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Rapid quantitative determination of a collagenase inhibitor and its major metabolite by on-line liquid chromatography with ionspray tandem mass spectrometric detection

Autor: M. J. Madigan, S. R. Sharp, N. G. Knebel

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 673:213-222

A rapid, sensitive and specific analytical method has been developed and validated to quantify the collagenase inhibitor N2-(2(5)-[(hydroxycarbamoyl)methyl)-4-methylvaleryl]-N1, 3-dimethyl-L-valin-amide (I) and its major metabolite (II) from plasma a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e687b4a54ae1d586c04a632f64272f
https://doi.org/10.1016/0378-4347(95)00270-2

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Quantification of the anti-HIV drug saquinavir by high-speed on-line high-performance liquid chromatography/tandem mass spectrometry

Autor: S. R. Sharp, N. G. Knebel, M. J. Madigan

Publikováno v: Journal of Mass Spectrometry. 30:1149-1156

A method is described for the fast routine determination of the anti-HIV drug saquinavir and its pentadeuterated analogue [2H5] saquinavir in the plasma of healthy volunteers. The method is based on high-performance liquid chromatography (HPLC)/atmos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b54ca471d76e674260f265e96ab2f3db
https://doi.org/10.1002/jms.1190300812

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Metabolism of the calcium antagonist, mibefradil (POSICOR, Ro 40-5967). Part II. Metabolism in hepatic microsomes from rat, marmoset, cynomolgus monkey, rabbit and man

Autor: M J Madigan, G Heeps, Hugh R. Wiltshire, A M Betty, B M Sutton, S R Sharp, D W Angus

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 27(6)

1. The calcium antagonist, mibefradil, is converted to some 30 metabolites after incubation with hepatic microsomes from the rat, marmoset, cynomolgus monkey, rabbit and man. 2. The wide inter-species differences in metabolic profile stem mainly from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14577542c6289917c9595c225ea5190f
https://pubmed.ncbi.nlm.nih.gov/9211655

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P130 Antibiotic resistance profiles ofNeisseria gonorrhoeae(GC): a comparison of data 2007–2011: Abstract P130 Table1

Autor: Sris Allan, S R Sharp

Publikováno v: Sexually Transmitted Infections. 88:A53.1-A53

Objectives This was a retrospective analysis of antibiotic use and resistance profiles of GC at a UK GU clinic. Methods All GC cases at our clinic between 1 January to 1 June in 2007, 2009, and 2011 were identified. The case notes were assessed for a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::963642015ba952dd42035273810c7f6f
https://doi.org/10.1136/sextrans-2012-050601c.130

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P129 Improving clinical standards in GU medicine: a retrospective audit ofNeisseria gonorrhoeae

Autor: S R Sharp, Sris Allan

Publikováno v: Sexually Transmitted Infections. 88:A52.3-A53

Objectives This was a retrospective analysis of clinic performance in the management and treatment of Neisseria gonorrhoeae (GC) according to BASHH guidelines. Methods All cases of GC diagnosed at our clinic between 1 January and 30 June 2011 were id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d71e90f237a31f3db76c99107a46061
https://doi.org/10.1136/sextrans-2012-050601c.129

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