Zobrazeno 1 - 9 of 9 pro vyhledávání: '"S R Murthy Madiraju"'
1
Akademický článek
Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression.
Autor: Émilie Pepin, Anfal Al-Mass, Camille Attané, Kezhuo Zhang, Julien Lamontagne, Roxane Lussier, S R Murthy Madiraju, Erik Joly, Neil B Ruderman, Robert Sladek, Marc Prentki, Marie-Line Peyot
Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0153017 (2016)
Diet induced obese (DIO) mice can be stratified according to their weight gain in response to high fat diet as low responders (LDR) and high responders (HDR). This allows the study of β-cell failure and the transitions to prediabetes (LDR) and early
Externí odkaz: https://doaj.org/article/a816a82e402c4a1b82063292ec35e8b2
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2
Akademický článek
Differential Insulin Secretion of High-Fat Diet-Fed C57BL/6NN and C57BL/6NJ Mice: Implications of Mixed Genetic Background in Metabolic Studies.
Autor: Camille Attané, Marie-Line Peyot, Roxane Lussier, Dongwei Zhang, Erik Joly, S R Murthy Madiraju, Marc Prentki
Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159165 (2016)
Many metabolic studies employ tissue-specific gene knockout mice, which requires breeding of floxed gene mice, available mostly on C57BL/6N (NN) genetic background, with cre or Flp recombinase-expressing mice, available on C57BL/6J (JJ) background, r
Externí odkaz: https://doaj.org/article/20f8b6bde0fb4134a26ff3d93c8a4c6e
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3
Akademický článek
A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.
Autor: Claudiane Guay, Erik Joly, Emilie Pepin, Annie Barbeau, Lisa Hentsch, Marco Pineda, S R Murthy Madiraju, Henri Brunengraber, Marc Prentki
Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77097 (2013)
Cytosolic NADPH may act as one of the signals that couple glucose metabolism to insulin secretion in the pancreatic ß-cell. NADPH levels in the cytoplasm are largely controlled by the cytosolic isoforms of malic enzyme and isocitrate dehydrogenase (
Externí odkaz: https://doaj.org/article/fc9c21b5e2474577b5507612818a8807
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4
Akademický článek
Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells.
Autor: Marie-Line Peyot, Joshua P Gray, Julien Lamontagne, Peter J S Smith, George G Holz, S R Murthy Madiraju, Marc Prentki, Emma Heart
Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6221 (2009)
BACKGROUND:Glucagon like peptide-1 (GLP-1) and its analogue exendin-4 (Ex-4) enhance glucose stimulated insulin secretion (GSIS) and activate various signaling pathways in pancreatic beta-cells, in particular cAMP, Ca(2+) and protein kinase-B (PKB/Ak
Externí odkaz: https://doaj.org/article/7d396a0b850a4ad5aa357832404999c2
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5
Akademický článek
New Mammalian Glycerol-3-Phosphate Phosphatase: Role in β-Cell, Liver and Adipocyte Metabolism
Autor: Elite Possik, Anfal Al-Mass, Marie-Line Peyot, Rasheed Ahmad, Fahd Al-Mulla, S. R. Murthy Madiraju, Marc Prentki
Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)
Cardiometabolic diseases, including type 2 diabetes, obesity and non-alcoholic fatty liver disease, have enormous impact on modern societies worldwide. Excess nutritional burden and nutri-stress together with sedentary lifestyles lead to these diseas
Externí odkaz: https://doaj.org/article/3976edef258f41cfaceb22b4353f8d6e
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7
Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
Autor: Elite Possik, Clémence Schmitt, Anfal Al-Mass, Ying Bai, Laurence Côté, Johanne Morin, Heidi Erb, Abel Oppong, Wahab Kahloan, J. Alex Parker, S. R. Murthy Madiraju, Marc Prentki
Publikováno v: Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d25c780969f77baa4838948f5073fd2
https://pubmed.ncbi.nlm.nih.gov/35017476
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8
Short-chain 3-hydroxyacyl-CoA dehydrogenase is a negative regulator of insulin secretion in response to fuel and non-fuel stimuli in INS832/13 β-cells
Autor: Emilie, Pepin, Claudiane, Guay, Viviane, Delghingaro-Augusto, Erik, Joly, S R Murthy, Madiraju, Marc, Prentki
Publikováno v: Journal of diabetes. 2(3)
Hyperinsulinemia associated with non-ketotic hypoglycemia is observed in patients with mutated β-oxidation enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase (HADHSC). In the present study, we investigated the mechanism underlying HADHSC-mediated re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ee03a68ecfae3e09396adb9f9aee185
https://pubmed.ncbi.nlm.nih.gov/20923481
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9
Akademický článek
Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
Autor: Elite Possik, Clémence Schmitt, Anfal Al-Mass, Ying Bai, Laurence Côté, Johanne Morin, Heidi Erb, Abel Oppong, Wahab Kahloan, J. Alex Parker, S. R. Murthy Madiraju, Marc Prentki
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Glycerol-3-phosphate phosphatase is a recently discovered enzyme at the heart of metabolism. Here, the authors used C. elegans and showed that its activation promotes stress resistance, healthy aging and acts as a calorie restriction mimetic at norma
Externí odkaz: https://doaj.org/article/7ec50e33ccdf4e78a7f7c66bddf1bd95
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