Zobrazeno 1 - 10 of 54 pro vyhledávání: '"S N Sehgal"'
1
THERAPEUTIC BLOOD LEVELS OF SIROLIMUS (RAPAMYCIN) IN THE ALLOGRAFTED RAT
Autor: M Sharr, J Armstrong, S N Sehgal, John F. DiJoseph, E Fluhler
Publikováno v: Transplantation. 62:1109-1112
A study was conducted to determine the relationship among oral dose, trough whole blood levels, graft survival, and side effects in sirolimus-treated allografted rats. The heterotopic heart allograft model using Brown Norway donors and Lewis rat reci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c6eeea2a08d33378d22e5e17aedda1
https://doi.org/10.1097/00007890-199610270-00015
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2
Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome
Autor: B R Blazar, P A Taylor, D C Snover, S N Sehgal, D A Vallera
Publikováno v: The Journal of Immunology. 151:5726-5741
We investigated the ability of the macrolide antifungal agent rapamycin (RAPA) to inhibit murine graft-vs-host disease induced across the MHC barrier. An optimum dose (1.5 mg/kg) given for 14 days beginning on the day of transplant (and then three ti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0674db41cdb75b19404c2a585dade943
https://doi.org/10.4049/jimmunol.151.10.5726
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3
Functional and Histopathologic Effects of Rapamycin on Mouse Kidney
Autor: J. F. Did Joseph, S. N. Sehgal
Publikováno v: Immunopharmacology and Immunotoxicology. 15:45-56
The effect of rapamycin (RAPA) on kidney function and histopathology was assessed in two strains of mice. Male C3H/HeJ mice were treated with RAPA for 4 days at doses of 25, 50, 75, and 100 mg/kg, ip and male C3H/HeJ or female Balb/cJ mice were both
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317ce483f3d9246d5da4dd718f7e7c86
https://doi.org/10.3109/08923979309066932
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4
Compromised kidney graft rejection response in Vervet monkeys after withdrawal of immunosuppressants tacrolimus and sirolimus
Autor: H, Chen, J, Peng, H, Luo, M, Loubeau, X, Wan, D, Xu, S, Qi, M D, Vu, P, Daloze, W E, Fitzsimmons, I, Bekersky, J, Peets, S N, Sehgal, J, Wu
Publikováno v: Transplantation. 69(8)
In nonprimates, organ allografts are often not rejected after withdrawal of immunosuppression. In this study, we examined whether such a phenomenon also occurs in primates.Vervet monkeys were transplanted with renal allografts and treated for 60 days
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7f93953a67c4d6d4cebedb09a088bc2
https://pubmed.ncbi.nlm.nih.gov/10836361
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5
Tacrolimus (FK506) and sirolimus (rapamycin) in combination are not antagonistic but produce extended graft survival in cardiac transplantation in the rat
Autor: M D, Vu, S, Qi, D, Xu, J, Wu, W E, Fitzsimmons, S N, Sehgal, L, Dumont, S, Busque, P, Daloze, H, Chen
Publikováno v: Transplantation. 64(12)
Combined use of tacrolimus (FK506) with sirolimus (rapamycin [RAPA]) was examined in a model of vascularized heart allograft in the rat. For prevention of acute rejection, three different combinations of low doses of FK506 and RAPA from day 1 up to d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9aee7ad09854e09d4f873600c8159896
https://pubmed.ncbi.nlm.nih.gov/9422432
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7
Prolongation of renal allograft survival in a large animal model by oral rapamycin monotherapy
Autor: D K, Granger, J W, Cromwell, S C, Chen, J J, Goswitz, D T, Morrow, F A, Beierle, S N, Sehgal, D M, Canafax, A J, Matas
Publikováno v: Transplantation. 59(2)
We assessed the efficacy of 5 dose levels of oral rapamycin for prolonging renal allograft survival in pigs. Untreated and triple therapy groups (cyclosporine, azathioprine, and prednisone) served as controls. Immunosuppression was administered for 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d1b4b6d39fa140c3c1a2cd0495c4643
https://pubmed.ncbi.nlm.nih.gov/7839438
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8
Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow
Autor: B R, Blazar, P A, Taylor, S N, Sehgal, D A, Vallera
Publikováno v: Blood. 83(2)
We investigated the ability of the macrolide antifungal agent rapamycin (RAPA) to inhibit the rejection of T-cell-depleted (TCD) donor bone marrow (BM) transplanted into major histocompatibility complex (MHC)-disparate irradiated recipients. RAPA (1.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cc77ea6a51df69c5625b57ebda63619
https://pubmed.ncbi.nlm.nih.gov/8286755
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10
Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome
Autor: B R, Blazar, P A, Taylor, D C, Snover, S N, Sehgal, D A, Vallera
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 151(10)
We investigated the ability of the macrolide antifungal agent rapamycin (RAPA) to inhibit murine graft-vs-host disease induced across the MHC barrier. An optimum dose (1.5 mg/kg) given for 14 days beginning on the day of transplant (and then three ti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd1c7b9f494f1bacb0ea56802dda1532
https://pubmed.ncbi.nlm.nih.gov/8228258
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