Zobrazeno 1 - 10
of 56
pro vyhledávání: '"S M Hanash"'
Publikováno v:
The Journal of Immunology. 159:1303-1309
DNA methylation, a mechanism modifying gene expression, is mediated in part by the enzyme DNA methyltransferase. Reduced levels of T cell DNA methyltransferase have been observed in lupus-like diseases, and increased levels have been reported in mali
Autor:
S. M. Hanash, Shawkat Q. Lafi, Mohamad Al-Katib, Essam Raweily, Nabil Hailat, Ziad M. Bataineh, Mahmoud Aqel
Publikováno v:
International Journal of Pharmacognosy. 33:16-20
Nigella sativa L. Ranunclaceae is a spicy plant that has bronchodilatory, hypotensive, antibacterial and immunopotentiating activities. Its effect on intracellular signals has not been investigated. Jurkat T leukemia cells were treated with the volat
Autor:
D. M. Lubman, D. A. Gage, Philip C. Andrews, John R. Strahler, Pao-Chi Liao, Yang Kao Wang, S. M. Hanash, J. Allison
Publikováno v:
Journal of Biological Chemistry. 268:14269-14277
Op18 is a widely expressed, cell cycle-regulated, phosphoprotein involved in signal transduction of a variety of stimuli. In actively proliferating Jurkat T cells which express Op18 at high level, phorbol 12-myristate 13-acetate (PMA) treatment induc
Autor:
J-Y, Li, R, Kuick, R C, Thompson, D E, Misek, Y-M, Lai, Y-Q, Liu, B-X, Chai, S M, Hanash, I, Gantz
Publikováno v:
Journal of neuroendocrinology. 17(6)
The arcuate nucleus of the hypothalamus is a primary site for sensing blood borne nutrients and hormonal messengers that reflect caloric status. To identify novel energy homeostatic genes, we examined RNA extracts from the microdissected arcuate nucl
Publikováno v:
Proteomics. 1(11)
Megakaryocytes undergo an unusual cell cycle during differentiation that results in polyploidy through largely unknown mechanism(s). It has been shown that serine phosphorylation of oncoprotein 18 (Op18) is required for cell cycle progression specifi
Autor:
S M, Hanash
Publikováno v:
Current opinion in molecular therapeutics. 3(6)
Global profiling of gene expression at the genomic level using DNA microarrays and at the protein level using a variety of technologies have followed separate paths. Studies of gene expression for several types of tumors, using DNA microarrays, have
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(11)
We used a proteomics-based approach to identify tumor proteins that elicit a humoral response in breast carcinoma and that may occur as circulating antigens.The breast cell line SUM-44 was used as a source of tumor cell proteins for two-dimensional P
Autor:
D S, Rickman, M P, Bobek, D E, Misek, R, Kuick, M, Blaivas, D M, Kurnit, J, Taylor, S M, Hanash
Publikováno v:
Cancer research. 61(18)
Astrocytomas are heterogeneous intracranial glial neoplasms ranging from the highly aggressive malignant glioblastoma multiforme (GBM) to the indolent, low-grade pilocytic astrocytoma. We have investigated whether DNA microarrays can identify gene ex
Autor:
K, Wimmer, X X, Zhu, B J, Lamb, R, Kuick, P, Ambros, H, Kovar, D, Thoraval, A, Elkahloun, P, Meltzer, S M, Hanash
Publikováno v:
Medical and pediatric oncology. 36(1)
Amplification of the oncogene MYCN in neuroblastoma has been found to correlate with aggressive tumour growth and is used as a predictor of clinical outcome. The MYCN amplicon is known to involve coamplification of extensive DNA regions. Therefore it
Publikováno v:
Arthritis and rheumatism. 44(2)
Previous studies have shown that inhibiting T cell DNA methylation causes a lupus-like disease by modifying gene expression. T cells from patients with lupus exhibit diminished levels of DNA methyltransferase (MTase) enzyme activity, hypomethylated D