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Hormonal regulation of radioiodide uptake activity and Na+/I- symporter expression in mammary glands

Autor: J Y, Cho, R, Léveillé, R, Kao, B, Rousset, A F, Parlow, W E, Burak, E L, Mazzaferri, S M, Jhiang

Publikováno v: The Journal of clinical endocrinology and metabolism. 85(8)

The observation that radioiodide uptake (RAIU) activity, mediated by the Na+/I- symporter (NIS), is significantly increased in lactating breast suggests that RAIU and NIS expression in mammary gland are modulated by hormones involved in active lactat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5007387fb79ea42fec04ca29ffa3e03f
https://pubmed.ncbi.nlm.nih.gov/10946907

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Monoclonal antibodies against the human sodium iodide symporter: utility for immunocytochemistry of thyroid cancer

Autor: John C. Morris, S C Ziesmer, John R. Goellner, S M Jhiang, Elizabeth R. Bergert, Maria R. Castro, Patrick C. Roche, T G Beito

Publikováno v: The Journal of endocrinology. 163(3)

The recent cloning of the thyroidal protein that is responsible for iodide transport, the sodium iodide symporter (hNIS), has made possible studies designed to characterize its structure, function and expression in thyroidal tissues. Using a mannose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e3e19048329be24e826da4e95d7ebd
https://pubmed.ncbi.nlm.nih.gov/10588823

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Thyroid carcinomas in RET/PTC transgenic mice

Autor: S M, Jhiang, J Y, Cho, T L, Furminger, J E, Sagartz, Q, Tong, C C, Capen, E L, Mazzaferri

Publikováno v: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 154

The RET/PTC oncogene, a rearranged form of the RET proto-oncogene, has been found to be associated with human papillary thyroid carcinomas. To investigate whether RET/PTC causes papillary thyroid carcinoma, we generated a transgenic mouse model of pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ce8e617a3e570120a7f64e7c8d9fba6
https://pubmed.ncbi.nlm.nih.gov/10027006

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High prevalence of T354P sodium/iodide symporter gene mutation in Japanese patients with iodide transport defect who have heterogeneous clinical pictures

Autor: S, Kosugi, Y, Sato, A, Matsuda, Y, Ohyama, K, Fujieda, H, Inomata, T, Kameya, O, Isozaki, S M, Jhiang

Publikováno v: The Journal of clinical endocrinology and metabolism. 83(11)

A missense and loss of function mutation of the Na+/I- symporter (NIS) gene, T354P [Thr354--Pro (ACA--CCA)], was found in the homozygous state in two unrelated Japanese patients with iodide transport defect. In this study we have identified the homoz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58f57870066e6b7bdb72df89db3b90b7
https://pubmed.ncbi.nlm.nih.gov/9814502

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Promoter characterization of the human Na+/I- symporter

Autor: K Y, Ryu, Q, Tong, S M, Jhiang

Publikováno v: The Journal of clinical endocrinology and metabolism. 83(9)

The Na+/I- symporter (NIS) is the plasma membrane protein that mediates active iodide uptake into thyroid follicular cells. To understand the molecular mechanisms of human NIS (hNIS) gene regulation, the 2-kb immediate 5'-flanking region of hNIS was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8fbfd6c9712deaf4eaa77f1a377b83d
https://pubmed.ncbi.nlm.nih.gov/9745437

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Thyroid-stimulating hormone promotes growth of thyroid carcinomas in transgenic mice with targeted expression of the ret/PTC1 oncogene

Autor: J E, Sagartz, S M, Jhiang, Q, Tong, C C, Capen

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 76(3)

Thyroid carcinomas from mice bearing a thyroid-targeted ret/PTC1 oncogene were studied for responsiveness to endogenous thyroid-stimulating hormone (TSH) to evaluate the effect of TSH on tumor progression. Mice of both sexes were maintained for eithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d46e7d5737a0af8ea9afd7351861b9d6
https://pubmed.ncbi.nlm.nih.gov/9121113

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Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene

Autor: Q, Tong, Y, Li, P A, Smanik, L J, Fithian, S, Xing, E L, Mazzaferri, S M, Jhiang

Publikováno v: Oncogene. 10(9)

PTC-1, the predominant form of PTC oncogene in human papillary thyroid carcinoma, encodes a fusion protein containing the N-terminus of H4 (D10S170) fused 5' to the ret tyrosine kinase domain. Accordingly, the PTC-1 expression is driven by the H4 gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ceb5d323c5526639db944f9586563f6
https://pubmed.ncbi.nlm.nih.gov/7753554

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Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct

Autor: L, Perlaky, B C, Valdez, R K, Busch, R G, Larson, S M, Jhiang, W W, Zhang, M, Brattain, H, Busch

Publikováno v: Cancer research. 52(2)

The human nucleolar antigen p120 was detected with an anti-p120 monoclonal antibody in most human malignant tumors but not in most resting human tissues (J. W. Freeman et al., Cancer Res., 48: 1244-1251, 1988) and has been used as a prognostic tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09599247b9ce41b7a41188d24bf45799
https://pubmed.ncbi.nlm.nih.gov/1728415

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