Zobrazeno 1 - 6
of 6
pro vyhledávání: '"S R, Nicholls"'
Publikováno v:
Antiviral Chemistry and Chemotherapy. 5:162-168
Novel haloalkyl phosphate derivatives of the anti-HIV nucleoside analogue AZT were prepared by phosphorochloridate chemistry. These materials were designed to act as labile membrane-soluble prodrugs of the bio-active free nucleotides. In vitro evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5127fde0452f92106272e830caa45664
https://doi.org/10.1177/095632029400500304
https://doi.org/10.1177/095632029400500304
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1207-1210
The 5′-bis(trichloroethyl) phosphate derivatives of several 3′-O-acyl thymidines were prepared from the thymidine phosphate. Even though the parent nucleosides are inactive as antiviral agents, the phosphates are selective inhibitors of the proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd32da7f3d694023d3c3c4beeadfe155
https://doi.org/10.1016/s0960-894x(00)80316-9
https://doi.org/10.1016/s0960-894x(00)80316-9
Publikováno v:
Antiviral Chemistry and Chemotherapy. 1:355-360
The reaction of thymidine, AZT (Fig. 1, compound 1) and ddCyd (Fig. 1, compound 2) with bis(2,2,2-trichloroethyl) phosphorochloridate gave novel 5′-bis(2,2,2-trichloroethyl) phosphates, characterized by spectroscopic and analytical data. Analogous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc1513fe364ec9ebdd539cd8f912438d
https://doi.org/10.1177/095632029000100603
https://doi.org/10.1177/095632029000100603
Publikováno v:
Antiviral Chemistry and Chemotherapy. 1:25-33
The reaction of thymidine with diethyl, dipropyl, and dibutyl phosphorochloridates yields novel 5′-(dialkyl phosphates), characterized by spectroscopic and analytical data. These are readily mesylated at the 3′-position. Similar reaction of 3′-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa95598d5a879a0feafebbce45f9c8d1
https://doi.org/10.1177/095632029000100105
https://doi.org/10.1177/095632029000100105
Publikováno v:
AIDS (London, England). 4(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86d98be61227e5c7d4e9f024e7b0fd34
https://pubmed.ncbi.nlm.nih.gov/2350460
https://pubmed.ncbi.nlm.nih.gov/2350460
Autor:
D. Kinchington, Caleb Nickson, S. R. Nicholls, Christopher McGuigan, M.F. Wang, S. Galpin, T. J. O'Connor, D.J. Jeffries
Publikováno v:
Antiviral Research. 20:55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca3c2c6b57fc067e4bb26d80979917f
https://doi.org/10.1016/0166-3542(93)90406-9
https://doi.org/10.1016/0166-3542(93)90406-9