Zobrazeno 1 - 10
of 11
pro vyhledávání: '"S R, Saklad"'
Autor:
S A, Thornberg, S R, Saklad
Publikováno v:
Pharmacotherapy. 16(1)
Current models of drug-induced psychosis insufficiently describe the symptoms of schizophrenia. Phencyclidine-induced psychosis is a model that more completely reflects the pathophysiology of the disease. By decreasing glutamatergic neurotransmission
Autor:
S R, Saklad
Publikováno v:
Pharmacotherapy. 15(6 Pt 2)
The advent of newer, more expensive antidepressant agents in the past decade has focused renewed attention on major depressive disorder. The higher costs associated with purchasing the drugs makes their use appear to increase the cost of treating dep
Publikováno v:
Journal of clinical psychopharmacology. 11(5)
Fifty-nine plasma thiothixene concentrations were measured in 42 patients as part of routine therapeutic drug monitoring. Data collection included concomitant medications, smoking history, and demographic variables. A retrospective analysis was perfo
Autor:
W H, Chang, M W, Jann, H G, Hwu, T Y, Chen, S K, Lin, J M, Wang, L, Ereshefsky, S R, Saklad, A L, Richards, Y W, Lam
Publikováno v:
Journal of the Formosan Medical Association = Taiwan yi zhi. 90(6)
Steady-state haloperidol (HAL) and reduced HAL (RHAL) plasma levels were measured in Chinese and non-Chinese schizophrenic patients. The patients (n = 38) were matched according to age (+/- 1 yr) and by HAL dose. In general, Chinese patients had high
Autor:
M G, Choc, F, Hsuan, G, Honigfeld, W T, Robinson, L, Ereshefsky, M L, Crismon, S R, Saklad, J, Hirschowitz, R, Wagner
Publikováno v:
Pharmaceutical research. 7(4)
Clozapine plasma levels were monitored in 16 patients during a series of three consecutive treatments (single dose-multiple dose-single dose). Each patient received a single 75-mg dose (3 x 25 mg) with clozapine tablets, and serial plasma samples wer
Publikováno v:
Psychopharmacology bulletin. 26(1)
We have evaluated the efficacy and safety of different dosing regimens of haloperidol decanoate (HLD). Eighteen patients were evaluated as part of our ongoing Therapeutic Drug Monitoring Program. Diagnoses were chronic schizophrenia (n = 12), bipolar
Autor:
S R, Saklad
Publikováno v:
Clinical pharmacy. 6(3)
Publikováno v:
The Journal of clinical psychiatry. 45(5 Pt 2)
The future of depot neuroleptic therapy is discussed in terms of pharmacokinetic and pharmacodynamic research opportunities. Analytic methods for neuroleptic assays, including chromatographic, radioreceptor, nuclear magnetic resonance, and radioimmun
Publikováno v:
The Journal of clinical psychiatry.
The evolution of the federal government's role in the regulation and evaluation of generic psychotropic medications is described. To place many of the methodologic bioequivalence issues for antipsychotic agents into perspective, the pharmacokinetics
Autor:
L, Ereshefsky, C M, Davis, C A, Harrington, M W, Jann, J L, Browning, S R, Saklad, N R, Burch
Publikováno v:
Journal of clinical psychopharmacology. 4(3)
The first measurements of haloperidol (HL) and its reduced metabolite hydroxyhaloperidol (RH) in plasma versus clinical response in five chronic schizophrenic patients are reported. HL and RH were measured by a radioimmunoassay with a low coefficient