Zobrazeno 1 - 10
of 15
pro vyhledávání: '"S P, Perrine"'
Autor:
S. P. Perrine, D. V. Faller
Publikováno v:
Experientia. 49:133-137
The inherited beta-hemoglobinopathies (sickle cell disease and beta thalassemia) are the result of a mutation in the adult (beta) globin gene. The fetal globin chain, encoded by the gamma globin genes, can substitute for the mutated or defective beta
Publikováno v:
Blood. 79:1861-1868
A new hematopoietic growth factor (Steel factor) has been identified which stimulates erythroid proliferation both in vitro and in vivo. We evaluated the influence of recombinant Steel factor on hemoglobin synthesis in peripheral blood (PB) BFU-E-der
Publikováno v:
Transplant infectious disease : an official journal of the Transplantation Society. 3(3)
Lymphoproliferative disorders associated with the Epstein-Barr virus (EBV) include non-Hodgkin's lymphoma, Hodgkin's lymphoma, and "post-transplant lymphoproliferative disorders" (PTLD), which occur with immunosuppression after marrow and organ trans
Publikováno v:
Blood. 92(8)
The mechanisms by which pharmacologic agents stimulate gamma-globin gene expression in beta-globin disorders has not been fully established at the molecular level. In studies described here, nucleated erythroblasts were isolated from patients with be
Publikováno v:
The American journal of pediatric hematology/oncology. 16(1)
Stimulating expression of the normal fetal globin genes is a preferred method of ameliorating sickle cell disease and beta-thalassemia for the majority of patients in North America who do not have appropriate bone marrow donors.Due to increased survi
Autor:
N F, Olivieri, M H, Freedman, S P, Perrine, G J, Dover, B, Sheridan, D L, Essentine, R L, Nagel
Publikováno v:
Blood. 80(12)
Autor:
S P, Perrine
Publikováno v:
Seminars in perinatology. 14(5)
Autor:
S P, Perrine, B A, Miller, D V, Faller, R A, Cohen, E P, Vichinsky, D, Hurst, B H, Lubin, T, Papayannopoulou
Publikováno v:
Blood. 74:454-459
Increasing the expression of the gamma globin genes is considered a useful therapeutic approach to the beta globin diseases. Because butyrate and alpha-amino-n-butyric acid (ABA) augment gamma globin expression in normal neonatal and adult erythroid
Publikováno v:
Advances in experimental medicine and biology. 271
The developmental switch from production of fetal (gamma) to adult (beta) globin occurs on a normally set biologic clock which proceeds even if the adult (beta) globin genes are defective. Preventing or reversing the globin gene switch would be benef
Publikováno v:
The American journal of pediatric hematology/oncology. 11(3)
In order to maintain adequate circulating numbers of blood cells, the bone marrow must produce billions of cells each day and must be able to rapidly increase production by 10-20-fold in response to infection and hemorrhage. The existence of circulat