Zobrazeno 1 - 10
of 120
pro vyhledávání: '"S Mark Tompkins"'
Autor:
Celine Deffrasnes, Glenn A Marsh, Chwan Hong Foo, Christina L Rootes, Cathryn M Gould, Julian Grusovin, Paul Monaghan, Michael K Lo, S Mark Tompkins, Timothy E Adams, John W Lowenthal, Kaylene J Simpson, Cameron R Stewart, Andrew G D Bean, Lin-Fa Wang
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005478 (2016)
Hendra and Nipah viruses (genus Henipavirus, family Paramyxoviridae) are highly pathogenic bat-borne viruses. The need for high biocontainment when studying henipaviruses has hindered the development of therapeutics and knowledge of the viral infecti
Externí odkaz:
https://doaj.org/article/990aacb096224e819841d625f05bf0c7
Autor:
Zhuo Li, Jon D Gabbard, Scott Johnson, Daniel Dlugolenski, Shannon Phan, S Mark Tompkins, Biao He
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120355 (2015)
H7N9 has caused fatal infections in humans. A safe and effective vaccine is the best way to prevent large-scale outbreaks in the human population. Parainfluenza virus 5 (PIV5), an avirulent paramyxovirus, is a promising vaccine vector. In this work,
Externí odkaz:
https://doaj.org/article/17028ebaab6a44a09fea30e6810b7eef
Autor:
Sean R McMaster, Jon D Gabbard, Dimitris G Koutsonanos, Richard W Compans, Ralph A Tripp, S Mark Tompkins, Jacob E Kohlmeier
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115725 (2015)
Influenza virus is a source of significant health and economic burden from yearly epidemics and sporadic pandemics. Given the potential for the emerging H7N9 influenza virus to cause severe respiratory infections and the lack of exposure to H7 and N9
Externí odkaz:
https://doaj.org/article/2b55b8ced5fc44fc99ba3154422b62c6
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66546 (2013)
Influenza infection stimulates protective host immune responses but paradoxically enhances lung indoleamine 2,3 dioxygenase (IDO) activity, an enzyme that suppresses helper/effector T cells and activates Foxp3-lineage regulatory CD4 T cells (Tregs).
Externí odkaz:
https://doaj.org/article/f60a4ab37ef64c058b96f971700d474a
Autor:
Abhijeet Bakre, Lauren E Andersen, Victoria Meliopoulos, Keegan Coleman, Xiuzhen Yan, Paula Brooks, Jackelyn Crabtree, S Mark Tompkins, Ralph A Tripp
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66796 (2013)
Human protein kinases (HPKs) have profound effects on cellular responses. To better understand the role of HPKs and the signaling networks that influence influenza virus replication, a small interfering RNA (siRNA) screen of 720 HPKs was performed. F
Externí odkaz:
https://doaj.org/article/b2304abccd144c38b83bb7990c0485de
Autor:
Mary J Hauser, Daniel Dlugolenski, Marie R Culhane, David E Wentworth, S Mark Tompkins, Ralph A Tripp
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70251 (2013)
Swine generate reassortant influenza viruses because they can be simultaneously infected with avian and human influenza; however, the features that restrict influenza reassortment in swine and human hosts are not fully understood. Type I and III inte
Externí odkaz:
https://doaj.org/article/af21356b2eeb47d5b6136375b20d79d3
Autor:
Victoria A Meliopoulos, Lauren E Andersen, Paula Brooks, Xiuzhen Yan, Abhijeet Bakre, J Keegan Coleman, S Mark Tompkins, Ralph A Tripp
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37169 (2012)
Influenza A virus causes seasonal epidemics and periodic pandemics threatening the health of millions of people each year. Vaccination is an effective strategy for reducing morbidity and mortality, and in the absence of drug resistance, the efficacy
Externí odkaz:
https://doaj.org/article/fe6297c4d13544b5a96e091bb8225050
Autor:
Mark R Soboleski, Jon D Gabbard, Graeme E Price, Julia A Misplon, Chia-Yun Lo, Daniel R Perez, Jianqiang Ye, S Mark Tompkins, Suzanne L Epstein
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21937 (2011)
The rapid spread of the 2009 H1N1 pandemic influenza virus (pH1N1) highlighted problems associated with relying on strain-matched vaccines. A lengthy process of strain identification, manufacture, and testing is required for current strain-matched va
Externí odkaz:
https://doaj.org/article/ee8d2bd127e54e7fb6eecd59cc506f69
Autor:
Christine M Oshansky, Jennifer A Pickens, Konrad C Bradley, Les P Jones, Geraldine M Saavedra-Ebner, James P Barber, Jackelyn M Crabtree, David A Steinhauer, S Mark Tompkins, Ralph A Tripp
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21183 (2011)
Avian influenza viruses (AIV) are an important emerging threat to public health. It is thought that sialic acid (sia) receptors are barriers in cross-species transmission where the binding preferences of AIV and human influenza viruses are sias α2,3
Externí odkaz:
https://doaj.org/article/b9f6498bd9c04f23864b1423934ee5fc
Autor:
Shelly J. Curran, Emily F. Griffin, Lucas M. Ferreri, Constantinos S. Kyriakis, Elizabeth W. Howerth, Daniel R. Perez, S. Mark Tompkins
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTSince the 1990s, endemic North American swine influenza A viruses (swFLUAVs) contained an internal gene segment constellation, the triple reassortment internal gene (TRIG) cassette. In 2009, the H1N1 pandemic (pdmH1N1) virus spilled back into
Externí odkaz:
https://doaj.org/article/598f5bfdd77840c08ba8d1b37c73acb9