Výsledky vyhledávání

Development of a long acting human growth hormone analog suitable for once a week dosing

Autor: Ben Bolaños, Florence Brunel, Gang Chen, Rodney W. Lappe, Nebojsa Stankovic, Ryan Preston, Mark Horn, Danielle Dettling, Joselyn Del Rosario, Gary Woodnut, Moorthy S. S. Palanki, Abhijit Bhat, Annette Sievers

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:402-406

Human growth hormone was conjugated to a carrier aldolase antibody, using a novel linker by connecting a disulphide bond in growth hormone to a lysine-94 amine located on the Fab arm of the antibody. The resulting CovX body showed reduced affinity to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8534e18bf9619b917df638f2439456a5
https://doi.org/10.1016/j.bmcl.2012.11.104

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Akademický článek

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Inhibition of Nuclear Factor-κB in T Cells Suppresses Lung Fibrosis

Autor: Yukihiko Adachi, Shigenori Tamaki, Paul Erdman, Yasuhiro Sumida, Esteban C. Gabazza, Hajime Fujimoto, Koji Suzuki, Moorthy S. S. Palanki, Tatsuya Hayashi, Yutaka Yano, Osamu Taguchi, Nelson E. Bruno, Takehiro Takagi, Corina N. D’Alessandro-Gabazza

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 176:1251-1260

Cytokines secreted by T cells play a pivotal role in the pathogenesis of lung injury and fibrosis, and the transcription factors nuclear factor (NF)-kappaB and activator protein (AP)-1 are involved in the expression of cytokines from T cells during l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d3873dd21be5f3245c9020de68e78b
https://doi.org/10.1164/rccm.200609-1288oc

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Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:5546-5550

We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c3a59d9d64cb5d6108ec85b738a7b4
https://doi.org/10.1016/j.bmcl.2006.08.035

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The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of In vitro and In vivo studies

Autor: Moorthy S. S. Palanki, Lynn J. Ransone, Minghuan Ren, Ryuichi Totsuka, Sonal Desai, Arnie Ow, Paul Erdman, Peter W. Tsao, Cheryl Spooner, Brydon L. Bennett, Mark J. Suto, Wataru Toriumi, Anthony M. Manning

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:4077-4080

We have developed novel orally active quinazoline analogues as inhibitors of AP-1 and NF-κB mediated transcriptional activation. Among the derivatives prepared, 1-[2-(2-thienyl)quinazolin-4-ylamino]-3-methyl-3-pyrroline-2,5-dione ( 10 ) showed signi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53dea96edefc7cf5e62bc9d946524597
https://doi.org/10.1016/j.bmcl.2003.08.047

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Inhibitors of AP-1 and NF-κB Mediated Transcriptional Activation: Therapeutic Potential in Autoimmune Diseases and Structural Diversity

Autor: Moorthy S. S. Palanki

Publikováno v: Current Medicinal Chemistry. 9:219-227

Cytokines and chemokines play a very important role in a number of inflammatory diseases. In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76274d3c409cf8337bf8f9601afa62f3
https://doi.org/10.2174/0929867023371265

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The Effect of a T Cell-Specific NF-κB Inhibitor on In Vitro Cytokine Production and Collagen-Induced Arthritis

Autor: Gary S. Firestein, David L. Boyle, Paul P. Tak, Lynn J. Ransone, Zuoning Han, Danielle M. Gerlag, Moorthy S. S. Palanki, Anthony M. Manning, Miguel Barbosa

Publikováno v: The Journal of Immunology. 165:1652-1658

NF-κB plays a key role in the production of cytokines in inflammatory diseases. The effects of a novel T cell-specific NF-κB inhibitor, SP100030, were evaluated in cultured Jurkat cells and in murine collagen-induced arthritis (CIA). Chemical libra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e925a276ddd6bdb6d8b56021c2d30483
https://doi.org/10.4049/jimmunol.165.3.1652

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