Zobrazeno 1 - 10
of 20
pro vyhledávání: '"S R Lessin"'
Publikováno v:
The Journal of Immunology. 156:1402-1407
IL-12 is a 70-kDa heterodimeric cytokine composed of a p35 chain and p40 chain. This cytokine exerts a powerful positive regulatory influence on the development of Th1 helper T-cell immune responses and is a potent inducer of IFN-gamma production and
Autor:
S Nussen-Lee, Barbara L. Weber, Anne-Marie Martin, Robin H. Edwards, S R Lessin, Meenhard Herlyn, Marcia S. Brose, Michelle Renee Ward, H M Haupt, C A Medina, H Wu, Patricia Volpe
Publikováno v:
Journal of Medical Genetics. 41:270-272
Background: Mutations in BRAF have recently been identified in a significant percentage of primary and metastatic cutaneous malignant melanomas. As ultraviolet (UV) exposure may play a role in the development of cutaneous melanoma lesions with BRAF m
Autor:
A H Rook, M Kubin, M Cassin, E C Vonderheid, B R Vowels, J T Wolfe, S F Wolf, A Singh, G Trinchieri, S R Lessin
Publikováno v:
The Journal of Immunology. 154:1491-1498
Cutaneous T cell lymphoma is a lymphoproliferative disorder typically characterized by skin invasion of clonally derived malignant CD4+ lymphocytes that phenotypically resemble mature Th cells. Sezary syndrome (SzS) represents an advanced form of cut
Publikováno v:
The Journal of Immunology. 152:4062-4069
This study establishes the primary structure of human skin chymase and provides further evidence for the presence of a cathepsin G-like proteinase within human mast cells. The amino acid sequence of human skin chymase was established by protein metho
Publikováno v:
The Journal of Immunology. 146:1455-1462
The establishment of an in vitro model for cutaneous T cell lymphomas and Sézary syndrome has been difficult since T cells from individuals with these diseases do not proliferate in response to T cell mitogens. We found that conditioned media, colle
Autor:
J K, Wildemore, L, Schuchter, R, Mick, M, Synnestvedt, R, Elenitsas, I, Bedrosian, B J, Czerniecki, D, Guerry, S R, Lessin, D E, Elder, L P, Bucky
Publikováno v:
Annals of plastic surgery. 46(5)
Despite improvements in the identification and treatment of melanoma, local recurrence continues to challenge the success of current melanoma therapy. A retrospective analysis of 1,996 patients presenting from 1990 to 1997 at the Pigmented Lesion Gro
Autor:
A H, Rook, G S, Wood, E K, Yoo, R, Elenitsas, D M, Kao, M L, Sherman, W K, Witmer, K A, Rockwell, R B, Shane, S R, Lessin, E C, Vonderheid
Publikováno v:
Blood. 94(3)
Progression of cutaneous T-cell lymphoma (CTCL) is associated with profound defects in cell-mediated immunity and depressed production of cytokines, which support cell-mediated immunity. Because we have observed marked defects in interleukin-12 (IL-1
Publikováno v:
Clinical and experimental immunology. 107
Cutaneous T-cell lymphoma (CTCL) is a clonally derived, skin invasive malignancy of CD4+ cells with the phenotype of mature helper T cells. We previously demonstrated that the leukaemic form of CTCL (Sézary), is characterized by prominent immunologi
Publikováno v:
Archives of dermatology. 132(1)
The serum concentration of soluble alpha-chain receptor for interleukin-2 (sIL-2R) was determined in 101 patients with cutaneous T-cell lymphoma (CTCL).The serum concentration of sIL-2R correlates positively with CTCL tumor burden as determined by se
Publikováno v:
Blood. 86(11)
To determine if circulating Sezary cells can be classified as reactive or neoplastic based on the ability to detect the presence or absence of clonal T-cell receptor beta chain (TCR-beta) gene rearrangements by Southern blot analysis, we evaluated th