Výsledky vyhledávání - "S R Coughlin"

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor

Autor: Brian K. Kobilka, Lutz Hein, K Ishii, S R Coughlin

Publikováno v: Journal of Biological Chemistry. 269:27719-27726

The receptor for the protease thrombin is a member of the G protein-coupled receptor family, but is activated by a unique proteolytic mechanism. The irreversibility of this proteolytic mechanism and the fact that the ligand is tethered to its recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::517cb1f5f63c6563b4901fead5c01561
https://doi.org/10.1016/s0021-9258(18)47045-7

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The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity

Autor: Charles T. Esmon, L W Liu, S R Coughlin, Thien Khai H Vu

Publikováno v: Journal of Biological Chemistry. 266:16977-16980

A thrombin receptor has recently been cloned and the sequence deduced. The sequence reveals a thrombin cleavage site that accounts for receptor activation. The receptor also has an acidic region with some similarities to the carboxyl-terminal region

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6782ee59d407ec330653dc8a7b5233f4
https://doi.org/10.1016/s0021-9258(19)47326-2

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Protease-activated receptors in vascular biology

Autor: S R, Coughlin

Publikováno v: Thrombosis and haemostasis. 86(1)

G protein-coupled protease-activated receptors (PARs) provide one answer to the question of how coagulation factors and other proteases regulate cellular behaviors. In concert with the coagulation cascade, these receptors provide an elegant mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c4fb8ef2aac7a2cf92ddd5bacce1433
https://pubmed.ncbi.nlm.nih.gov/11487018

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Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits

Autor: J, Trejo, Y, Altschuler, H W, Fu, K E, Mostov, S R, Coughlin

Publikováno v: The Journal of biological chemistry. 275(40)

Protease-activated receptor-1 (PAR1), a G protein-coupled receptor (GPCR) for thrombin, is irreversibly activated by a proteolytic mechanism, then internalized and degraded in lysosomes. The latter is critical for temporal fidelity of thrombin signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f93d551b50c82008d283572ecf9150bc
https://pubmed.ncbi.nlm.nih.gov/10893235

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Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function

Autor: T R, Faruqi, E J, Weiss, M J, Shapiro, W, Huang, S R, Coughlin

Publikováno v: The Journal of biological chemistry. 275(26)

Thrombin activates protease-activated receptors (PARs) by specific cleavage of their amino-terminal exodomains to unmask a tethered ligand that binds intramolecularly to the body of the receptor to effect transmembrane signaling. Peptides that mimic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1114ae34682f71d2ca27dec73c41ed01
https://pubmed.ncbi.nlm.nih.gov/10779527

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Protease-activated receptors and platelet function

Autor: S R, Coughlin

Publikováno v: Thrombosis and haemostasis. 82(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::277dd2886f40c4410479a2b46c1f6eb1
https://pubmed.ncbi.nlm.nih.gov/10605724

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Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype

Autor: M L, Kahn, T G, Diacovo, D F, Bainton, F, Lanza, J, Trejo, S R, Coughlin

Publikováno v: Blood. 94(12)

Adhesion of platelets to extracellular matrix via von Willebrand factor (vWF) and activation of platelets by thrombin are critical steps in hemostasis. Glycoprotein (GP) V is a component of the GPIb-V-IX complex, the platelet receptor for vWF. GPV is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3ae63a62e94fd8c2f88ec6847de6c41
https://pubmed.ncbi.nlm.nih.gov/10590056

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The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration

Autor: G R, Sambrano, S R, Coughlin

Publikováno v: The Journal of biological chemistry. 274(29)

The G protein-coupled thrombin receptor, protease-activated receptor 1 (PAR1), mediates many of the actions of thrombin on cells including chemotaxis. In contrast to the reversible agonist binding that regulates signaling by most G protein-coupled re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b8329c1ebedeb8b4e18c64c96ac2e273
https://pubmed.ncbi.nlm.nih.gov/10400633

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Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids

Autor: S, An, T, Bleu, W, Huang, O G, Hallmark, S R, Coughlin, E J, Goetzl

Publikováno v: FEBS letters. 417(3)

The structural similarity of lysosphingolipids to lysophosphatidic acid (LPA) prompted a sequence-based search for lysosphingolipid receptors using cDNA sequence of the Edg2 human LPA receptor. Two closely related G protein-coupled receptors, rat H21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c85fb5469b4266aae3fcbc091817662
https://pubmed.ncbi.nlm.nih.gov/9409733

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