groot, J. P. G. Brakenhoff, Jan N. M. Commandeur

Publikováno v: Chemico-Biological Interactions, 110, 139-158. Elsevier Ireland Ltd
Vrije Universiteit Amsterdam
Chemico-Biological Interactions, 110(3), 139-58. Elsevier Ireland Ltd
Vermeulen, N P, Commandeur, J N, Groot, E J, Wormhoudt, L W, Ramnatshing, S, Li, Q J & Brakenhoff, J P 1998, ' Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it ', Chemico-Biological Interactions, vol. 110, no. 3, pp. 139-58 . https://doi.org/10.1016/S0009-2797(98)00004-0
Vermeulen, N P E, Commandeur, J N M, Groot, E J, Wormhoudt, L W, Ramnathsing, S, Li, Q J & Brakenhoff, J P G 1998, ' Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it. ', Chemico-Biological Interactions, vol. 110, pp. 139-158 . https://doi.org/10.1016/S0009-2797(98)00004-0

Fotemustine is a relatively novel DNA-alkylating 2-chloroethyl-substituted N-nitrosourea (CENU) drug, clinically used for the treatment of disseminated malignant melanoma in different visceral and non-visceral tissues. Thrombocytopenia has been obser

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https://research.vu.nl/en/publications/03fbe49f-c862-40d1-848a-e14fa9c13e8a