Výsledky vyhledávání

Epstein-Barr virus modulates host cell microRNA-194 to promote IL-10 production and B lymphoma cell survival

Autor: A, Harris-Arnold, C P, Arnold, S, Schaffert, O, Hatton, S M, Krams, C O, Esquivel, O M, Martinez

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 15(11)

Epstein-Barr virus (EBV) is a γ-herpesvirus that is linked to the development of posttransplant lymphoproliferative disorder (PTLD) in solid organ recipients. We previously demonstrated that EBV(+) B cell lymphoma cell lines isolated from patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4ba37c18bfe9e981757f54d2c72821c
https://pubmed.ncbi.nlm.nih.gov/26147452

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Involvement of IL-10 in the autonomous growth of EBV-transformed B cell lines

Autor: P R Beatty, S M Krams, O M Martinez

Publikováno v: The Journal of Immunology. 158:4045-4051

Immunocompromised individuals have an increased incidence of EBV-associated B cell lymphomas. The growth factors responsible for the unrestrained proliferation of these lymphomas have not yet been determined. In this study, spontaneous lymphoblastoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4ebbff241676f8b0b4b1096348be484
https://doi.org/10.4049/jimmunol.158.9.4045

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Apoptosis and allograft rejection in the absence of CD8+ T cells

Autor: Y, Ogura, O M, Martinez, J C, Villanueva, J F, Tait, H W, Strauss, J P, Higgins, K, Tanaka, C O, Esquivel, F G, Blankenberg, S M, Krams

Publikováno v: Transplantation. 71(12)

The requirement for cytotoxic T lymphocytes during allograft rejection is controversial. We previously demonstrated that CD8+ T cells are not necessary for allograft rejection or for the induction of apoptosis in rat small intestinal transplantation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c31dacc6bd597dbafbf5b4c4e09af72
https://pubmed.ncbi.nlm.nih.gov/11455265

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Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitis

Autor: C K, Fox, A, Furtwaengler, R R, Nepomuceno, O M, Martinez, S M, Krams

Publikováno v: Liver. 21(4)

Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are two autoimmune diseases with unknown etiologies that primarily target the liver. In both diseases, liver lesions are accompanied by large infiltrates of mononuclear cells. The purpose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a344f0e23835d73acf80f7013500f39
https://pubmed.ncbi.nlm.nih.gov/11454191

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CD30 expression identifies a functional alloreactive human T-lymphocyte subset

Autor: O M, Martinez, J, Villanueva, S, Abtahi, P R, Beatty, C O, Esquivel, S M, Krams

Publikováno v: Transplantation. 65(9)

CD30 is a member of the tumor necrosis factor/nerve growth factor receptor family and has been proposed as a marker of specific cytokine-producing subsets in humans. Previous studies have examined the expression of CD30 on established T helper type 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f6b1a9271db1da10ceab53eed99a133
https://pubmed.ncbi.nlm.nih.gov/9603174

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Human hepatocytes produce an isoform of FAS that inhibits apoptosis

Autor: S M, Krams, C K, Fox, P R, Beatty, S, Cao, J C, Villanueva, C O, Esquivel, O M, Martinez

Publikováno v: Transplantation. 65(5)

Fas (Apo-1/CD95), a member of the tumor necrosis factor receptor family, can mediate apoptosis when engaged by its ligand or by anti-Fas antibody. Fas is expressed by cells of the immune system and by some nonlymphoid tissues. Numerous studies have s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7df3c17bda7fcc3711ed742aa0c7df5d
https://pubmed.ncbi.nlm.nih.gov/9521208

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Production of IL-4 and IL-10 does not lead to immune quiescence in vascularized human organ grafts

Autor: T, Lang, S M, Krams, O M, Martinez

Publikováno v: Transplantation. 62(6)

The delineation of T helper cell subsets into T helper type 1 (Th1) and T helper type 2 (Th2) populations based on the production of specific cytokines has been useful in understanding the regulation and progression of immune-based pathologies. In or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6aeed15d984ceaf1c66b3d235156262d
https://pubmed.ncbi.nlm.nih.gov/8824477

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Expression of cytokines and immune mediators during chronic liver allograft rejection

Autor: M, Hayashi, O M, Martinez, R, Garcia-Kennedy, S, So, C O, Esquivel, S M, Krams

Publikováno v: Transplantation. 60(12)

To determine the immune processes involved in chronic liver allograft rejection (CR) we examined in situ cytokine production in tissue from 15 patients with both clinical and histopathological diagnoses of CR. Total RNA was isolated from liver sample

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c197a949ac274d1295f39d86138efab9
https://pubmed.ncbi.nlm.nih.gov/8545886

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Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis

Autor: O M, Martinez, J C, Villanueva, M E, Gershwin, S M, Krams

Publikováno v: Hepatology (Baltimore, Md.). 21(1)

Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver with unknown etiology. Autoreactive T lymphocytes that infiltrate the liver may play a major role in the bile duct damage that accompanies the disease. We hypothesized that cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ffbca9ec0a120a9b0ef91a6ee1703524
https://pubmed.ncbi.nlm.nih.gov/7806143

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