Zobrazeno 1 - 10
of 24
pro vyhledávání: '"S N, Lavrenov"'
Autor:
Alexey S Trenin, Elena P. Mirchink, S. N. Lavrenov, Elena B. Isakova, Alexey A. Panov, Alexander M. Korolev
Publikováno v:
The Journal of Antibiotics. 74:219-224
A series of new compounds—arylbis(indol-3-yl)methylium derivatives—were synthesized and their antimicrobial activity was evaluated. All the compounds turned out to be highly active, with MIC depending on their structure and the length of N-alkyl
Autor:
Alexey A. Panov, Eugeny E. Bykov, Alexey S Trenin, S. N. Lavrenov, Alexander Y. Simonov, Alexander M. Korolev
Publikováno v:
MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE.
The difference in the reactivity of maleimide derivatives is explained by the method of calculating partial charges on carbon atoms of 3-substituted-4-bromomaleimides, as well as by 3D molecular modeling. The influence of various substituents on the
Publikováno v:
Acta Naturae
The effects of new synthetic antibacterial agents - tris(1-pentyl-1H-indol-3-yl)methylium chloride (LCTA-1975) and (1-(4-(dimethylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-3-yl)bis(1-propyl- 1H-indol-3-yl)methylium chloride (LCTA-2701 - o
Autor:
Andrei L. Okorokov, Poroikov, C. Spinnler, Vera V. Grinkevich, Elisabeth Hedström, Perdita E. Barran, Joanna Zawacka-Pankau, Aparna Vema, Natalia Issaeva, Mikhail Burmakin, Alberto Inga, Eleanor R. Dickinson, Maria N. Preobrazhenskaya, Galina Selivanova, Olga Tarasova, S. N. Lavrenov, Fawkner K, Anders Karlén, Lars Larsson, Andreotti
Given the immense significance of p53 restoration for anti-cancer therapy and that p53-activating molecules are in clinical trials, elucidation of the mechanisms of action of p53-activating molecules is of the utmost importance. Here we report a disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075188e35e1d954df35a13045e3fc84a
Autor:
Galina Selivanova, S. N. Lavrenov, C. Spinnler, Vera V. Grinkevich, Natalia Issaeva, Alberto Inga, Margareta Wilhelm, Eleanor R. Dickinson, Karin Ridderstråle, Maria N. Preobrazhenskaya, Andrei L. Okorokov, Joanna Zawacka-Pankau, Olga Tarasova, Virginia Andreotti, Mikhail Burmakin, Perdita E. Barran, Aparna Vema, Anders Karlén, Elisabeth Hedström, Vladimir Poroikov, Lars-Gunnar Larsson
Publikováno v:
SSRN Electronic Journal.
Given the immense significance of p53 restoration for anti-cancer therapy, elucidation of the mechanisms of action of p53-activating molecules is of the utmost importance. Here we report a discovery of a novel allosteric modulation of p53 by small mo
Autor:
S. N. Lavrenov, Angelica V. Sharapova, Marina V. Ol’khovich, German L. Perlovich, Svetlana V. Blokhina
Publikováno v:
Fluid Phase Equilibria. 384:68-72
Complexation processes in the systems of 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) – pharmacologically active substances within the temperature range of 293–315 K were studied by the UV-spectroscopy method. 2HP-β-CD was shown to improve the so
Autor:
Kevin M. Poindexter, Ida Aronchik, Janice H Xu, S. N. Lavrenov, Thomas M. Tomasiak, Gary L. Firestone, Jeanne G. Quirit, Yaroslav A. Solomatin, Maria N. Preobrazhenskaya, Kathleen A. Durkin, Christine K. Kyauk
Publikováno v:
Biochemical pharmacology. 127
The HECT domain-containing E3 ubiquitin ligase NEDD4-1 (Neural precursor cell Expressed Developmentally Down regulated gene 4-1) is frequently overexpressed in human cancers and displays oncogenic-like properties through the ubiquitin-dependent regul
Publikováno v:
Chemistry of Heterocyclic Compounds. 47:1225-1229
Quantum-chemical calculations have been carried out of heterolytic dissociation energies of a series of tri(1H-indol-3-yl)methylium compounds with different counter-ions within the framework of density functional theory, using the functional B3LYP in
Publikováno v:
Chemistry of Heterocyclic Compounds. 46:1233-1238
The total energies of reactants, products, and transition states of nucleophilic substitution reactions in protonated tris(indol-3-yl)methane have been assessed with the semiempirical AM1 method and the theory of functional density B3LYP/6-31(d) meth
Autor:
M. I. Reznikova, Valeria A. Glazunova, Victor V. Tatarsky, Maria N. Preobrazhenskaya, Evgeniy E. Bykov, S. N. Lavrenov, Evgenia V. Stepanova, Yulia L. Volodina, Yuriy N. Luzikov, Alexander A. Shtil
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:6905-6913
Novel derivatives of tris(indol-3-yl)methane and tris(indol-3-yl)methylium salts with the alkyl substituents at the N-atoms of the indole rings were synthesized. An easy substitution of indole rings in trisindolylmethanes for other indoles under the