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Dynorphin A toxicity in striatal neurons via an α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor mechanism

Autor: S M Goebel, Kurt F. Hauser, Robin J. Goody, K M Martin

Publikováno v: Neuroscience. 116:807-816

Dynorphin A (1-17) is an endogenous opioid peptide that is antinociceptive at physiological concentrations, but in excess can elicit a number of pathological effects. Both κ-opioid and N -methyl- d -aspartate receptor antagonists modulate dynorphin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0339f14320cd476fbfef5c1a1f1182
https://doi.org/10.1016/s0306-4522(02)00563-8

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Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation

Autor: Daniel Hirschberg, Tomas Bergman, Zoya Marinova, Kurt F. Hauser, Indrapal N. Singh, Georgy Bakalkin, Pamela E. Knapp, S M Goebel, Tatjana Yakovleva, Robin J. Goody, K M Martin

Publikováno v: Neuroscience. 122(4)

Dynorphin A (1-17), an endogenous opioid neuropeptide, can have pathophysiological consequences at high concentrations through actions involving glutamate receptors. Despite evidence of excitotoxicity, the basic mechanisms underlying dynorphin-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f086a4015012c92bda73bd3003813783
https://pubmed.ncbi.nlm.nih.gov/14643768

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