Zobrazeno 1 - 10
of 20
pro vyhledávání: '"S R G Beckett"'
Autor:
Maulik D. Jhaveri, David A. Kendall, Charles A. Marsden, A. Madjd, S. R. G. Beckett, David P. Finn, Victoria Chapman
Publikováno v:
Neuroscience. 138:1309-1317
Fear-conditioned analgesia is an important survival response which is expressed upon re-exposure to a context previously paired with a noxious stimulus. The aim of the present study was to characterize further the behavioral, monoaminergic and hypoth
Autor:
S. R. G. Beckett, Alison J. Ford, Sharon C Stratton, Clare Roe, Russell Michael Hagan, Eric Southam, Jane D. Wheable, Rebecca S Sargent, Rui Pereira, Lindsay J. Butterfield, Charles A. Marsden
Publikováno v:
European Journal of Pharmacology. 519:237-245
Recent clinical evidence indicates that the broad spectrum anticonvulsant drug lamotrigine is effective against the depressive phase of bipolar illness and the difficult to treat rapid cycling form of the disorder. However, the molecular mechanism un
Publikováno v:
Psychopharmacology. 177:23-34
The social interaction test is a valuable behavioural model for testing anxiolytic drugs in rodents, quantifying the level of social behaviour between pairs of rats.The aim of the present study was to assess the appropriateness of the social interact
Autor:
Victoria Chapman, David P. Finn, S. R. G. Beckett, Charles A. Marsden, David A. Kendall, Maulik D. Jhaveri
Publikováno v:
Psychopharmacology. 172:41-51
Mechanisms and brain substrates mediating cannabinoid-induced modulation of behaviour towards aversive stimuli are poorly understood.To investigate the effects of systemic and intra-dorsal periaqueductal grey (PAG) administration of the cannabinoid r
Publikováno v:
British Journal of Pharmacology. 141:253-262
1. The ability of the endogenous fatty acid amide, cis-oleamide (ODA), to bind to and activate cannabinoid CB(1) and CB(2) receptors was investigated. 2. ODA competitively inhibited binding of the nonselective cannabinoid agonist [(3)H]CP55,940 and t
Autor:
S. R. G. Beckett, Randall L. Commissaris, Margaret Graham, Charles A. Marsden, Alan R. Palmer, Savvas Ioannou Neophytou
Publikováno v:
Physiology & Behavior. 68:521-531
It has been reported previously that experimenter-presented 20-kHz tones at low intensities produce bursts of locomotor running in Lister hooded rats, but reduced locomotion (freezing) in Wistar rats. Because rats emit 20-kHz tones when stressed, it
Publikováno v:
Brain Research Bulletin. 42:421-426
Exposure of rats to aversive stimuli produces specific defence behaviour including the emission of 20-27kHz ultrasonic calls. Recent studies in this laboratory have shown that rats exposed to a 20kHz ultrasound tone display flight behaviour similar t
Autor:
Charles A. Marsden, S. R. G. Beckett
Publikováno v:
Journal of Psychopharmacology. 11:35-40
The effects of the selective 5-HT1A agonist, 8-hydroxy-2-(di- n-propylamino)-tetralin (8-OHDPAT) and the selective 5-HT1A antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperzinyl]ethyl]-N-(pyridinyl) cyclohexanecarboxa mide trichloride (WAY100635) on peria
Publikováno v:
Behavioural brain research. 202(2)
Deficits in pre-pulse inhibition (PPI-indicative of psychosis in humans) can be replicated in rats using the NMDA receptor antagonist phencyclidine (PCP). Ultrasonic vocalisations (USVs) produced by rats in response to acoustic startle are indicative
Autor:
Clare H. Spicer, Xavier Langlois, S. R. G. Beckett, Geoffrey W. Bennett, David Ashton, Christine Norman
Publikováno v:
Journal of psychopharmacology (Oxford, England). 22(3)
Neurotensin (NT) has been proposed as an endogenous antipsychotic based in part on the similarity in behavioural effects to antipsychotic drugs, for example, attenuation of both amphetamine-induced hyperlocomotion (AH) and amphetamine disrupted pre-p