Výsledky vyhledávání - "S M, Thacher"

Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents

Autor: A M, Standeven, S M, Thacher, Y D, Yuan, M, Escobar, V, Vuligonda, R L, Beard, R A, Chandraratna

Publikováno v: Biochemical pharmacology. 62(11)

Hypertriglyceridemia is a major side-effect of retinoid therapy in humans. We previously reported that agonists for the retinoic acid receptors (RARs), but not the retinoid X receptors (RXRs), elevate serum triglycerides in male Fischer rats, and tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72bc1f83f2380f5587ac40712f4f3635
https://pubmed.ncbi.nlm.nih.gov/11728386

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Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition

Autor: M I, Dawson, J H, Park, G, Chen, W, Chao, L, Dousman, N, Waleh, P D, Hobbs, L, Jong, L, Toll, X, Zhang, J, Gu, A, Agadir, J L, Merchant, L, Bai, A K, Verma, S M, Thacher, R A, Chandraratna, B, Shroot, D L, Hill

Publikováno v: International journal of cancer. 91(1)

Evaluation of retinoic acid receptor (RAR) subtype-selective alpha and gamma agonists and antagonists and a retinoid X receptor (RXR) class-selective agonist for efficacy at inhibiting both induction of ornithine decarboxylase (ODC) by the tumor prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4111c22c8af1055bff6e5b468f455613
https://pubmed.ncbi.nlm.nih.gov/11149424

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Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes

Autor: S M, Thacher, S, Nagpal, E S, Klein, T, Arefieg, G, Krasinski, D, DiSepio, C, Agarwal, A, Johnson, R L, Eckert, R A, Chandraratna

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(4)

Retinoids are important regulators of epithelial differentiation. AGN 193109 is a high-affinity antagonist and inverse agonist for the nuclear retinoic acid receptors (RARs). Paradoxically, both AGN 193109 and retinoid agonists inhibit the expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af30393fc8e3b4745f8332983e07ca04
https://pubmed.ncbi.nlm.nih.gov/10319995

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Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation

Autor: S M, Thacher, A M, Standeven, J, Athanikar, S, Kopper, O, Castilleja, M, Escobar, R L, Beard, R A, Chandraratna

Publikováno v: The Journal of pharmacology and experimental therapeutics. 282(2)

Retinoid induction of epidermal hyperplasia was investigated in hairless mice with synthetic ligands for the retinoic acid (RAR) and retinoid X (RXR) nuclear receptors. Induction of hyperplasia by all-trans retinoic acid and the RAR-specific retinoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7eba9ec447c8b3f172e7f5074bd622a4
https://pubmed.ncbi.nlm.nih.gov/9262312

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Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis

Autor: S, Nagpal, S M, Thacher, S, Patel, S, Friant, M, Malhotra, J, Shafer, G, Krasinski, A T, Asano, M, Teng, M, Duvic, R A, Chandraratna

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 7(12)

Retinoids down-regulate the expression of metalloproteinases, cytokines, and other genes involved in cell proliferation and inflammation. Tazarotene (AGN 190168), a retinoic acid receptor (RAR)-specific retinoid, is effective in the treatment of psor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36e36face7f743d341d2f4f5cb879bc3
https://pubmed.ncbi.nlm.nih.gov/8959347

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Structural analysis of the predicted coiled-coil rod domain of the cytoplasmic bullous pemphigoid antigen (BPAG1). Empirical localization of the N-terminal globular domain-rod boundary

Autor: H Y, Tang, A F, Chaffotte, S M, Thacher

Publikováno v: The Journal of biological chemistry. 271(16)

The bullous pemphigoid antigen BPAG1 is required for keratin filament linkage to the hemidesmosome, an adhesion complex in epithelial basal cells. BPAG1 structural organization is similar to the intermediate filament-associated proteins desmoplakin I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3ccd1d134eb546459a526b49877f594
https://pubmed.ncbi.nlm.nih.gov/8621649

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Cross-linked envelope-related markers for squamous differentiation in human lung cancer cell lines

Autor: M L, Levitt, A F, Gazdar, H K, Oie, H, Schuller, S M, Thacher

Publikováno v: Cancer research. 50(1)

Lung carcinoma cell lines were analyzed in culture and in nude mouse xenograft for both morphological appearance and expression of specific proteins that participate in cross-linked envelope formation during normal squamous cell terminal differentiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95eb8aff47950b40fc71040589773eb3
https://pubmed.ncbi.nlm.nih.gov/1967140

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Retinoic acid and substratum regulate the differentiation of rabbit tracheal epithelial cells into squamous and secretory phenotype. Morphological and biochemical characterization

Autor: A M, Jetten, A R, Brody, M A, Deas, G E, Hook, J I, Rearick, S M, Thacher

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 56(6)

In this paper we show that the expression of the squamous differentiated phenotype and mucosecretory phenotype by cultured rabbit tracheal epithelial cells can be regulated by substratum and the presence of retinoic acid. Cells grown on a type I coll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49c65a006cb58ce71fbef2dcb780ae5c
https://pubmed.ncbi.nlm.nih.gov/2439773

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Retinoid suppression of transglutaminase activity and envelope competence in cultured human epidermal carcinoma cells. Hydrocortisone is a potent antagonist or retinyl acetate but not retinoic acid

Autor: S M, Thacher, E L, Coe, R H, Rice

Publikováno v: Differentiation; research in biological diversity. 29(1)

Growth of SCC-13 squamous carcinoma cultures in the presence of retinoids considerably reduced the expression of two differentiation markers, the cellular capability to form cross-linked envelopes, and the enzyme transglutaminase required for cross-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc479b0271b876d6641edb2e43efd344
https://pubmed.ncbi.nlm.nih.gov/2862088

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