Výsledky vyhledávání - "S O, Sharrow"

Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing

Autor: C L Mackall, C V Bare, L A Granger, S O Sharrow, J A Titus, R E Gress

Publikováno v: The Journal of Immunology. 156:4609-4616

Thymic regenerative capacity in humans decreases with age, suggesting that thymic-independent pathways of T cell regeneration may predominate during adulthood. Using a murine bone marrow transplantation model, we present evidence that thymic-independ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ae78388ae83ba7cb1a4ed6de97dfe69
https://doi.org/10.4049/jimmunol.156.12.4609

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Quantitative differences in cell surface expression of class I MHC antigens on murine epidermal Langerhans cells

Autor: S O Sharrow, L A Barden, A Singer, S I Katz

Publikováno v: The Journal of Immunology. 153:110-116

Epidermal Langerhans cells are derived from cells of bone marrow origin and, as the primary APC population in the skin, are responsible for initiation of many immune responses. Consequently, cell surface expression of MHC Ags by Langerhans cells is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::053ec2f15366cbdb175549670070f97d
https://doi.org/10.4049/jimmunol.153.1.110

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Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells

Autor: M G Lee, S O Sharrow, A G Farr, A Singer, M C Udey

Publikováno v: The Journal of Immunology. 152:5653-5659

Cadherins mediate homotypic adhesion between lineage-related cells in epithelia and other tissues. One cadherin, E-cadherin, is also responsible for adhesion of murine epidermal Langerhans cells to keratinocytes in vitro, and may play a role in the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e2edb08f0f1826bf199a5d0eddab2de
https://doi.org/10.4049/jimmunol.152.12.5653

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T cell receptor V alpha-V beta combinatorial selection in the expressed T cell repertoire

Autor: M S Vacchio, L Granger, O Kanagawa, B Malissen, K Tomonari, S O Sharrow, R J Hodes

Publikováno v: The Journal of Immunology. 151:1322-1327

This study has evaluated whether preferential pairing occurs between TCR alpha- and beta-chains expressing specific V alpha and V beta gene products in the mature peripheral T cell population, as a result of either thymic selection or of structural c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e6cc34d35e35a290ae7fc63380301d0
https://doi.org/10.4049/jimmunol.151.3.1322

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Differential expression of VLA-alpha 4 and VLA-beta 1 discriminates multiple subsets of CD4+CD45R0+ 'memory' T cells

Autor: K J Horgan, G E Luce, Y Tanaka, T Schweighoffer, Y Shimizu, S O Sharrow, S Shaw

Publikováno v: The Journal of Immunology. 149:4082-4087

Given the importance of adhesion in T cell development, we have undertaken systematic flow cytometric analysis of CD4 T cells to determine relationships between the developmentally regulated marker CD45R0 and adhesion receptors (five VLA integrin cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f89564c74b647ae2109d0b63c9feb39
https://doi.org/10.4049/jimmunol.149.12.4082

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Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations

Autor: K S Hathcock, G Laszlo, H B Dickler, S O Sharrow, P Johnson, I S Trowbridge, R J Hodes

Publikováno v: The Journal of Immunology. 148:19-28

A mAb (I/24) has been generated that is specific for a determinant on mouse CD45 molecules. Reactivity of this mAb with a panel of CD45 transfected cell lines demonstrated that the determinant recognized is dependent upon expression of one or more CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2100b3fca35cd82219cc5d7007ab8ca8
https://doi.org/10.4049/jimmunol.148.1.19

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Expression of an unusual T cell receptor (TCR)-V beta repertoire by Ly-6C+ subpopulations of CD4+ and/or CD8+ thymocytes. Evidence for a developmental relationship between Ly-6C+ thymocytes and CD4-CD8-TCR-alpha beta+ thymocytes

Autor: Y Takahama, S O Sharrow, A Singer

Publikováno v: The Journal of Immunology. 147:2883-2891

A novel thymocyte subpopulation expressing an unusual TCR repertoire was identified by high surface expression of the Ly-6C Ag. Ly-6C+ thymocytes were distributed among all four CD4/CD8 thymocyte subsets, and represented a readily identifiable subpop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93c2f557285c8c6c71cc7d5a310e6dec
https://doi.org/10.4049/jimmunol.147.9.2883

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Repopulation of host lymphohematopoietic systems by donor cells during graft-versus-host reaction in unirradiated adult F1 mice injected with parental lymphocytes

Autor: F T Hakim, S O Sharrow, S Payne, G M Shearer

Publikováno v: The Journal of Immunology. 146:2108-2115

The graft-vs-host reaction (GVHR) generated by the injection of parental lymphocytes into unirradiated immune-competent F1 hosts is characterized by an acute loss of immune functions, an attack on host tissues, and a gradual recovery of function. Flo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c61d04617c42a9cb79b25efbf8f89907
https://doi.org/10.4049/jimmunol.146.7.2108

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Subpopulations of fetal thymocytes defined by expression of T cell receptor/CD3 and IL-2 receptor. CD3 and IL-2 receptor alpha-chain are expressed on reciprocal cell populations

Autor: R Guy, M Foo-Philips, S O Sharrow, R J Hodes

Publikováno v: The Journal of Immunology. 146:418-424

The expression of the TCR/CD3 complex and the IL-2R alpha chain (p55) on fetal thymocytes has been analyzed by flow cytometry (FCM). Two-parameter immunofluorescence identified three subpopulations which were respectively IL-2R alpha-/CD3+, IL-2R alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e47811a74657aded7dd04fcef1404bc
https://doi.org/10.4049/jimmunol.146.2.418

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Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

Autor: E, Brugnera, A, Bhandoola, R, Cibotti, Q, Yu, T I, Guinter, Y, Yamashita, S O, Sharrow, A, Singer

Publikováno v: Immunity. 13(1)

A central paradigm of T cell development is that CD4+8+ (DP) thymocytes differentiate into CD4+ or CD8+ T cells in response to intrathymic signals that extinguish transcription of the inappropriate coreceptor molecule. Contrary to this prevailing par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7c0c19fa1e3b29941d9d88d05bda273
https://pubmed.ncbi.nlm.nih.gov/10933395

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