Zobrazeno 1 - 10
of 36
pro vyhledávání: '"S R, Childers"'
Publikováno v:
Biochemical pharmacology. 62(4)
The efficacy of heroin metabolites for the stimulation of mu opioid receptor-mediated G-protein activation was investigated using agonist-stimulated [(35)S]guanosine-5'-O-(gamma-thio)-triphosphate binding. In rat thalamic membranes, heroin and its pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14309c1cdbb15f763e4cceb5be587e38
https://pubmed.ncbi.nlm.nih.gov/11448454
https://pubmed.ncbi.nlm.nih.gov/11448454
Autor:
H M, Davies, V, Gilliatt, L A, Kuhn, E, Saikali, P, Ren, P S, Hammond, T, Sexton, S R, Childers
Publikováno v:
Journal of medicinal chemistry. 44(10)
A series of 3beta-naphthyltropane derivatives were synthesized and found to show high affinity at both the dopamine and serotonin transporter sites, leading to some of the most potent inhibitors known based on the tropane structure. Comparative molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8758818fe6a48739991b189f98825c55
https://pubmed.ncbi.nlm.nih.gov/11334561
https://pubmed.ncbi.nlm.nih.gov/11334561
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(4)
3Beta-(5-indolyl)-8-azabicyclo[3.2.1]octanes display potent binding affinity for both the dopamine and serotonin transporters, while certain 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicyclo[3.2.1]octanes selectively bind to the serotonin transporter.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc367daeba6ed69825246daecc5312d5
https://pubmed.ncbi.nlm.nih.gov/11229754
https://pubmed.ncbi.nlm.nih.gov/11229754
Autor:
C S, Breivogel, S R, Childers
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(1)
To investigate differences in agonist affinity, potency, and efficacy across rat brain regions, five representative cannabinoid compounds were investigated in membranes from three different rat brain regions for their ability to maximally stimulate [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14ae97a0369595bec627a69e842b9179
https://pubmed.ncbi.nlm.nih.gov/10991998
https://pubmed.ncbi.nlm.nih.gov/10991998
Autor:
R H, Mach, M A, Nader, R L, Ehrenkaufer, H D, Gage, S R, Childers, L M, Hodges, M M, Hodges, H M, Davies
Publikováno v:
Synapse (New York, N.Y.). 37(2)
A series of PET imaging studies were conducted with two fluorine-18-labeled tropane analoges, [(18)F](+)-FTT and [(18)F](+)-FCT. Both compounds possessed a high affinity and selectivity for the dopamine transporter and had a higher accumulation in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6525796ec54cf45d337d828e85e9fdf
https://pubmed.ncbi.nlm.nih.gov/10881032
https://pubmed.ncbi.nlm.nih.gov/10881032
Autor:
S R, Letchworth, H R, Smith, L J, Porrino, B A, Bennett, H M, Davies, T, Sexton, S R, Childers
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(2)
PTT (2beta-propanoyl-3beta-[4-tolyl] tropane) is a tropane analog relatively selective for dopamine transporters in binding and uptake assays in vitro, with long-acting psychostimulant properties in vivo. To explore its utility in binding to dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f8c77aba0a34aa6a1dd384168c90a83
https://pubmed.ncbi.nlm.nih.gov/10773045
https://pubmed.ncbi.nlm.nih.gov/10773045
Publikováno v:
Molecular pharmacology. 57(5)
Previous studies had shown that the amplification factors for cannabinoid receptors, defined as the number of total G proteins activated per occupied receptor, differs between several rat brain regions. In this study, we sought to determine which spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b8520c50702604496cfc899c3282c77
https://pubmed.ncbi.nlm.nih.gov/10779385
https://pubmed.ncbi.nlm.nih.gov/10779385
Publikováno v:
Neuropharmacology. 39(2)
Coupling of receptors to G-proteins can be assessed by the ability of specific agonists to stimulate [35S]GTPgammaS binding in both brain membranes and sections in the presence of excess GDP. In some brain regions, however, high basal activity makes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89d70ee0e7280436dab7b415ca705fa8
https://pubmed.ncbi.nlm.nih.gov/10670423
https://pubmed.ncbi.nlm.nih.gov/10670423
Publikováno v:
Synapse (New York, N.Y.). 35(4)
The sulfhydryl alkylating reagent N-ethylmaleimide (NEM) blocks opioid receptor binding and receptor/G-protein coupling. Sodium partially restores [(3)H]naloxone binding after inhibition by NEM to reveal sodium-dependent [(3)H]naloxone sites, defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e0ea91eaae6a5b8ec8bd6f81668e325
https://pubmed.ncbi.nlm.nih.gov/10657035
https://pubmed.ncbi.nlm.nih.gov/10657035
Autor:
S R, Letchworth, T, Sexton, S R, Childers, K E, Vrana, R A, Vaughan, H M, Davies, L J, Porrino
Publikováno v:
Journal of neurochemistry. 73(5)
This study describes a direct comparison of dopamine transporter (DAT) mRNA and protein, as well as its binding sites, in tissue from the same animals after chronic cocaine administration. Rats were treated twice daily with 25 mg/kg cocaine or with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0d0ef507ed26719aceb38752cc07d72
https://pubmed.ncbi.nlm.nih.gov/10537056
https://pubmed.ncbi.nlm.nih.gov/10537056