Zobrazeno 1 - 10
of 460
pro vyhledávání: '"S Mattar"'
Publikováno v:
Revista de la Facultad de Medicina Veterinaria y de Zootecnia, Vol 56, Iss II, Pp 85-94 (2009)
El incremento gradual de la población felina en Colombia y algunos países está acompañado de la aparición de enfermedades que ponen en riesgo la salud animal. El virus de inmunodeficiencia y la leucemia felina son las principales enfermedades re
Externí odkaz:
https://doaj.org/article/66c010f757d34fbca7a24ec1bfd56975
Autor:
Dylan A. Farnsworth, Yusuke Inoue, Fraser D. Johnson, Georgia de Rappard-Yuswack, Daniel Lu, Rocky Shi, Lok In Josephine Ma, Marissa S. Mattar, Romel Somwar, Marc Ladanyi, Arun M. Unni, William W. Lockwood
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-15 (2022)
Abstract MEK inhibitors (MEKi) have limited efficacy in KRAS mutant lung adenocarcinoma (LUAD) patients, and this is attributed to both intrinsic and adaptive mechanisms of drug resistance. While many studies have focused on the former, there remains
Externí odkaz:
https://doaj.org/article/d1bc38b675aa48b9b89c98c59ec5707a
Autor:
Adriana M. Duart, Gabriel S. Mattar, Thais Q. Z. Cesar, Fernando C. Sala, Luis Felipe V. Purquerio
Publikováno v:
Engenharia Agrícola, Vol 43, Iss 1 (2023)
ABSTRACT Tomato cultivation in a protected environment is an important tool for increasing yield, quality, and regularity of production. However, nutrient imbalance in this production system can lead to short-and long-term losses. This study aimed to
Externí odkaz:
https://doaj.org/article/abdb432f8c1047178c8979a3baf5e69e
Autor:
Romel Somwar, Nicolle E. Hofmann, Bryan Smith, Igor Odintsov, Morana Vojnic, Irina Linkov, Ashley Tam, Inna Khodos, Marissa S. Mattar, Elisa de Stanchina, Daniel Flynn, Marc Ladanyi, Alexander Drilon, Ujwal Shinde, Monika A. Davare
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Romel Somwar et al. find that cancer-causing NTRK gene fusions resistant to one form of inhibitor therapy can be resistant to other inhibitor types. Using molecular simulations, they show that some NTRK1 mutations resistant to the type I inhibitor la
Externí odkaz:
https://doaj.org/article/dc4dd666029c45298c0ddd64355c90c2
Autor:
Roger S. Smith, Igor Odintsov, Zebing Liu, Allan Jo-Weng Lui, Takuo Hayashi, Morana Vojnic, Yoshiyuki Suehara, Lukas Delasos, Marissa S. Mattar, Julija Hmeljak, Hillary A. Ramirez, Melissa Shaw, Gabrielle Bui, Alifiani B. Hartono, Eric Gladstone, Siddharth Kunte, Heather Magnan, Inna Khodos, Elisa De Stanchina, Michael P. La Quaglia, Jinjuan Yao, Marick Laé, Sean B. Lee, Lee Spraggon, Christine A. Pratilas, Marc Ladanyi, Romel Somwar
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses the transcriptional regulatory domain of EWSR1 with the DNA-binding domain of WT1, resulting in the oncogenic EWSR1-WT1 fusion protein. T
Externí odkaz:
https://doaj.org/article/7b83f47a6c8e4d5eb829d9ab77a3d402
Autor:
Takuo Hayashi, Igor Odintsov, Roger S. Smith, Kota Ishizawa, Allan J. W. Liu, Lukas Delasos, Christopher Kurzatkowski, Huichun Tai, Eric Gladstone, Morana Vojnic, Shinji Kohsaka, Ken Suzawa, Zebing Liu, Siddharth Kunte, Marissa S. Mattar, Inna Khodos, Monika A. Davare, Alexander Drilon, Emily Cheng, Elisa de Stanchina, Marc Ladanyi, Romel Somwar
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Multi-kinase RET inhibitors, such as cabozantinib and RXDX-105, are active in lung cancer patients with RET fusions; however, the overall response rates to these two drugs are unsatisfactory compared to other targeted therapy paradigms. Moreover, the
Externí odkaz:
https://doaj.org/article/2e7e848718f248f5b1b70bad579df39d
Akademický článek
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Akademický článek
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Autor:
Sudarshan R. Iyer, Igor Odintsov, Adam J. Schoenfeld, Evan Siau, Marissa S. Mattar, Elisa de Stanchina, Inna Khodos, Alexander Drilon, Gregory J. Riely, Marc Ladanyi, Romel Somwar, Monika A. Davare
Publikováno v:
Mol Cancer Res
Targeted therapy of ROS1-fusion-driven non–small cell lung cancer (NSCLC) has achieved notable clinical success. Despite this, resistance to therapy inevitably poses a significant challenge. MYC amplification was present in ∼19% of lorlatinib-res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdaeaf9f244d25c3698502a08bdd256a
https://doi.org/10.1158/1541-7786.mcr-22-0025
https://doi.org/10.1158/1541-7786.mcr-22-0025
Autor:
Alison M. Schram, Igor Odintsov, Madelyn Espinosa-Cotton, Inna Khodos, Whitney J. Sisso, Marissa S. Mattar, Allan J.W. Lui, Morana Vojnic, Sara H. Shameem, Thrusha Chauhan, Jean Torrisi, Jim Ford, Marie N. O'Connor, Cecile A.W. Geuijen, Ron C.J. Schackmann, Jeroen J. Lammerts van Bueren, Ernesto Wasserman, Elisa de Stanchina, Eileen M. O'Reilly, Marc Ladanyi, Alexander Drilon, Romel Somwar
Publikováno v:
Cancer Discov
NRG1 rearrangements are recurrent oncogenic drivers in solid tumors. NRG1 binds to HER3, leading to heterodimerization with other HER/ERBB kinases, increased downstream signaling, and tumorigenesis. Targeting ERBBs, therefore, represents a therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95151a78f3149678f1573205c587eb3
https://doi.org/10.1158/2159-8290.cd-21-1119
https://doi.org/10.1158/2159-8290.cd-21-1119