Zobrazeno 1 - 10
of 202
pro vyhledávání: '"S Michal Jazwinski"'
Publikováno v:
Frontiers in Genetics, Vol 5 (2015)
It is widely accepted that aging is characterized by a gradual decline in the efficiency and accuracy of biological processes, leading to deterioration of physiological functions and development of age-associated diseases. Age-dependent accumulation
Externí odkaz:
https://doaj.org/article/6995bba76cf34864b01c55cea80e9ee4
Autor:
Srinivas eAyyadevara, Cagdas eTazearslan, Ramani eAlla, James C Jiang, S Michal Jazwinski, Robert Joseph Shmookler Reis
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
A quantitative trait locus (QTL) in the nematode C. elegans, lsq4, was recently implicated by mapping longevity genes. QTLs for lifespan and 3 stress-resistance traits coincided within a span of
Externí odkaz:
https://doaj.org/article/00abac1825fa48e8985c4b58aea9a9d0
Autor:
Deepika Malik, Tiffany Hsu, Payam Falatoonzadeh, Javier Cáceres-del-Carpio, Mohamed Tarek, Marilyn Chwa, Shari R Atilano, Claudio Ramirez, Anthony B Nesburn, David S Boyer, Baruch D Kuppermann, S Michal Jazwinski, Michael V Miceli, Douglas C Wallace, Nitin Udar, M Cristina Kenney
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e99003 (2014)
It has been recognized that cells do not respond equally to ultraviolet (UV) radiation but it is not clear whether this is due to genetic, biochemical or structural differences of the cells. We have a novel cybrid (cytoplasmic hybrids) model that all
Externí odkaz:
https://doaj.org/article/9f2ccfb6cc0d49d39cf771ce7acbda7a
Autor:
M Cristina Kenney, Marilyn Chwa, Shari R Atilano, Janelle M Pavlis, Payam Falatoonzadeh, Claudio Ramirez, Deepika Malik, Tiffany Hsu, Grace Woo, Kyaw Soe, Anthony B Nesburn, David S Boyer, Baruch D Kuppermann, S Michal Jazwinski, Michael V Miceli, Douglas C Wallace, Nitin Udar
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54339 (2013)
Mitochondrial dysfunction is associated with the development and progression of age-related macular degeneration (AMD). Recent studies using populations from the United States and Australia have demonstrated that AMD is associated with mitochondrial
Externí odkaz:
https://doaj.org/article/1e6297845c0d4c1bbfd598fd15860ca7
Autor:
Gauri A Patwardhan, Qian-Jin Zhang, Dongmei Yin, Vineet Gupta, Jianxiong Bao, Can E Senkal, Besim Ogretmen, Myles C Cabot, Girish V Shah, Paul W Sylvester, S Michal Jazwinski, Yong-Yu Liu
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6938 (2009)
Enhanced ceramide glycosylation catalyzed by glucosylceramide synthase (GCS) limits therapeutic efficiencies of antineoplastic agents including doxorubicin in drug-resistant cancer cells. Aimed to determine the role of GCS in tumor response to chemot
Externí odkaz:
https://doaj.org/article/4a8c26fe191b4634aace87a39c6118ad
Autor:
Sangkyu Kim, Jessica Fuselier, Anna Latoff, Justin Manges, S. Michal Jazwinski, Andrea Zsombok
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Various risk factors of Alzheimer’s disease (AD) are known, such as advanced age, possession of certain genetic variants, accumulation of toxic amyloid-β (Aβ) peptides, and unhealthy lifestyle. An estimate of heritability of AD ranges fr
Externí odkaz:
https://doaj.org/article/ec1cddffcbb94e53b06d9915a8717bf4
Autor:
Sangkyu Kim, Jessica Fuselier, Anna Latoff, Justin Manges, S. Michal Jazwinski, Andrea Zsombok
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f06e2d16b36048a09357b06f03361201
Autor:
Qiuyang Zhang, S. Michal Jazwinski
Publikováno v:
Cancers, Vol 14, Iss 21, p 5185 (2022)
Cancer is a disease of aging, but most studies on cancer are in young but not aged animal models, and cancer clinical trials are rarely performed in older adults. Recognition of the connections between aging and cancer and improvement of treatment fo
Externí odkaz:
https://doaj.org/article/5d64607bf6774397bee8b6442e7672a3
Autor:
Kevin Schneider, Marilyn Chwa, Shari R. Atilano, Sonali Nashine, Nitin Udar, David S. Boyer, S. Michal Jazwinski, Michael V. Miceli, Anthony B. Nesburn, Baruch D. Kuppermann, M. Cristina Kenney
Publikováno v:
FASEB BioAdvances. 4:675-689
Activation of the Simulator of Interferon Genes (STING) system by mitochondrial (mt) DNA can upregulate type 1 interferon genes and enhance immune responses to combat bacterial and viral infections. In cancers, the tumor-derived DNA activates STING l
Tumor suppressor p53 plays an essential role in protecting cells from malignant transformation by inducing cell-cycle arrest and apoptosis. Mutant p53 that is detected in more than 50% of cases of cancers loses its role in suppression of tumors but g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156a82a833afdd368b89bbaedb0496ed
https://doi.org/10.1158/0008-5472.c.6502785.v1
https://doi.org/10.1158/0008-5472.c.6502785.v1