Zobrazeno 1 - 10
of 39
pro vyhledávání: '"S M Lanier"'
Publikováno v:
Acta physiologica (Oxford, England). 204(2)
Beyond the core triad of receptor, Gαβγ and effector, there are multiple accessory proteins that provide alternative modes of signal input and regulatory adaptability to G-protein signalling systems. Such accessory proteins may segregate a signall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d997933b815052f95881af0c0f61b7b6
https://pubmed.ncbi.nlm.nih.gov/21615707
https://pubmed.ncbi.nlm.nih.gov/21615707
Publikováno v:
Journal of Biological Chemistry. 267:9844-9851
alpha 2-Adrenergic receptor (alpha 2-AR) subtypes couple to pertussis toxin (PT)-sensitive G-proteins to elicit both stimulatory and inhibitory cell responses. Signal specificity may be generated by the ability of the receptor subtypes to "recognize"
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bb5d30a6c227154211c7c12e96dfd69
https://doi.org/10.1016/s0021-9258(19)50171-5
https://doi.org/10.1016/s0021-9258(19)50171-5
Publikováno v:
Journal of Biological Chemistry. 267:9852-9857
Cell to cell communication by many hormones and neurotransmitters involves three major entities: receptor (R), G-protein (G), and effector molecule (E). Plasticity in this system is conferred by the existence of each entity as isoforms or closely rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::464bafdf11f4449fc96701d526918268
https://doi.org/10.1016/s0021-9258(19)50172-7
https://doi.org/10.1016/s0021-9258(19)50172-7
Publikováno v:
Journal of Biological Chemistry. 266:10470-10478
alpha 2-Adrenergic receptors (alpha 2-AR) exist as subtypes that are expressed in a tissue-specific manner and differ in 1) their ligand recognition properties, 2) their extent of receptor protein glycosylation, and possible 3) their mechanism of sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a60338e8f8db1ff84f130644cb0cdb1b
https://doi.org/10.1016/s0021-9258(18)99248-3
https://doi.org/10.1016/s0021-9258(18)99248-3
Autor:
M. J. Cismowski, S. M. Lanier
Publikováno v:
Reviews of Physiology Biochemistry and Pharmacology ISBN: 3540281924
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b40eb38f291b292b039a7da1f1a1151
https://doi.org/10.1007/3-540-28217-3_3
https://doi.org/10.1007/3-540-28217-3_3
Autor:
M J, Cismowski, S M, Lanier
Publikováno v:
Reviews of physiology, biochemistry and pharmacology. 155
Heterotrimeric G-proteins are key transducers for signal transfer from outside the cell, mediating signals emanating from cell-surface G-protein coupled receptors (GPCR). Many, if not all, subtypes of heterotrimeric G-proteins are also regulated by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0279f0b8ad3c618f0b6d16e5ff1b493
https://pubmed.ncbi.nlm.nih.gov/16041530
https://pubmed.ncbi.nlm.nih.gov/16041530
Autor:
S. M. Lanier, M. J. Cismowski
Publikováno v:
Reviews of Physiology, Biochemistry and Pharmacology.
Heterotrimeric G-proteins are key transducers for signal transfer from outside the cell, mediating signals emanating from cell-surface G-protein coupled receptors (GPCR). Many, if not all, subtypes of heterotrimeric G-proteins are also regulated by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6de86ddd5ee4f95ddcf6818051c46a8
https://doi.org/10.1007/s10254-005-0042-z
https://doi.org/10.1007/s10254-005-0042-z
Publikováno v:
The Journal of biological chemistry. 275(31)
Utilizing a functional screen in the yeast Saccharomyces cerevisiae we identified mammalian proteins that activate heterotrimeric G-protein signaling pathways in a receptor-independent fashion. One of the identified activators, termed AGS1 (for activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96eda9e471e38ed279fee0bf20250d68
https://pubmed.ncbi.nlm.nih.gov/10840027
https://pubmed.ncbi.nlm.nih.gov/10840027
Autor:
R, Raddatz, S L, Savic, V, Bakthavachalam, J, Lesnick, J R, Jasper, C R, McGrath, A, Parini, S M, Lanier
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(3)
A series of phenoxy-substituted methylimidazoline derivatives were synthesized and used to define the ligand recognition properties of the imidazoline-binding domain (IBD) on monoamine oxidase (MAO)-B and its role in substrate processing. The rank or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1287bdd94fbf4be3836f30d5d7129431
https://pubmed.ncbi.nlm.nih.gov/10688633
https://pubmed.ncbi.nlm.nih.gov/10688633
Autor:
S. M. Lanier
Publikováno v:
The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems ISBN: 9783642630286
Recombinant signaling systems are a basic component of research efforts concerned with the structure and function of members of the superfamily of membrane receptors coupled to heterotrimeric G proteins. The widespread use of such systems in pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::006bfe14fed078a6d6d253be0942bedd
https://doi.org/10.1007/978-3-642-57081-0_12
https://doi.org/10.1007/978-3-642-57081-0_12