Zobrazeno 1 - 4
of 4
pro vyhledávání: '"S P, Lear"'
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 4, Pp 641-652 (1995)
The expression of several key enzymes and receptors of rat hepatic cholesterol metabolism was studied during development. Among major findings were: acyl coenzyme A:cholesterol acyltransferase, the cholesteryl ester hydrolases, cholesterol-7 alpha-hy
Externí odkaz:
https://doaj.org/article/61671da7bc3447f18f02f42ef9a6012f
Publikováno v:
Journal of Lipid Research, Vol 24, Iss 3, Pp 290-296 (1983)
HMG-CoA reductase activity can be modulated by a reversible phosphorylation-dephosphorylation with the phosphorylated form of the enzyme being inactive and the dephosphorylated form, active. Phosphatases from diverse sources, including cytosol, have
Externí odkaz:
https://doaj.org/article/dba227b37619473aa49c35fea2641193
Publikováno v:
Journal of Lipid Research, Vol 30, Iss 11, Pp 1763-1771 (1989)
The regulation of hepatic cholesterol and lipoprotein metabolism was studied in the ethinyl estradiol-treated rat in which low density lipoprotein (LDL) receptors are increased many fold. Cholesterol synthesis was reduced at both its diurnal peak and
Externí odkaz:
https://doaj.org/article/abd4a7b715584e2590faddd364202111
Autor:
W J, Pan, H, Hsu, W A, Rees, S P, Lear, F, Lee, I N, Foltz, P, Rathanaswami, K, Manchulenko, B M, Chan, M, Zhang, X Z, Xia, S K, Patel, P J, Prince, D R, Doherty, C M, Sheckler, K O, Reynhardt, C D, Krill, B J, Harder, J A, Wisler, J L, Brandvig, J L, Lynch, A A, Anderson, L C, Wienkers, D C, Borie
Publikováno v:
British journal of pharmacology. 169(1)
AMG 181 is a human anti-α4 β7 antibody currently in phase 1 and 2 trials in subjects with inflammatory bowel diseases. AMG 181 specifically targets the α4 β7 integrin heterodimer, blocking its interaction with mucosal addressin cell adhesion mole