Zobrazeno 1 - 6
of 6
pro vyhledávání: '"S R, Letchworth"'
Publikováno v:
The Journal of comparative neurology. 423(2)
The endogenous ligand for the orphan opioid receptor, orphanin FQ/nociceptin (OFQ), has recently been characterized. The OFQ peptide sequence contains paired basic amino acids, suggesting the possibility of posttranslational processing to a peptide c
Autor:
S R, Letchworth, H R, Smith, L J, Porrino, B A, Bennett, H M, Davies, T, Sexton, S R, Childers
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(2)
PTT (2beta-propanoyl-3beta-[4-tolyl] tropane) is a tropane analog relatively selective for dopamine transporters in binding and uptake assays in vitro, with long-acting psychostimulant properties in vivo. To explore its utility in binding to dopamine
Autor:
S R, Letchworth, T, Sexton, S R, Childers, K E, Vrana, R A, Vaughan, H M, Davies, L J, Porrino
Publikováno v:
Journal of neurochemistry. 73(5)
This study describes a direct comparison of dopamine transporter (DAT) mRNA and protein, as well as its binding sites, in tissue from the same animals after chronic cocaine administration. Rats were treated twice daily with 25 mg/kg cocaine or with s
Publikováno v:
Synapse (New York, N.Y.). 34(3)
The presence of pairs of basic amino acids within the orphanin FQ/Nociceptin (OFQ/N) sequence has raised the possibility that truncated versions of the peptide might be physiologically important. OFQ/N(1-11) is pharmacologically active in mice, despi
Autor:
I E, Goldberg, G C, Rossi, S R, Letchworth, J P, Mathis, J, Ryan-Moro, L, Leventhal, W, Su, D, Emmel, E A, Bolan, G W, Pasternak
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(2)
The recently isolated peptides endomorphin-1 and endomorphin-2 have been suggested to be the endogenous ligands for the mu receptor. In traditional opioid receptor binding assays in mouse brain homogenates, both endomorphin-1 and endomorphin-2 compet
Autor:
J B, Daunais, S L, Hart, H R, Smith, S R, Letchworth, H M, Davies, T, Sexton, B A, Bennett, S R, Childers, L J, Porrino
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(3)
2beta-Propanoyl-3beta-(2-naphthyl)-tropane (WF-23) is a potent cocaine analog with activity at dopamine and serotonin transporters. The purpose of these experiments was to characterize the time course of effects of acute administration of WF-23 on sp