Zobrazeno 1 - 10
of 10
pro vyhledávání: '"S P Moyes"'
Autor:
B R Maziak, Marianne Brüggemann, Rizgar A. Mageed, C.G. Mackworth-Young, S P Moyes, Ian J. Harmer, S.L. Wynn
Publikováno v:
Clinical and Experimental Immunology. 123:1-8
SUMMARYTo formulate a ‘logic’ for how a single immunoglobulin variable region gene generates antibodies with different antigen specificity and polyreactivity, we analysed chimeric antibodies produced in transgenic mice carrying the germ-line huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bf5d5b16d0840f97d815a2f47b7931
https://doi.org/10.1046/j.1365-2249.2001.01380.x
https://doi.org/10.1046/j.1365-2249.2001.01380.x
Publikováno v:
Immunology. 98:123-136
The presence of clonally-related B-lymphocyte aggregates within synovial lining tisue of rheumatoid arthritis (RA) patients suggests a germinal centre-like reaction, which may hold implications for disease pathogenesis and the causes of chronic infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5a9f143ccba4f7ff640c65dce678c8e
https://doi.org/10.1046/j.1365-2567.1999.00841.x
https://doi.org/10.1046/j.1365-2567.1999.00841.x
Autor:
Alexander Annenkov, C Herman, K Triantaphyllopoulos, David Baker, Rizgar A. Mageed, David Gould, J L Croxford, Yuti Chernajovsky, Osvaldo L. Podhajcer, Hanna Dreja, S P Moyes
Publikováno v:
Drugs & Aging. 12:29-41
Current understanding of the pathogenesis of rheumatoid arthritis has provided evidence that therapeutic benefit can be achieved by using antagonists targeted to the inflammatory cytokines involved, mainly tumour necrosis factor-alpha and interleukin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190a068986f20aa54e8941159c84edd2
https://doi.org/10.2165/00002512-199812010-00004
https://doi.org/10.2165/00002512-199812010-00004
Publikováno v:
Annals of the New York Academy of Sciences. 815:296-311
Recent advances in molecular biological and human cell hybridization technology have significantly advanced the knowledge of mechanisms that underlie human rheumatoid factor (RF) production. These advances have provided insight into the etiopathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c31faa53a892a084a6f32cec612c3d
https://doi.org/10.1111/j.1749-6632.1997.tb52071.x
https://doi.org/10.1111/j.1749-6632.1997.tb52071.x
Autor:
E. Zd’árský, Ali H. Hajeer, Ravinder N. Maini, Z. Cimburek, Rizgar A. Mageed, S Ruzickova, S P Moyes, W. E. R. Ollier, Jiří Vencovský
Publikováno v:
Rheumatology (Oxford, England). 41(4)
OBJECTIVE To investigate the contribution of polymorphism in the immunoglobulin heavy chain variable region V1-69 gene set to genetic susceptibility to rheumatoid arthritis (RA) in Czech and British patients. METHODS We used V1-69 gene sequence-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b18b12540bf32536013118a2418fadf
https://pubmed.ncbi.nlm.nih.gov/11961170
https://pubmed.ncbi.nlm.nih.gov/11961170
Publikováno v:
Immunology. 98(1)
The presence of clonally-related B-lymphocyte aggregates within synovial lining tisue of rheumatoid arthritis (RA) patients suggests a germinal centre-like reaction, which may hold implications for disease pathogenesis and the causes of chronic infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44a67072b4a7202cd2a365a547ba5ceb
https://pubmed.ncbi.nlm.nih.gov/10469243
https://pubmed.ncbi.nlm.nih.gov/10469243
Publikováno v:
Clinical and experimental immunology. 113(2)
SUMMARYThe presence of germinal centre-like structures and clonotypic expansion of lymphocytes in RA synovia may indicate a site-specific immune response to local antigens, rather than passively entrapped immune cells, that sustains synovial inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815ff6bcef2b7c4dd1244e47225981d2
https://pubmed.ncbi.nlm.nih.gov/9717979
https://pubmed.ncbi.nlm.nih.gov/9717979
Publikováno v:
Idiotypes in Medicine: Autoimmunity, Infection and Cancer ISBN: 9780444828071
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1a6029fa8300f8131b7c06f5d7c4a4d
https://doi.org/10.1016/b978-044482807-1/50015-6
https://doi.org/10.1016/b978-044482807-1/50015-6
To define mechanisms of sustained activation of synovial B lymphocytes in RA, we studied hybridomas established from the local synovial B cell repertoire of two RA patients for Vκ gene expression and for antigen-binding specificity. The analyses rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3824de00aaccfe2da624b08a88947713
https://europepmc.org/articles/PMC2200487/
https://europepmc.org/articles/PMC2200487/
Publikováno v:
Immunology. 84(3)
To gain insight into the nature of B-lymphocyte responses in the synovium of rheumatoid arthritis (RA) patients, we amplified and sequenced immunoglobulin heavy-chain variable region genes expressed in seven IgM and three IgG-secreting synovial-deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90e6feeac49c692dd82d5a498ffef848
https://pubmed.ncbi.nlm.nih.gov/7751018
https://pubmed.ncbi.nlm.nih.gov/7751018