Association Between Smoking and Molecular Subtypes of Colorectal Cancer

Autor: Steven Gallinger, Amanda E. Toland, Ulrike Peters, Wei Sun, Daniel D. Buchanan, Marios Giannakis, Shuji Ogino, Xiaoliang Wang, Tabitha A. Harrison, Jenny Chang-Claude, Efrat L. Amitay, Sonja I. Berndt, Marc J. Gunter, Li Hsu, John L. Hopper, Bethany Van Guelpen, Mingyang Song, Peter T. Campbell, Lori C. Sakoda, Andrew T. Chan, Yin Cao, Amanda I. Phipps, Barbara L. Banbury, Martha L. Slattery, Robert E. Schoen, Reiko Nishihara, Graham G. Giles, Victor Moreno, Yi Lin, S. N. Thibodeau, Polly A. Newcomb, Michael Hoffmeister, Michael O. Woods, Hermann Brenner, Mark A. Jenkins

Publikováno v: JNCI Cancer Spectrum
Dipòsit Digital de la UB
Universidad de Barcelona

Background Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted to certain molecular subtypes of CRC while large-scale comprehensive analysis is lacking. Methods A total of 9,789 CRC c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3457053c35427fa351d5ac14a4703ee4
https://pubmed.ncbi.nlm.nih.gov/34377935

Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Autor: Annette Juul Vangsted, van, Duin, M, David E. Neal, Peter Hoffmann, A Wolk, Robert J. Hamilton, Anthony J. Swerdlow, F. Wiklund, De, Ruyck, K, Paul A. Townsend, S. N. Thibodeau, Asta Försti, Esther M. John, Unnur Thorsteinsdottir, W Gregory, Niels Frost Andersen, Peter Broderick, A-K Wihlborg, Frank Claessens, Doug Easton, Kathryn L. Penney, Keith W. Muir, Jeri Kim, Jonathan S. Mitchell, Johanna Schleutker, G Cancel-Tassin, Barry S. Rosenstein, Jy Park, Hauke Thomsen, Rowan Kuiper, C West, H Gronberg, Mina Ali, CM Tangen, Obul Reddy Bandapalli, Ana Vega, Faith E. Davies, Rosalind A. Eeles, Daniel F. Gudbjartsson, Fredrick R. Schumacher, Janet L. Stanford, Paul D.P. Pharoah, Owen W. Stephens, Monique J. Roobol, Richard S. Houlston, Gudmar Thorleifsson, Christian Langer, Susan L. Neuhausen, S Chanock, G.G. Giles, Azad Razack, S Koutros, F Canzian, S Benlloch, H. Einsele, Kari Hemminki, KD Sorensen, Y-J Lu, K-T Khaw, Hareth Nahi, FC Hamdy, D Albanes, Christopher A. Haiman, Ellinor Johnsson, Amit Sud, Adam S. Kibel, Pieter Sonneveld, Florence Menegaux, Manolis Kogevinas, Nawaid Usmani, Annemiek Broyl, K. H. Jöckel, Jolanta Nickel, David W. Johnson, Aaa Olama, B.G. Nordestgaard, Amy Holroyd, Niels Weinhold, Cezary Cybulski, Sigurdur Y. Kristinsson, Radka Kaneva, Ruth C. Travis, Kari Stefansson, SI Berndt, Bowang Chen, Scott Kimber, Davor Lessel, Philip J. Law, M. M. Nöthen, Lisa A. Cannon-Albright, BE Henderson, Ni Li, Urban Gullberg, Uta Bertsch, S Weinstein, Nora Pashayan, Christiane Maier, H Brenner, Ingemar Turesson, Hardev Pandha, Thorunn Rafnar, Alison M. Dunning, Fiona M. Ross, Graham Jackson, David V. Conti, Sue A. Ingles, da, Silva, Filho, Mi, Jens Hillengass, Lisa F. Newcomb, Giulia Orlando, Brian A Walker, Teixeira, Björn Nilsson, Jenny L Donovan, Molly Went, U. H. Mellqvist, Chiara Campo, Zsofia Kote-Jarai, VL Stevens, Martin Kaiser, B-M Halvarsson, J Clements, Martin Hansson, Manuela Gago-Dominguez, EM Grindedal, Anders Waage, Julian Peto, L Mucci, Gareth J. Morgan, J Batra, H. Goldschmidt

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-3 (2019)
PRACTICAL Consortium & Townsend, P A 2019, ' Author Correction : Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma ', Nature Communications, vol. 10, no. 1, pp. 213 . https://doi.org/10.1038/s41467-018-08107-8
PRACTICAL consortium 2019, ' Author Correction : Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma ', Nature Communications, vol. 10, no. 1, 213 . https://doi.org/10.1038/s41467-018-08107-8

Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2215002bc36a38da697fc9b419d463bb
https://doi.org/10.1038/s41467-018-08107-8

Prediction of individual genetic risk to prostate cancer using a polygenic score

Autor: Cezary Cybulski, Rosalind A. Eeles, Douglas F. Easton, Robert Szulkin, Nora Pashayan, Timothy J. Key, B. E. Henderson, G.G. Giles, Hardev Pandha, Jenny L Donovan, Zsofia Kote-Jarai, Henrik Grönberg, Jong Y. Park, Johanna Schleutker, Kenneth Muir, Melissa C. Southey, Fredrick R. Schumacher, Manuel Luedeke, Markus Aly, David E. Neal, Paul D.P. Pharoah, Ruth C. Travis, Børge G. Nordestgaard, Jyotsna Batra, D J Schaid, Fredrik Wiklund, Judith A. Clements, Amanda B. Spurdle, Katja Butterbach, Lisa A. Cannon-Albright, Janet L. Stanford, Kathleen Herkommer, Adam S. Kibel, W. Vogel, Wojciech Kluźniak, Vanio Mitev, Paula Paulo, Liesel M. FitzGerald, Hermann Brenner, T A Sellers, Shannon K. McDonnell, Tammela Tlj., Lin H-Y., Freddie C. Hamdy, Ali Amin Al Olama, Jan Lubinski, Manuel R. Teixeira, C. Slavov, S. N. Thibodeau, Tom Whitington, C. Stegmaier, Andrzej M. Kierzek, Agnieszka Michael, Christiane Maier, Christopher A. Haiman, Sofia Maia, Khaw K-T., Tiina Wahlfors, Martin Eklund, Radka Kaneva, Sara Benlloch

Publikováno v: The Prostate. 75:1467-1474

BACKGROUND: Polygenic risk scores comprising established susceptibility variants have shown to be informative classifiers for several complex diseases including prostate cancer. For prostate cancer it is unknown if inclusion of genetic markers that h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3bdc3ed21f90505214d096575c0de5c
https://doi.org/10.1002/pros.23037

Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes

Autor: Steven Gallinger, Maria Elena Martinez, N. M. Lindor, Dallas R. English, Peter T. Campbell, John L. Hopper, Graeme P. Young, Loic Le Marchand, James G. Dowty, Daniel D. Buchanan, Dennis J. Ahnen, Graham Casey, Joanne P. Young, Robert W. Haile, Misty R. Jenkins, Elizabeth T. Jacobs, Aung Ko Win, John A. Baron, S. N. Thibodeau, Polly A. Newcomb, Finlay A. Macrae, Susan Parry, John D. Potter, Ingrid Winship, Lara Lipton

Publikováno v: British Journal of Cancer

Lynch syndrome, historically known as hereditary non-polyposis colorectal cancer (Jass, 2006), refers to colorectal and other cancers caused by germline mutations in DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 (Vasen et al, 1999). Appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d5a7c8af7083fcff4dfb7602221e04
https://doi.org/10.1038/bjc.2011.172

Absence ofPMS2mutations in colon-CFR participants whose colorectal cancers demonstrate unexplained loss of MLH1 expression

Autor: Steve Gallinger, Shanaka R. Gunawardena, Finlay A. Macrae, Walsh, S. N. Thibodeau, Joanne P. Young, John D. Potter, Christophe Rosty, Mark Clendenning, John L. Hopper, Robert W. Haile, Daniel D. Buchanan, Rhiannon J. Walters, Mark A. Jenkins

Publikováno v: Clinical Genetics. 83:591-593

To the Editor: Lynch syndrome (LS) (MIM#120435) is a cancer predisposition condition resulting from mutations within the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6 or PMS2). In a suspected LS family, tumors are assessed for microsatellite inst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e5bb93ca1cfd55c4d02d1f4ad13b1cf
https://doi.org/10.1111/cge.12011