Zobrazeno 1 - 10
of 19
pro vyhledávání: '"S P, Eisenberg"'
Publikováno v:
The Journal of Immunology. 149:2000-2007
To study the molecular mechanisms involved in transcriptional regulation of the human IL-1R antagonist (IL-1ra) we have isolated 1680-bp of 5'-flanking region DNA from the IL-1ra gene. This region of DNA was sequenced and cloned into the luciferase e
Autor:
W Conca, H G Welgus, Steven R. Goldring, P Seckinger, Jean-Michel Dayer, M Aoun-Wathne, S P Eisenberg, Philip E. Auron, N Bennett, Stephen M. Krane
Publikováno v:
Journal of Biological Chemistry. 266:16265-16268
Substitution of glycine for arginine at position 127 of the mature human interleukin 1 beta protein generates a mutant IL-1 beta protein (IL-1 beta R----G) which binds cellular IL-1 receptors with high affinity but fails to elicit significant prolife
Autor:
P Q, Liu, E J, Rebar, L, Zhang, Q, Liu, A C, Jamieson, Y, Liang, H, Qi, P X, Li, B, Chen, M C, Mendel, X, Zhong, Y L, Lee, S P, Eisenberg, S K, Spratt, C C, Case, A P, Wolffe
Publikováno v:
The Journal of biological chemistry. 276(14)
We have mapped conserved regions of enhanced DNase I accessibility within the endogenous chromosomal locus of vascular endothelial growth factor A (VEGF-A). Synthetic zinc finger protein (ZFP) transcription factors were designed to target DNA sequenc
Publikováno v:
Blood. 90(3)
Infection of monocytes with human immunodeficiency virus type 1(Ba-L) (HIV-1(Ba-L)) is significantly inhibited by treatment with the serine protease inhibitor, secretory leukocyte protease inhibitor (SLPI). SLPI does not appear to act on virus direct
Autor:
R J, Evans, J, Bray, J D, Childs, G P, Vigers, B J, Brandhuber, J J, Skalicky, R C, Thompson, S P, Eisenberg
Publikováno v:
The Journal of biological chemistry. 270(19)
Interleukin-1 receptor antagonist (IL-1ra), an IL-1 family member, binds with high affinity to the type I IL-1 receptor (IL-1RI), blocking IL-1 binding but not inducing an IL-1-like response. Extensive site-directed mutagenesis has been used to ident
Autor:
F, Cominelli, M, Bortolami, T T, Pizarro, L, Monsacchi, M, Ferretti, M T, Brewer, S P, Eisenberg, R K, Ng
Publikováno v:
The Journal of biological chemistry. 269(9)
Genomic and cDNA clones for rabbit interleukin-1 receptor antagonist (IL-1ra) were isolate based on homology with the human, mouse, and rat IL-1ra gene. A partial genomic clone, obtained by screening a rabbit genomic library, contained coding sequenc
Publikováno v:
Cancer research. 53(17)
Sustained release or high levels of interleukin-1 (IL-1) and/or tumor necrosis factor (TNF), as observed after endotoxin challenge, can produce a variety of toxicities. Naturally occurring inhibitors to IL-1 and TNF, IL-1 receptor antagonist (IL-1ra)
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 149(6)
To study the molecular mechanisms involved in transcriptional regulation of the human IL-1R antagonist (IL-1ra) we have isolated 1680-bp of 5'-flanking region DNA from the IL-1ra gene. This region of DNA was sequenced and cloned into the luciferase e
Publikováno v:
The Journal of biological chemistry. 266(30)
We have examined the binding of human and rodent interleukin-1 receptor antagonist (IL-1ra) to the type II IL-1 receptor on the human B cell line, Raji, on the mouse pre-B cell line, 70Z/3, and on human polymorphonuclear leukocytes (PMNs). Human IL-1
Autor:
W, Conca, P E, Auron, M, Aoun-Wathne, N, Bennett, P, Seckinger, H G, Welgus, S R, Goldring, S P, Eisenberg, J M, Dayer, S M, Krane
Publikováno v:
The Journal of biological chemistry. 266(25)
Substitution of glycine for arginine at position 127 of the mature human interleukin 1 beta protein generates a mutant IL-1 beta protein (IL-1 beta R----G) which binds cellular IL-1 receptors with high affinity but fails to elicit significant prolife