Zobrazeno 1 - 10
of 28
pro vyhledávání: '"S O Sage"'
Autor:
Alan G.S. Harper, S O Sage
Publikováno v:
Platelets in Thrombotic and Non-Thrombotic Disorders ISBN: 9783319474601
A rise in cytosolic calcium concentration ([Ca2+]cyt) is central to platelet activation. Agonists stimulate a rise in [Ca2+]cyt through a combination of Ca2+ release from intracellular stores located in the dense tubular system (DTS) and acidic organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b26403eb25cfc4b94d0c2c5b8771797
https://doi.org/10.1007/978-3-319-47462-5_21
https://doi.org/10.1007/978-3-319-47462-5_21
Autor:
S O Sage, Johan W. M. Heemskerk
Publikováno v:
Platelets. 5:295-316
Reviewed are new concepts and models of Ca(2+) signalling originating from work with various animal cells, as well as the applicability of these models to the signalling systems used by blood platelets. The following processes and mechanisms are disc
Publikováno v:
Journal of Biological Chemistry. 268:356-363
Fura-2-loaded platelets were immobilized on fibrinogen, and cytosolic free calcium concentration ([Ca2+]i) was measured by video imaging of the fluorescence signal. In the immobilized, single platelets, ADP and low doses of thrombin evoked repetitive
Publikováno v:
Scopus-Elsevier
Equine platelets in platelet-rich plasma were incubated with the fluorescent indicator dye, Fura-2-AM (Fura-2-acetoxymethyl ester) and the degree of loading of the cells with the dye and the extent of hydrolysis of the ester was assessed by quantitat
Autor:
J A, Rosado, S O, Sage
Publikováno v:
The Biochemical journal. 356(Pt 1)
Physical coupling between inositol 1,4,5-trisphosphate (IP(3)) receptors and transient receptor potential (Trp) channels has been demonstrated in both transfected and normal cells as a candidate mechanism for the activation of store-mediated Ca(2+) e
Autor:
S M, Marchenko, S O, Sage
Publikováno v:
Experimental physiology. 85(2)
The effects of osmotic stress on the cytosolic Ca2+ concentration ([Ca2+]i) in the endothelium of excised intact rat aorta were investigated using the indicator fura-2 and the patch clamp technique. Hyperosmotic stress evoked a reversible rise in end
Autor:
J A, Rosado, S O, Sage
Publikováno v:
The Biochemical journal.
In the present study we have investigated the role of inositol 1,4, 5-trisphosphate (IP(3)), functional IP(3) receptors (IP(3)Rs) and the human homologue of the Drosophila transient receptor potential (Trp) channel, human Trp1 (hTrp1), in store-media
Autor:
S O Sage, Susanne Jenner
Publikováno v:
Platelets. 11(4)
In human platelets and other non-excitable cell types depletion of the intracellular calcium stores promotes calcium entry across the plasma membrane. Although the mechanism of this store-mediated calcium entry remains uncertain, it has been suggeste
Publikováno v:
The Journal of biological chemistry. 275(11)
The nature of the mechanism underlying store-mediated Ca(2+) entry has been investigated in human platelets through a combination of cytoskeletal modifications. Inhibition of actin polymerization by cytochalasin D or latrunculin A had a biphasic time
Autor:
S M, Marchenko, S O, Sage
Publikováno v:
Experimental physiology. 85(1)
Shear stress is an important modulator of endothelial function which can affect vessel tone, endothelial morphology and gene transcription. However, the mechanism by which the endothelium detects changes in shear stress is the subject of conflicting