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Selective up-regulation of phosphatidylinositol 3'-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 resistance from Fas-mediated apoptosis

Autor: A S, Varadhachary, M E, Peter, S N, Perdow, P H, Krammer, P, Salgame

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(9)

In this study the mechanism of differential sensitivity of CD3-activated Th1- and Th2-type cells to Fas-mediated apoptosis was explored. We show that the Fas-associated death domain protein (FADD)/caspase-8 pathway is differentially regulated by CD3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c75e0bab6436783f2e5506faf101afeb
https://pubmed.ncbi.nlm.nih.gov/10528176

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