Výsledky vyhledávání - "S P, Kunapuli"

Concurrent signaling from Galphaq- and Galphai-coupled pathways is essential for agonist-induced alphavbeta3 activation on human platelets

Autor: B Z S, Paul, G, Vilaire, S P, Kunapuli, J S, Bennett

Publikováno v: Journal of thrombosis and haemostasis : JTH. 1(4)

The integrin alphavbeta3 mediates platelet adhesion to the matrix protein osteopontin and likely is the predominant integrin mediating platelet adhesion to the matrix protein vitronectin. To address the mechanism that regulates alphavbeta3 activity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db62cb74367e9357611f1b0a5e130865
https://pubmed.ncbi.nlm.nih.gov/12871420

Zobrazit plný text záznamu

The C6-2B glioma cell P2Y(AC) receptor is pharmacologically and molecularly identical to the platelet P2Y(12) receptor

Autor: J, Jin, W, Tomlinson, I P, Kirk, Y B, Kim, R G, Humphries, S P, Kunapuli

Publikováno v: British journal of pharmacology. 133(4)

P2Y receptor activation in many cell types leads to phospholipase C activation and accumulation of inositol phosphates, while in blood platelets, C6-2B glioma cells, and in B10 microvascular endothelial cells a P2Y receptor subtype, which couples to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7090fc4f980d5d2ee7e4b0a0fb8f61b9
https://pubmed.ncbi.nlm.nih.gov/11399669

Zobrazit plný text záznamu

Potentiation of thromboxane A2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway

Autor: C, Dangelmaier, J, Jin, J B, Smith, S P, Kunapuli

Publikováno v: Thrombosis and haemostasis. 85(2)

Platelet activation results in shape change, aggregation, generation of thromboxane A2, and release of granule contents. We have recently demonstrated that secreted ADP is essential for thromboxane A2-induced platelet aggregation (J. Biol. Chem. 274:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6a38f55b7f23e6856e31aa2746828a5
https://pubmed.ncbi.nlm.nih.gov/11246558

Zobrazit plný text záznamu

Evidence for two alternatively spliced forms of phospholipase C-beta2 in haematopoietic cells

Autor: G F, Mao, S P, Kunapuli, A, Koneti Rao

Publikováno v: British journal of haematology. 110(2)

Alternatively spliced forms have been reported for several phospholipase C (PLC) isozymes, but not for PLC-beta2, the most abundant PLC-beta in platelets. PLC-beta2 cDNA cloned from the HL-60-cell cDNA library is 3543 bases long, coding for 1181 amin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0345e3adc20ae50104198aff12c0c9e6
https://pubmed.ncbi.nlm.nih.gov/10971398

Zobrazit plný text záznamu

The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets

Autor: C, Dangelmaier, J, Jin, J L, Daniel, J B, Smith, S P, Kunapuli

Publikováno v: European journal of biochemistry. 267(8)

U46619, a thromboxane A2 mimetic, but not ADP, caused activation of p38 mitogen activated protein (MAP) kinase in aspirin-treated platelets. In nonaspirinated human platelets ADP activated p38 MAP kinase in both a time-and concentration-dependent man

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcb47854192cee83ed05a0fa7c8229d5
https://pubmed.ncbi.nlm.nih.gov/10759852

Zobrazit plný text záznamu

Role of intracellular signaling events in ADP-induced platelet aggregation

Autor: J L, Daniel, C, Dangelmaier, J, Jin, Y B, Kim, S P, Kunapuli

Publikováno v: Thrombosis and haemostasis. 82(4)

Human platelets express two distinct G protein-coupled ADP receptors, one coupled to phospholipase C through Gq, P2Y1, and the other to inhibition of adenylyl cyclase through Gi, P2TAC. We have recently shown that concomitant intracellular signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::184d7c52a111132037822e81c7a3a93e
https://pubmed.ncbi.nlm.nih.gov/10544922

Zobrazit plný text záznamu

Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors

Autor: B Z, Paul, J, Jin, S P, Kunapuli

Publikováno v: The Journal of biological chemistry. 274(41)

Thromboxane A(2) is a positive feedback lipid mediator produced following platelet activation. The G(q)-coupled thromboxane A(2) receptor subtype, TPalpha, and G(i)-coupled TPbeta subtype have been shown in human platelets. ADP-induced platelet aggre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b702ffa40daab009deac150c0a72ce12
https://pubmed.ncbi.nlm.nih.gov/10506165

Zobrazit plný text záznamu

Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change

Autor: B Z, Paul, J L, Daniel, S P, Kunapuli

Publikováno v: The Journal of biological chemistry. 274(40)

Platelets undergo shape change upon activation with agonists. During shape change, disc-shaped platelets turn into spiculated spheres with protruding filopodia. When agonist-induced cytosolic Ca(2+) increases were prevented using the cytosolic Ca(2+)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d44bebc34ca7f5b4e18451441289d29
https://pubmed.ncbi.nlm.nih.gov/10497186

Zobrazit plný text záznamu

Glucose uptake by C6 glioma cells is mediated by G(q alpha)

Autor: S P, Singh, Y, Gao, S P, Kunapuli, R, Ravindra

Publikováno v: Neuroreport. 9(1)

The role of G proteins in glucose uptake was investigated using C6 glioma cells. Carbachol (an agonist acting via G protein coupled receptors) and 5'-guanylylimidodiphosphate (Gpp(NH)p; a nonhydrolysable guanine nucleotide analog which bypasses the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c402e3a63c1b86063836ce96ddceac09
https://pubmed.ncbi.nlm.nih.gov/9592059

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání