Zobrazeno 1 - 10
of 110
pro vyhledávání: '"S N, Morozkina"'
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 1, Pp 75-80 (2024)
Introduction. The effectiveness of diflunisal in the treatment of cardiac amyloidosis has been clinically proven. Currently, only tablet forms of diflunisal are registered in the world, however, long-term use of NSAIDs leads to characteristic side ef
Externí odkaz:
https://doaj.org/article/d634d495c44c4d31a3e41826a0058a59
Autor:
M. V. Filatov, Stanislav I. Selivanov, Andrey S. Drozdov, S. N. Morozkina, R. A. Kovalev, A. G. Shavva, Ivan Gluzdikov
Publikováno v:
Russian Journal of Organic Chemistry. 51:411-416
Sulfamates derived from estrogens of the 8α-series have been synthesized, and their effect on the growth of MCF-7 breast cancer cells has been studied. The best anticancer effect has been found for 7β-methyl-D-homo-6-oxa-8α-estrone sulfamate and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe557dd26df7e7df5241bb24b9f22ec
https://doi.org/10.1134/s1070428015030215
https://doi.org/10.1134/s1070428015030215
Autor:
L I Zacharova, O. V. Galkina, S. N. Morozkina, A. G. Shavva, F E Putilina, N D Eschenko, V A Vilkova, A. F. Fidarov
Publikováno v:
Biomeditsinskaya Khimiya. 61:724-730
The aim of this work was to study the ability of some estrogen 8α-analogues, that have CH3-group in the C-3 position, exhibit osteoprotective and cholesterolemic effects. The properties of these analogues was comparisoned with effects of native estr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d76e0d24f13258e842d6471125cf50
https://doi.org/10.18097/pbmc20156106724
https://doi.org/10.18097/pbmc20156106724
Autor:
Alexander G. Shavva, Galina L. Starova, Andrei A. Zolotarev, Roman P. Bogautdinov, A. F. Fidarov, Stanislav I. Selivanov, S. N. Morozkina
Publikováno v:
Journal of Fluorine Chemistry. 168:218-222
Two steroid estrogens, natural estradiol and 8α-estradiol, were fluorinated using Selectfluor® in ionic liquid. Unexpectedly, mostly products of fluorination at position C-10 were isolated instead of corresponding fluorophenols, as it was reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d79369b4d6bba1b59c94ef965a0d644
https://doi.org/10.1016/j.jfluchem.2014.09.030
https://doi.org/10.1016/j.jfluchem.2014.09.030
Publikováno v:
Steroids. 88:90-94
To investigate the relationship between structure and biological activity of analogues of steroid estrogens we have developed the synthesis of 7α-methyl-6-oxa-estra-1,3,5(10),8(9)-tetraenes with cis- and trans-junction of C and D rings. We found tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769e69157b398d162e04dfb21b977505
https://doi.org/10.1016/j.steroids.2014.05.006
https://doi.org/10.1016/j.steroids.2014.05.006
Publikováno v:
Russian Journal of Organic Chemistry. 50:1520-1526
New 8α-analogs of steroidal estrogens containing a fluorine atom in the 2-position have been synthesized with the goal of obtaining modified derivatives with improved biological characteristics. Some of the synthesized compounds have been found to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56ca6cb6f31318627eac44f809202803
https://doi.org/10.1134/s1070428014100182
https://doi.org/10.1134/s1070428014100182
Publikováno v:
Russian Journal of General Chemistry. 84:1716-1721
Procedure of preparation of 7β-methyl-D-homo-6-oxa-1,3,5(10),8,(9)-estratetraen-17a-one methyl ether has been developed; the product conformation in the solution has been studied by NMR spectroscopy. Comparison of the experimental data with simulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed71262103bebc62ed216793b4af238b
https://doi.org/10.1134/s1070363214090138
https://doi.org/10.1134/s1070363214090138
Autor:
S. N. Morozkina, A. G. Shawa, A. F. Fidarov, A. S. Mushtukov, Stanislav I. Selivanov, Galina L. Starova
Publikováno v:
Russian Journal of General Chemistry. 83:1869-1873
In order to estimate the potential of steroid estrogens modification, three D-homoanalogs of estrogens have been prepared; their structures and biological properties have been studied. The expansion of D-ring in such compounds has lead to strong decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac078f53162eaae5673f10b27a67ceab
https://doi.org/10.1134/s1070363213100125
https://doi.org/10.1134/s1070363213100125
Publikováno v:
Russian Journal of Organic Chemistry. 49:603-609
8α-Analogs of steroidal estrogens containing a methyl group on C1 or an oxo group on C6 were synthesized with a view to obtain compounds exhibiting selective biological activity, and their steric structure was studied. As shown with 1,3-O-dimethyl-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab616d5fbc643b43722462a512f2e9c
https://doi.org/10.1134/s1070428013040180
https://doi.org/10.1134/s1070428013040180