Zobrazeno 1 - 10
of 16
pro vyhledávání: '"S R, Winn"'
Autor:
Denise Lafreniere, Dwaine F. Emerich, S. R. Winn, Tania Wiens, Mary Agostino, Raymond T. Bartus, Hua Xiong, Pamela Snodgrass
Publikováno v:
Pharmaceutical Research. 17:776-781
Purpose. Delivery of chemotherapeutics using implantable,biodegradable polymers provides a potentially powerful method of treating braintumors. The present studies examined the ability of injectablemicrospheres, formulated to release carboplatin or B
Autor:
Tania Wiens, Denise Lafreniere, Raymond T. Bartus, S. R. Winn, Yunhua Hu, Brant P. Hasler, Pamela Snodgrass, Joanne Marsh, Dwaine F. Emerich
Publikováno v:
Pharmaceutical Research. 17:767-775
Purpose. Implantation of biodegradable polymers provides a powerfulmethod to deliver high, sustained concentrations of chemotherapeuticsto brain tumors. The present studies examined the ability of injectablepolymeric microspheres, formulated to relea
Autor:
C K, Enestvedt, L, Hosack, T, Hoppo, K A, Perry, R W, O'Rourke, S R, Winn, J G, Hunter, B A, Jobe
Publikováno v:
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 25(5)
Proper anastomotic healing is dependent upon many factors including adequate blood flow to healing tissue. The aim of this study was to investigate the impact of vascular endothelial growth factor (VEGF(165)) transfection on anastomotic healing in an
Publikováno v:
ASAIO Journal. 38:17-23
Parkinson's disease, a neurologic disorder characterized by a dopamine deficit within the striatum, may be improved by transplantation of polymer encapsulated neurosecretory cells. Surrounding cells with a selectively permeable barrier offers several
Autor:
D F, Emerich, S R, Winn
Publikováno v:
Critical reviews in therapeutic drug carrier systems. 18(3)
Delivery of potentially therapeutic drugs to the brain is hindered by the blood-brain barrier (BBB), which restricts the diffusion of drugs from the vasculature to the brain parenchyma. One means of overcoming the BBB is with cellular implants that p
Autor:
D F, Emerich, S R, Winn, P, Snodgrass, D, LaFreniere, M, Agostino, T, Wiens, H, Xiong, R T, Bartus
Publikováno v:
Pharmaceutical research. 17(7)
Delivery of chemotherapeutics using implantable, biodegradable polymers provides a potentially powerful method of treating brain tumors. The present studies examined the ability of injectable microspheres, formulated to release carboplatin or BCNU fo
Autor:
D F, Emerich, S R, Winn, Y, Hu, J, Marsh, P, Snodgrass, D, LaFreniere, T, Wiens, B P, Hasler, R T, Bartus
Publikováno v:
Pharmaceutical research. 17(7)
Implantation of biodegradable polymers provides a powerful method to deliver high, sustained concentrations of chemotherapeutics to brain tumors. The present studies examined the ability of injectable polymeric microspheres, formulated to release car
Publikováno v:
Journal of biomedical materials research. 45(4)
A tissue-engineered bone biomimetic device was developed to regenerate calvaria critical-sized defects (CSDs) in athymic rats. Well-documented evidence clearly confirms that left untreated, CSDs will not spontaneously regenerate bone. To accomplish r
Publikováno v:
Brain research. 736(1-2)
The present study examined the effects of encapsulated cells which were genetically modified to secrete human glail-derived neurotrophic factor (hGDNF) on the motor deficits in aged rodents. Prior to implantation, animals were tested on a battery of
Publikováno v:
Biotechnology and bioengineering. 50(4)
The present studies were undertaken to evaluate the in vitro gel stability of the hydrogels alginate and agarose. Gel strength (of alginate and agarose) and protein diffusion (of alginate only) were shown to correlate with gel stability and to be use