Zobrazeno 1 - 10
of 70
pro vyhledávání: '"S Pullamsetti"'
Autor:
N Sommer, F Droege, KE Gamen, U Geisthoff, H Gall, K Tello, MJ Richter, LM Deubner, R Schmiedel, M Hecker, E Spiekerkoetter, K Wirsching, W Seeger, HA Ghofrani, S Pullamsetti
Publikováno v:
Pulmonary Circulation, Vol 9 (2018)
Pulmonary arterial hypertension (PAH) can be found in patients suffering from a loss-of-function mutation of the gene encoding for the activin receptor-like kinase 1 (ALK-1), a bone morphogenetic protein (BMP) type 1 receptor. Interestingly, ALK-1 mu
Externí odkaz:
https://doaj.org/article/cb41cf216c6e4f02b323bc7fe6b8401d
Autor:
Matthias S. Leisegang, Jasleen Kaur Bains, Sandra Seredinski, James A. Oo, Nina M. Krause, Chao-Chung Kuo, Stefan Günther, Nevcin Sentürk Cetin, Timothy Warwick, Can Cao, Frederike Boos, Judit Izquierdo Ponce, Shaza Haydar, Rebecca Bednarz, Chanil Valasarajan, Dominik C. Fuhrmann, Jens Preussner, Mario Looso, Soni S. Pullamsetti, Marcel H. Schulz, Hendrik R. A. Jonker, Christian Richter, Flávia Rezende, Ralf Gilsbach, Beatrice Pflüger-Müller, Ilka Wittig, Ingrid Grummt, Teodora Ribarska, Ivan G. Costa, Harald Schwalbe, Ralf P. Brandes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Using a composite bioinformatics approach, the DNA:DNA:RNA triplex-forming lncRNAs HIF1α-AS1 was identified in human endothelial cells which recruits an epigenetic silencing complex to limit expression of triplex target genes.
Externí odkaz:
https://doaj.org/article/c3f7ecd225714cd98fa4bafc76a4baa2
Autor:
Jaco Selle, Katharina Dinger, Vanessa Jentgen, Daniela Zanetti, Johannes Will, Theodoros Georgomanolis, Christina Vohlen, Rebecca Wilke, Baktybek Kojonazarov, Oleksiy Klymenko, Jasmine Mohr, Silke v. Koningsbruggen-Rietschel, Christopher J. Rhodes, Anna Ulrich, Dharmesh Hirani, Tim Nestler, Margarete Odenthal, Esther Mahabir, Sreenath Nayakanti, Swati Dabral, Thomas Wunderlich, James Priest, Werner Seeger, Jörg Dötsch, Soni S. Pullamsetti, Miguel A. Alejandre Alcazar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
This study shows that maternal and perinatal obesity cause bronchial and vascular smooth muscle cell proliferation through an IL-6-FoxO1 axis, and favor thereby the emergence of bronchial obstruction and pulmonary hypertension later in life.
Externí odkaz:
https://doaj.org/article/b4419ac41c554af68c918ae4ee7c5d81
Autor:
Hebah A. Sindi, Giusy Russomanno, Sandro Satta, Vahitha B. Abdul-Salam, Kyeong Beom Jo, Basma Qazi-Chaudhry, Alexander J. Ainscough, Robert Szulcek, Harm Jan Bogaard, Claire C. Morgan, Soni S. Pullamsetti, Mai M. Alzaydi, Christopher J. Rhodes, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Martin R. Wilkins, Beata Wojciak-Stothard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regu
Externí odkaz:
https://doaj.org/article/4eebb969beec4b25a1d7906be6c74e47
Autor:
Sevdalina Nikolova, Andreas Guenther, Rajkumar Savai, Norbert Weissmann, Hossein A. Ghofrani, Melanie Konigshoff, Oliver Eickelberg, Walter Klepetko, Robert Voswinckel, Werner Seeger, Friedrich Grimminger, Ralph T. Schermuly, Soni S. Pullamsetti
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/078778e3a92d4f6a8c0ccc3ce37c3a67
Autor:
Swati Dabral, Christian Muecke, Chanil Valasarajan, Mario Schmoranzer, Astrid Wietelmann, Gregg L. Semenza, Michael Meister, Thomas Muley, Tamina Seeger-Nukpezah, Christos Samakovlis, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Rajkumar Savai, Soni S. Pullamsetti
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypert
Externí odkaz:
https://doaj.org/article/a8901cfbf7474186b10f84b921b3e98d
Autor:
Stefan Kuhnert, Siavash Mansouri, Michael A. Rieger, Rajkumar Savai, Edibe Avci, Gabriela Díaz-Piña, Manju Padmasekar, Mario Looso, Stefan Hadzic, Till Acker, Stephan Klatt, Jochen Wilhelm, Ingrid Fleming, Natascha Sommer, Norbert Weissmann, Claus Vogelmeier, Robert Bals, Andreas Zeiher, Stefanie Dimmeler, Werner Seeger, Soni S. Pullamsetti
Publikováno v:
Cells, Vol 11, Iss 13, p 2121 (2022)
Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate p
Externí odkaz:
https://doaj.org/article/7e304d43b48b447aafd57d4483baf01e
Autor:
Frederike Boos, James A. Oo, Timothy Warwick, Stefan Günther, Judit Izquierdo Ponce, Melina Lopez, Diba Rafii, Giulia Buchmann, Minh Duc Pham, Zahraa S. Msheik, Tianfu Li, Sandra Seredinski, Shaza Haydar, Sepide Kashefiolasl, Karl H. Plate, Rüdiger Behr, Matthias Mietsch, Jaya Krishnan, Soni S. Pullamsetti, Sofia-Iris Bibli, Rabea Hinkel, Andrew H. Baker, Reinier A. Boon, Marcel H. Schulz, Ilka Wittig, Francis J. Miller, Ralf P. Brandes, Matthias S. Leisegang
Publikováno v:
Basic Research in Cardiology, 118(1):5. Springer
Boos, F, Oo, J A, Warwick, T, Günther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic research in cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Boos, F, Oo, J A, Warwick, T, G?nther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R D, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S-I, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic Research in Cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Basic Research in Cardiology, 118(1):5. D. Steinkopff-Verlag
Boos, F, Oo, J A, Warwick, T, Günther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic research in cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Boos, F, Oo, J A, Warwick, T, G?nther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R D, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S-I, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic Research in Cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Basic Research in Cardiology, 118(1):5. D. Steinkopff-Verlag
Long non-coding RNAs (lncRNAs) can act as regulatory RNAs which, by altering the expression of target genes, impact on the cellular phenotype and cardiovascular disease development. Endothelial lncRNAs and their vascular functions are largely undefin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebbb1adb912075138984c27d421e77e
https://doi.org/10.1007/s00395-023-00978-3
https://doi.org/10.1007/s00395-023-00978-3
Autor:
Hamza M Al‐Tamari, Swati Dabral, Anja Schmall, Pouya Sarvari, Clemens Ruppert, Jihye Paik, Ronald A DePinho, Friedrich Grimminger, Oliver Eickelberg, Andreas Guenther, Werner Seeger, Rajkumar Savai, Soni S Pullamsetti
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 2, Pp 276-293 (2017)
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal parenchymal lung disease with limited therapeutic options, with fibroblast‐to‐myofibroblast transdifferentiation and hyperproliferation playing a major role. Investigating ex
Externí odkaz:
https://doaj.org/article/a96c5c1d6d8741a397c3c3a939c4ad46
Autor:
Steffen Kiehl, Tobias Zimmermann, Rajkumar Savai, Soni S. Pullamsetti, Werner Seeger, Marek Bartkuhn, Reinhard H. Dammann
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. It was observed that
Externí odkaz:
https://doaj.org/article/345716730072453da0e6f7e9e2f438eb