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CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice

Autor: J, Sun, S, Nam, C S, Lee, B, Li, D, Coppola, A D, Hamilton, Q P, Dou, S M, Sebti

Publikováno v: Cancer research. 61(4)

The ubiquitin proteasome system is responsible for the proteolysis of important cell cycle and apoptosis-regulatory proteins. In this paper we report that the dipeptidyl proteasome inhibitor, phthalimide-(CH2)8CH-(cyclopentyl) CO-Arg(NO2)-Leu-H (CEP1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df0e653c480c44dd50d5daeb1c854d9e
https://pubmed.ncbi.nlm.nih.gov/11245420

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Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS

Autor: E, Cohen-Jonathan, R J, Muschel, W, Gillies McKenna, S M, Evans, G, Cerniglia, R, Mick, D, Kusewitt, S M, Sebti, A D, Hamilton, A, Oliff, N, Kohl, J B, Gibbs, E J, Bernhard

Publikováno v: Radiation research. 154(2)

Successful radiosensitization requires that tumor cells become more radiosensitive without causing an equivalent reduction in the survival of cells of the surrounding normal tissues. Since tumor cell radiosensitivity can be influenced by RAS oncogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e5d95574a27208373ea5105d4620f6f
https://pubmed.ncbi.nlm.nih.gov/10931682

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Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I

Autor: J, Rosenbloom, B, Saitta, S, Gaidarova, N, Sandorfi, J C, Rosenbloom, W R, Abrams, A D, Hamilton, S M, Sebti, U, Kucich, S A, Jimenez

Publikováno v: Arthritis and rheumatism. 43(7)

To examine the effects of specific inhibition of geranylgeranyl transferase I on the expression of types I and III collagen genes in normal and systemic sclerosis (SSc) dermal fibroblasts in vitro.Fibroblasts from 2 normal subjects and 4 SSc patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41f5af952dc5bd398818cd77253c671a
https://pubmed.ncbi.nlm.nih.gov/10902768

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The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity

Autor: J, Sun, Y, Qian, Z, Chen, J, Marfurt, A D, Hamilton, S M, Sebti

Publikováno v: The Journal of biological chemistry. 274(11)

The geranylgeranyltransferase I inhibitor GGTI-298 has recently been shown to arrest human tumor cells in the G1 phase of the cell cycle, induce apoptosis, and inhibit tumor growth in nude mice. In the present manuscript, we provide a possible mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::825f65ae6b2c61812d336e4a9532d820
https://pubmed.ncbi.nlm.nih.gov/10066746

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Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes

Autor: E J, Bernhard, W G, McKenna, A D, Hamilton, S M, Sebti, Y, Qian, J M, Wu, R J, Muschel

Publikováno v: Cancer research. 58(8)

The influence of activated ras oncogenes on the sensitivity of human tumor cells to killing by radiation has been an unresolved question in radiobiology. We have examined this question by measuring the radiation sensitivity of human tumor cell lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77b8ac8677c33f19090b07290f1f3d52
https://pubmed.ncbi.nlm.nih.gov/9563495

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Inhibition of Ras prenylation: a signaling target for novel anti-cancer drug design

Autor: E C, Lerner, A D, Hamilton, S M, Sebti

Publikováno v: Anti-cancer drug design. 12(4)

The cancer-causing activity of Ras requires the prenylation of a cysteine fourth from its carboxyl terminus. Rational design of peptidomimetics of the carboxyl terminal tetrapeptide prenylation site on Ras resulted in pharmacological agents capable o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3c40dd5f963b9da6f6d87118eb0d603
https://pubmed.ncbi.nlm.nih.gov/9199657

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GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells

Autor: K, Miquel, A, Pradines, J, Sun, Y, Qian, A D, Hamilton, S M, Sebti, G, Favre

Publikováno v: Cancer research. 57(10)

The mechanism by which the geranylgeranyltransferase I inhibitor GGTI-298 and the farnesyltransferase inhibitor FTI-277 inhibit human tumor growth is not known. Herein, we demonstrate that in the human lung adenocarcinoma A549 cells, GGTI-298 induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8bc9da69eb14f31b5d2ca82ad28b814
https://pubmed.ncbi.nlm.nih.gov/9157972

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Bleomycin

Autor: J S, Lazo, S M, Sebti

Publikováno v: Cancer chemotherapy and biological response modifiers. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84e8871b15c144ebd0b1191b443cf6f0
https://pubmed.ncbi.nlm.nih.gov/9551207

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