Zobrazeno 1 - 10
of 10
pro vyhledávání: '"S Michelle Morin"'
Publikováno v:
Cephalalgia. 39:1241-1248
Objective The objective of this investigation was to examine the distribution of galcanezumab and a control immunoglobulin 4 antibody containing the same constant regions as galcanezumab, into peripheral and central tissues. Methods Galcanezumab and
Autor:
Peter J. Lindsay-Scott, Victor W. Pike, J. Craig Ruble, Maria Cuadrado, Mohammad B. Haskali, Michael P. Johnson, Susan DuBois, Nancy Kant, Hugh Nuthall, Shuiyu Lu, Jeremy Gilmore, Kevin Michael Ruley, Aneta Kowalski, Enrique Jambrina, S Michelle Morin, Adrian J. Mogg, Soumen Paul, Andrew J. Mannes, Jeih-San Liow, Vanessa N. Barth, Cheryl L. Morse, Sami S. Zoghbi, Nicolas Dreyfus, Robert L. Gladding, Cynthia Darshini Jesudason, Robert B. Innis, Sergey Shcherbinin
Publikováno v:
Science Translational Medicine. 12
We aimed to develop effective radioligands for quantifying brain O-linked-β-N-acetyl-glucosamine (O-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as tools for evaluating drug target engagement. Posttranslational modif
Autor:
Shuiyu, Lu, Mohammad B, Haskali, Kevin M, Ruley, Nicolas J-F, Dreyfus, Susan L, DuBois, Soumen, Paul, Jeih-San, Liow, Cheryl L, Morse, Aneta, Kowalski, Robert L, Gladding, Jeremy, Gilmore, Adrian J, Mogg, S Michelle, Morin, Peter J, Lindsay-Scott, J Craig, Ruble, Nancy A, Kant, Sergey, Shcherbinin, Vanessa N, Barth, Michael P, Johnson, Maria, Cuadrado, Enrique, Jambrina, Andrew J, Mannes, Hugh N, Nuthall, Sami S, Zoghbi, Cynthia D, Jesudason, Robert B, Innis, Victor W, Pike
Publikováno v:
Sci Transl Med
We aimed to develop effective radioligands for quantifying brain O-linked-β-N-acetyl-glucosamine (O-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as tools for evaluating drug target engagement. Post-translational modi
Autor:
David C. DeRosa, Angela J. Okragly, Kirk W. Johnson, Michael P. Johnson, Andrea P. Martin, Robert J. Benschop, S Michelle Morin
Publikováno v:
Cephalalgia : an international journal of headache. 38(9)
Background Many patients with migraines suffer from allergies and vice versa, suggesting a relationship between biological mechanisms of allergy and migraine. It was proposed many years ago that mast cells may be involved in the pathophysiology of mi
Autor:
Junliang Hao, Wesley H. Anderson, Cohen Michael Philip, Kjell A. Svensson, Michael A. Statnick, Donald R. Gehlert, Joseph H. Krushinski, Hellman Sarah Lynne, Michelle M Menezes, Jeffrey W Cramer, Julie F. Falcone, Xushan Wang, Rebecca A. Wright, John Mehnert Schaus, Neil W. DeLapp, Reinhard Matthew Robert, S Michelle Morin, Charles R. Yang, Todd R. Wiernicki, Ilya Okun, Renee Emkey, Benjamin L. Adams, Beverly A. Heinz, Brian G. Getman, James P. Beck, Robert F. Bruns, Virginia L. Lucaites, Todd M. Suter, Deanna L Maren, David L. Nelson, Kelly L. Knopp, Borys V. Rogovoy
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 341:672-680
Corticotropin-releasing factor (CRF) is the major hypothalamic neuropeptide responsible for stimulation of the hypothalamic-pituitary-adrenal axis (HPAA), resulting in the synthesis and release of glucocorticoids from the adrenal cortex. In a recent
Autor:
Stephanie D. Fitz, Charity Zink, Janice Shaw, Anantha Shekhar, Tammy J. Sajdyk, Susan L. Gackenheimer, Phillip A. Hipskind, S Michelle Morin, Donald R. Gehlert
Publikováno v:
European Journal of Pharmacology. 509:145-153
Corticotropin releasing factor (CRF) and Urocortin are important neurotransmitters in the regulation of physiological and behavioral responses to stress. Centrally administered CRF or Urocortin produces anxiety-like responses in numerous animal model
Autor:
John H. Heiligenstein, S Michelle Morin, Kenneth W. Perry, David L. Nelson, Frank P. Bymaster, Susan K. Hemrick-Luecke, Penny G. Threlkeld, Jason Katner, Donald R. Gehlert
Publikováno v:
Neuropsychopharmacology. 27:699-711
The selective norepinephrine (NE) transporter inhibitor atomoxetine (formerly called tomoxetine or LY139603) has been shown to alleviate symptoms in Attention Deficit/Hyperactivity Disorder (ADHD). We investigated the mechanism of action of atomoxeti
Autor:
Donald R. Gehlert, S Michelle Morin
Publikováno v:
Journal of molecular neuroscience : MN. 29(2)
The pharmacology and brain mRNA distribution of the neuropeptide Y (NPY) rat Y5 (rY5) receptor has led to the hypothesis that this receptor might mediate the hypothalamic feeding response to NPY in addition to many other physiologic functions. Howeve
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