Zobrazeno 1 - 10
of 906
pro vyhledávání: '"S Markus"'
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background Cerebrospinal fluid (CSF) circulation is essential in removing metabolic wastes from the brain and is an integral component of the glymphatic system. Abnormal CSF circulation is implicated in neurodegenerative diseases. Low b-valu
Externí odkaz:
https://doaj.org/article/0c0357012a914f218dca15aaa1d6dbcf
Autor:
Pablo Iruzubieta, César Augusto Pinheiro Ferreira Alves, Aisha M. Al Shamsi, Gehad ElGhazali, Maha S. Zaki, Lorenzo Pinelli, Diego Lopergolo, Bernard P.H. Cho, Amy A. Jolly, Amna Al Futaisi, Fatema Al-Amrani, Jessica Galli, Elisa Fazzi, Katarina Vulin, Francisco Barajas-Olmos, Holger Hengel, Bayan Mohammed Aljamal, Vahideh Nasr, Farhad Assarzadegan, Michele Ragno, Luigi Trojano, Naomi Meave Ojeda, Arman Çakar, Silvia Bianchi, Francesca Pescini, Anna Poggesi, Amal Al Tenalji, Majid Aziz, Rahema Mohammad, Aziza Chedrawi, Nicola De Stefano, Giovanni Zifarelli, Ludger Schöls, Tobias B. Haack, Adriana Rebelo, Stephan Zuchner, Filiz Koc, Lyn R. Griffiths, Lorena Orozco, Karla García Helmes, Meisam Babaei, Peter Bauer, Won Chan Jeong, Ehsan Ghayoor Karimiani, Miriam Schmidts, Joseph G. Gleeson, Wendy K. Chung, Fowzan Sami Alkuraya, Bita Shalbafan, Hugh S. Markus, Henry Houlden, Reza Maroofian
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105297- (2024)
Summary: Background: NOTCH3 encodes a transmembrane receptor critical for vascular smooth muscle cell function. NOTCH3 variants are the leading cause of hereditary cerebral small vessel disease (SVD). While monoallelic cysteine-involving missense var
Externí odkaz:
https://doaj.org/article/dcf457b6550e45488640bb16d06d46d7
Autor:
Sarah McNeilly, Cameron R. Thomson, Laura Gonzalez-Trueba, Yuan Yan Sin, Alessandra Granata, Graham Hamilton, Michelle Lee, Erin Boland, John D. McClure, Cristina Lumbreras-Perales, Alisha Aman, Apoorva A. Kumar, Marco Cantini, Caglar Gök, Delyth Graham, Yasuko Tomono, Christopher D. Anderson, Yinhui Lu, Colin Smith, Hugh S. Markus, Marc Abramowicz, Catheline Vilain, Rustam Al-Shahi Salman, Manuel Salmeron-Sanchez, Atticus H. Hainsworth, William Fuller, Karl E. Kadler, Neil J. Bulleid, Tom Van Agtmael
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105315- (2024)
Summary: Background: Genetic variants in COL4A1 and COL4A2 (encoding collagen IV alpha chain 1/2) occur in genetic and sporadic forms of cerebral small vessel disease (CSVD), a leading cause of stroke, dementia and intracerebral haemorrhage (ICH). Ho
Externí odkaz:
https://doaj.org/article/d38bd2e3219f479e9d1e302cbcbad3f9
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 15 (2024)
Background Cerebral small‐vessel disease (cSVD) is the leading monogenic cause of stroke. Despite genetic screening in routine diagnosis, many cases remain without a known causative variant. Using a cohort with suspected familial cSVD and whole‐g
Externí odkaz:
https://doaj.org/article/4e09a5ea6a134a539d5b1fd8244492ba
Autor:
Hany Aref, Mohamed Maged, Tamer Roushdy, Hossam Shokri, Eman Hamid, Bernard P. H. Cho, Hugh S. Markus, Mai Fathy, Nevine El Nahas
Publikováno v:
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 60, Iss 1, Pp 1-6 (2024)
Abstract Background Covert cerebral small vessel disease (cCSVD) is associated with many age-related morbidities with little available data regarding the pathophysiology and role of genetics in it. This study aims to investigate the genetic load in a
Externí odkaz:
https://doaj.org/article/4ba9b236607b4e15a0ac6bce712e4738
Autor:
Ellen V Backhouse, Lisa J Woodhouse, Fergus Doubal, Rosalind Brown, Philip M Bath, Terence J Quinn, Thompson Robinson, Hugh S Markus, Richard J McManus, John T O'Brien, David J Werring, Nikola Sprigg, Adrian Parry-Jones, Rhian M Touyz, Steven Williams, Yee-Haur Mah, Hedley Emsley, Joanna M Wardlaw
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100255- (2024)
Introduction: Cognitive decline and mood disorders are two major concerns of people affected by stroke. The extent to which cognition and mood relate to or are independent of stroke severity and post-stroke dependency are unclear. We examined the ass
Externí odkaz:
https://doaj.org/article/269e2a22e8064bf1905bce2fc9fc505b
Autor:
Audrey Low, Maria A Prats-Sedano, James D Stefaniak, Elizabeth McKiernan, Stephen F Carter, Maria-Eleni Dounavi, Elijah Mak, Li Su, Olivia Stupart, Graciela Muniz-Terrera, Karen Ritchie, Craig W Ritchie, Hugh S Markus, John T O'Brien
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100050- (2024)
Externí odkaz:
https://doaj.org/article/de9bf992c4b34557b34ad62e53015ba2
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100083- (2024)
Externí odkaz:
https://doaj.org/article/e7cf8b4458be4d30a8a02447ed6a9e0e
Autor:
Christopher N. Osuafor, Catarina Rua, Andrew D. Mackinnon, Marco Egle, Philip Benjamin, Daniel J. Tozer, Christopher T. Rodgers, Hugh S. Markus
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract 7 Tesla-field-strength (7 T) Magnetic Resonance Imaging allows the small perforating arteries in the brain to be visualised, and this modality may allow visualisation of the arterial pathology in cerebral small vessel disease. Most studies h
Externí odkaz:
https://doaj.org/article/edec8c3a7f954c6e8ed75f0e4f82e61a
Autor:
Lingyan Chen, James E. Peters, Bram Prins, Elodie Persyn, Matthew Traylor, Praveen Surendran, Savita Karthikeyan, Ekaterina Yonova-Doing, Emanuele Di Angelantonio, David J. Roberts, Nicholas A. Watkins, Willem H. Ouwehand, John Danesh, Cathryn M. Lewis, Paola G. Bronson, Hugh S. Markus, Stephen Burgess, Adam S. Butterworth, Joanna M. M. Howson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Mendelian randomization can be used to mimic the effects of protein-targeting drugs in a population of individuals. Here, the authors have identified potential causal proteins for stroke in a two-sample Mendelian randomization framework, providing po
Externí odkaz:
https://doaj.org/article/36ad3820dd294fba8ce25e16910ffecf