Zobrazeno 1 - 10
of 49
pro vyhledávání: '"S O Brennan"'
Autor:
Karl H. Weisgraber, Stanley C. Rall, Mark R. Wardell, S O Brennan, E R Nye, P M George, E D Janus
Publikováno v:
Journal of Lipid Research, Vol 31, Iss 3, Pp 535-543 (1990)
Homozygosity for the apolipoprotein (apo) E variant apoE2(158 Arg----Cys) invariably gives rise to dysbetalipoproteinemia, and when associated with obesity or a gene for hyperlipidemia, results in type III hyperlipoproteinemia. The association of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f02733cb17b8b2e71661841f8a0fd81
https://doi.org/10.1016/s0022-2275(20)43175-x
https://doi.org/10.1016/s0022-2275(20)43175-x
Publikováno v:
Clinical and laboratory haematology. 23(6)
This is the second reported example of Hb Pierre--Benite (beta90 Glu--Asp). This mutation is associated with increased oxygen affinity and polycythaemia. No instability was found and there was no charge shift detected by cellulose acetate electrophor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9596c75a2dc588f2022aa1864ce5e2e6
https://pubmed.ncbi.nlm.nih.gov/11843890
https://pubmed.ncbi.nlm.nih.gov/11843890
Publikováno v:
Thrombosis and haemostasis. 85(3)
We investigated the molecular basis of hypofibrinogenemia in a woman with a plasma fibrinogen of 1.0 mg/mL. After sequencing the coding region and intronic boundaries of all three fibrinogen genes a single heterozygous GAC--TAC mutation was identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba17621da8597c68108a3cc5643a7c1a
https://pubmed.ncbi.nlm.nih.gov/11307813
https://pubmed.ncbi.nlm.nih.gov/11307813
Publikováno v:
Thrombosis and haemostasis. 85(3)
Human fibrin has a low affinity thrombin binding site in its E domain and a high affinity binding site in the carboxy-terminal region of its variant gamma' chain (gamma'408-427). Comparison of the gamma' amino acid sequence (VRPEHPAETEYDSLYPEDDL) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68552829f919e8e3e5843a373474c82d
https://pubmed.ncbi.nlm.nih.gov/11307817
https://pubmed.ncbi.nlm.nih.gov/11307817
Publikováno v:
Thrombosis and haemostasis. 84(3)
We investigated the molecular basis of hypofibrinogenaemia in a woman with a history of recurrent, pregnancy-associated bleeding, and miscarriage. She had a Clauss fibrinogen of 0.9 mg/ml and SDS PAGE of purified fibrinogen showed a normal pattern of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::471019a7d629392d128e85c66cb20386
https://pubmed.ncbi.nlm.nih.gov/11019970
https://pubmed.ncbi.nlm.nih.gov/11019970
Publikováno v:
Blood. 96(2)
The molecular basis of a novel congenital afibrinogenemia has been determined. The proposita, the only affected member in a consanguineous Norwegian family, suffers from a moderate to severe bleeding disorder due to the total absence of any detectabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20462bd125f68bdff2c06811cd0bcbf0
https://pubmed.ncbi.nlm.nih.gov/10887149
https://pubmed.ncbi.nlm.nih.gov/10887149
Publikováno v:
The American journal of pathology. 157(1)
The proposita suffered from liver cirrhosis and biopsy showed type 1 membrane-bound fiberglass inclusions. The hepatic inclusion bodies were weakly periodic acid-Schiff diastase-positive, and on immunoperoxidase staining reacted specifically with ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82bdcda7a5d19cbc101beae17903ae11
https://pubmed.ncbi.nlm.nih.gov/10880389
https://pubmed.ncbi.nlm.nih.gov/10880389
Publikováno v:
Blood. 95(5)
We investigated the molecular basis of hypofibrinogenemia in a man with a normal thrombin clotting time. Protein analysis indicated equal plasma expression of 2 different Bbeta alleles, and DNA sequencing confirmed heterozygosity for a new Bbeta235 P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81576706b98d300e987665210c1b35e8
https://pubmed.ncbi.nlm.nih.gov/10688828
https://pubmed.ncbi.nlm.nih.gov/10688828
Publikováno v:
British journal of haematology. 108(2)
A woman with menorrhagia was investigated for a suspected fibrinogen mutation when coagulation tests revealed prolonged thrombin (55 s) and reptilase (43 s) times together with a functional and an antigenic fibrinogen concentration of 0.7 and 2.8 mg/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90e94b305ab4cfa23395a94b53df81ae
https://pubmed.ncbi.nlm.nih.gov/10691848
https://pubmed.ncbi.nlm.nih.gov/10691848
Autor:
S O, Brennan
Publikováno v:
Clinical chemistry. 44(11)
Both normal albumin (Al A) and genetically modified forms were isolated from six heterozygous subjects. Albumins from each individual were analyzed by electrospray ionization mass spectrometry (ESI MS), and the mass was compared with that predicted f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9122d8464f2b0bdd20d27b43757b081c
https://pubmed.ncbi.nlm.nih.gov/9799752
https://pubmed.ncbi.nlm.nih.gov/9799752