Výsledky vyhledávání - "S M McLachlan"

High affinity, thyroid-specific human autoantibodies displayed on the surface of filamentous phage use V genes similar to other autoantibodies

Autor: S Portolano, S M McLachlan, B Rapoport

Publikováno v: The Journal of Immunology. 151:2839-2851

Autoantibodies to thyroid peroxidase (TPO) are characteristic of thyroid inflammation in autoimmune thyroid disease. We have used the phage display, H and L chain combinatorial cDNA library approach to clone, from thyroid-infiltrating B cells, six ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b48f03d4112174c2b72926e6d79a89de
https://doi.org/10.4049/jimmunol.151.5.2839

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Lack of promiscuity in autoantigen-specific H and L chain combinations as revealed by human H and L chain 'roulette'

Autor: S Portolano, G D Chazenbalk, J S Hutchison, S M McLachlan, B Rapoport

Publikováno v: The Journal of Immunology. 150:880-887

Individual H or L chains from a human autoantibody were used to search for other L or H chains that could form antigen-binding fragments, Fab, with the same specificity. The parent Fab (SP1.2) exhibits high affinity binding for thyroid peroxidase (TP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f34fa4d871f3a2a0a6c6a49378c1978b
https://doi.org/10.4049/jimmunol.150.3.880

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The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease

Autor: S. M. McLachlan

Publikováno v: Endocrine Reviews. 13:192-206

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b45fde6c49deb1038f6379587a32766c
https://doi.org/10.1210/er.13.2.192

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Insight into thyrotropin receptor cleavage by engineering the single polypeptide chain luteinizing hormone receptor into a cleaving, two subunit receptor

Autor: G D, Chazenbalk, S M, McLachlan, C R, Chen, B, Rapoport

Publikováno v: European journal of biochemistry. 268(8)

To gain insight into the thyrotropin hormone (TSH) receptor (TSHR) cleavage, we sought to convert the noncleaving luteinizing hormone (LH) receptor (LHR) into a cleaved, two-subunit molecule. For this purpose, we generated a series of LHR mutants and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30d6e31e964e21cb9754cca7e3e7d6af
https://pubmed.ncbi.nlm.nih.gov/11298743

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A prion-like shift between two conformational forms of a recombinant thyrotropin receptor A-subunit module: purification and stabilization using chemical chaperones of the form reactive with Graves' autoantibodies

Autor: G D, Chazenbalk, S M, McLachlan, P, Pichurin, X M, Yan, B, Rapoport

Publikováno v: The Journal of clinical endocrinology and metabolism. 86(3)

A secreted recombinant TSH receptor (TSHR) ectodomain variant (TSHR-289) neutralizes TSHR autoantibodies in Graves' disease, but is heterogeneous in containing both immunologically active and inactive molecules and is also unstable. We have now purif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d959348f653e7162f54ee2b458fa2c6d
https://pubmed.ncbi.nlm.nih.gov/11238522

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Evidence that cleavage of the thyrotropin receptor involves a 'molecular ruler' mechanism: deletion of amino acid residues 305-320 causes a spatial shift in cleavage site 1 independent of amino acid motif

Autor: K, Tanaka, G D, Chazenbalk, S M, McLachlan, B, Rapoport

Publikováno v: Endocrinology. 141(10)

Some TSH receptors (TSHR) on the cell surface cleave into A and B subunits. Cleavage at upstream Site 1 is followed by the proteolytic excision of an intervening C peptide region terminating at a downstream Site 2. Although present evidence suggests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09b6cc07f259ce1ee93ac3affa27a7c8
https://pubmed.ncbi.nlm.nih.gov/11014210

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On the functional importance of thyrotropin receptor intramolecular cleavage

Autor: G D, Chazenbalk, K, Tanaka, S M, McLachlan, B, Rapoport

Publikováno v: Endocrinology. 140(10)

We examined the relationship between TSH receptor (TSHR) cleavage into two subunits and ligand-independent, constitutive activity characteristic of this receptor. Because of homology to the thrombin receptor-tethered ligand, we focused initially on a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c310d6991b1d0e8c867658f5781002d
https://pubmed.ncbi.nlm.nih.gov/10499506

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