Zobrazeno 1 - 10
of 45
pro vyhledávání: '"S M Hedrick"'
Autor:
L P Kane, S M Hedrick
Publikováno v:
The Journal of Immunology. 156:4594-4601
We have applied an in vitro system that mimics thymic negative selection to investigate signaling pathways that may be important for the removal of autoreactive cells from the thymus. We sought to more precisely determine the contribution of calcium-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dc7d038e7d2a565d87a712b14bdc9c7
https://doi.org/10.4049/jimmunol.156.12.4594
https://doi.org/10.4049/jimmunol.156.12.4594
Autor:
J M Penninger, E Timms, A Shahinian, A Jezo-Bremond, H Nishina, J Ionescu, S M Hedrick, T W Mak
Publikováno v:
The Journal of Immunology. 155:3847-3855
Interactions between CD28/CTLA-4 on T cells and CD80 (B7.1) and CD86 (B7.2) counter receptors provide crucial costimulatory signals for TCR-alpha beta+ lymphocytes. To test the role of CD28 in thymic development and activation of TCR-gamma delta+ T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1e6ac5cb526aa2cf047a3564228e6c0
https://doi.org/10.4049/jimmunol.155.8.3847
https://doi.org/10.4049/jimmunol.155.8.3847
Publikováno v:
The Journal of Immunology. 154:5706-5714
We have produced transgenic mice that express rearranged T cell Ag receptor gamma and delta transgenes in the alpha beta lineage of thymocytes. Thymi in these mice contain normal numbers of CD4+CD8+ cells that express low levels of the TCR-gamma delt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::727c628c21635ff3cc6c234adee52388
https://doi.org/10.4049/jimmunol.154.11.5706
https://doi.org/10.4049/jimmunol.154.11.5706
Gamma delta T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides
Publikováno v:
The Journal of Immunology. 153:3051-3058
Although T cells expressing the gamma delta Ag receptor (gamma delta cells) have been found in all organisms with lymphoid systems, little is understood about their immunologic function. It is known that T cells that express the alpha beta Ag recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c44980cd1e71c03ea9aa68e11d32e6
https://doi.org/10.4049/jimmunol.153.7.3051
https://doi.org/10.4049/jimmunol.153.7.3051
Publikováno v:
The Journal of Immunology. 148:3342-3353
The Ag receptor (TCR) on T lymphocytes has been shown to be specific for foreign antigenic peptides bound to MHC-encoded molecules. During T cell differentiation in the thymus this same TCR mediates the recognition of MHC molecules in the absence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2c6e969001f88c01fec71763081cb0a
https://doi.org/10.4049/jimmunol.148.11.3342
https://doi.org/10.4049/jimmunol.148.11.3342
Publikováno v:
The Journal of Immunology. 148:2363-2369
The present studies examined resting and activated murine gamma/delta T lymphocytes, in vitro and in vivo, for surface expression of FcR. Polyclonal gamma/delta TCR+ lymphocytes selectively grown from the spleen and intestine of normal mice did not e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d3ca8d5b20175f9077c82a1e27dd02a
https://doi.org/10.4049/jimmunol.148.8.2363
https://doi.org/10.4049/jimmunol.148.8.2363
Autor:
H R Bhayani, S M Hedrick
Publikováno v:
The Journal of Immunology. 146:1093-1098
Allelic variants of MHC molecules expressed on cells of the thymus affect the selection and the specificity of the T cell repertoire. The selection is based on either the direct recognition by the TCR of the MHC molecules, or the recognition of a com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24042594050a753f35cc2fc70eacc491
https://doi.org/10.4049/jimmunol.146.4.1093
https://doi.org/10.4049/jimmunol.146.4.1093
Publikováno v:
The Journal of Immunology. 144:1127-1135
Nine independent pigeon cytochrome c-specific T cell clones were analyzed by using a panel of antigenic peptide analogs presented in association with three allelic IE-encoded MHC glycoproteins. Eight of the T cell clones expressed a TCR composed of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc660480632deabd06de98ca63e0889
https://doi.org/10.4049/jimmunol.144.3.1127
https://doi.org/10.4049/jimmunol.144.3.1127
Autor:
L L, Sharp, S M, Hedrick
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(12)
The development of T cells results in a concordance between the specificity of the TCR for MHC class I and class II molecules and the expression of CD8 and CD4 coreceptors. Based on analogy to simple metazoan models of organ development and lineage c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d6795b6798b94ed45f7cb713d613f7c
https://pubmed.ncbi.nlm.nih.gov/10586054
https://pubmed.ncbi.nlm.nih.gov/10586054
B cell tolerance to a minor, but not to a major, antigenic surface of the self antigen, cytochrome c
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(6)
To study B cell tolerance to the mitochondrial protein cytochrome c (CYT), the B cell response to pigeon CYT (PCC) was examined in mice transgenic for PCC. PCC was coupled to OVA to provide T cell help, since PCC-specific T cells in PCC-transgenic mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bff10bd55a48cbcccc578b038eecb48c
https://pubmed.ncbi.nlm.nih.gov/9743344
https://pubmed.ncbi.nlm.nih.gov/9743344