Zobrazeno 1 - 10
of 43
pro vyhledávání: '"S P, Becerra"'
Autor:
Alexandra Bernardo-Colón, Lijin Dong, Mones Abu-Asab, Richard S. Brush, Martin-Paul Agbaga, S. Patricia Becerra
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100358- (2023)
Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2) gene that codes for pigment epithelium-derived factor receptor (PEDF-R) (also known as ATGL). PEDF-R exhibits phospholipase activity that mediates the neurotrophi
Externí odkaz:
https://doaj.org/article/e6edfbfcaeb9463cb8396dbeb2decb19
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Retinal and choroidal inflammatory lesions increase the levels of the pro-inflammatory cytokine interleukin-6 (IL-6). Pigment epithelium-derived factor (PEDF) has anti-inflammatory properties, but it is not known if it can prevent the production of I
Externí odkaz:
https://doaj.org/article/83d777ab535646b0b164fe11e7a88838
Autor:
Jessica S. Gutiérrez-Becerra, Daniela Gordillo-Bastidas, Paulina S. López-Aguirre, Erika V. Zañudo-Angulo, Joanna J. López-Sandoval
Publikováno v:
Revista Mexicana de Endocrinología, Metabolismo y Nutrición, Vol 9, Iss 2 (2022)
Background: Obesity is a growing problem around the world, and even more so in the Western population. At present, two different pandemics collided, an Eastern-infectious disease caused by the severe acute respiratory syndrome coronavirus 2 known as
Externí odkaz:
https://doaj.org/article/17971982fbdb4992a00afba35588f4b1
Autor:
Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto‐Soler
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 13, Pp n/a-n/a (2021)
Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD pro
Externí odkaz:
https://doaj.org/article/f4461325f8d6451f97d6779225925a12
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7745 (2022)
The retinal pigment epithelium (RPE) expresses the Serpinf1 gene to produce pigment epithelium-derived factor (PEDF), a retinoprotective protein that is downregulated with cell senescence, aging and retinal degenerations. We determined the expression
Externí odkaz:
https://doaj.org/article/c6cd5e8742bd47999bc1367020bf8b65
Publikováno v:
MethodsX, Vol 7, Iss , Pp 101026- (2020)
Degeneration of the retina can lead ultimately to devastating irreversible vision loss, such as in inherited retinitis pigmentosa and age-related macular degeneration. Currently there is no cure to prevent retinal degeneration. Quantitative cell-base
Externí odkaz:
https://doaj.org/article/b5bc1149dc11466a8a44d7ecfb06b6bb
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5344 (2021)
Retinoprotective proteins play important roles for retinal tissue integrity. They can directly affect the function and the survival of photoreceptors, and/or indirectly target the retinal pigment epithelium (RPE) and endothelial cells that support th
Externí odkaz:
https://doaj.org/article/de8f0b4cc5be4287868cf385f4f9a48a
Autor:
Francisco J. Valiente-Soriano, Johnny Di Pierdomenico, Diego García-Ayuso, Arturo Ortín-Martínez, Juan A. Miralles de Imperial-Ollero, Alejandro Gallego-Ortega, Manuel Jiménez-López, M. Paz Villegas-Pérez, S. Patricia Becerra, Manuel Vidal-Sanz
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7242 (2020)
Here, we evaluated the effects of PEDF (pigment epithelium-derived factor) and PEDF peptides on cone-photoreceptor cell damage in a mouse model of focal LED-induced phototoxicity (LIP) in vivo. Swiss mice were dark-adapted overnight, anesthetized, an
Externí odkaz:
https://doaj.org/article/14d8854cb6be4b76a46297690ee53f5d
Publikováno v:
The FASEB Journal. 36
Autor:
Yujuan Wang, Preeti Subramanian, Defen Shen, Jingsheng Tuo, S. Patricia Becerra, Chi-Chao Chan
Publikováno v:
ASN Neuro, Vol 5 (2013)
AMD (age-related macular degeneration) is a neurodegenerative disease causing irreversible central blindness in the elderly. Apoptosis and inflammation play important roles in AMD pathogenesis. PEDF (pigment epithelium-derived factor) is a potent neu
Externí odkaz:
https://doaj.org/article/2059a11a3b6344189500fca19101877b