Zobrazeno 1 - 10 of 95 pro vyhledávání: '"S M, Ismail"'
1
Akademický článek
Multi-epitope peptide vaccines targeting dengue virus serotype 2 created via immunoinformatic analysis
Autor: Radwa N. Morgan, Nasser S. M. Ismail, Mohammad Y. Alshahrani, Khaled M. Aboshanab
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract The Middle East has witnessed a greater spread of infectious Dengue viruses, with serotype 2 (DENV-2) being the most prevalent form. Through this work, multi-epitope peptide vaccines against DENV-2 that target E and nonstructural (NS1) prote
Externí odkaz: https://doaj.org/article/62965c4cde2547b1b71d6d9eb1618030
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2
Akademický článek
Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents
Autor: Rania S. M. Ismail, Ahmed M. El Kerdawy, Dalia H. Soliman, Hanan H. Georgey, Nagwa M. Abdel Gawad, Andrea Angeli, Claudiu T. Supuran
Publikováno v: BMC Chemistry, Vol 17, Iss 1, Pp 1-23 (2023)
Abstract An optimization strategy was adopted for designing and synthesizing new series of 2-oxindole conjugates. Selected compounds were evaluated for their antiproliferative effect in vitro against NCI-60 cell lines panel, inhibitory effect on carb
Externí odkaz: https://doaj.org/article/521f95dcb807414ba9837f65d560d43a
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3
Akademický článek
Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity
Autor: Asmaa A. Mandour, Ibrahim F. Nassar, Mohammed T. Abdel Aal, Mahmoud A. E. Shahin, Wael A. El-Sayed, Maghawry Hegazy, Amr Mohamed Yehia, Ahmed Ismail, Mohamed Hagras, Eslam B. Elkaeed, Hanan M. Refaat, Nasser S. M. Ismail
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1957-1973 (2022)
Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established for their antitumor activity via CDK2 inhibition. In this re
Externí odkaz: https://doaj.org/article/1e6ab14dd8874e4886ee7d210668ea2f
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4
Akademický článek
Medicinal attributes of pyridine scaffold as anticancer targeting agents
Autor: Esraa Ali Mohamed, Nasser S. M. Ismail, Mohamed Hagras, Hanan Refaat
Publikováno v: Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract Background The heterocyclic compounds particularly pyridine displayed clinical and biological implementation. Pyridine scaffolds have been detected in most relevant drug molecules that included pyridine provided a great possibility for treat
Externí odkaz: https://doaj.org/article/11343823743540ac910a7749e4b3f1ab
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5
Akademický článek
Evaluation of the Effect of Elite Jojoba Lines on the Chemical Properties of their Seed Oil
Autor: Nahla A. Awad, Mohamed Eliraq, Emad H. El-Bassel, Ahmed S. M. Ismail, Yasser S. G. Abd El-Aziz, Mohamed S. Gawish, Reda M. Y. Zewail, Rokayya Sami, Ebtihal Khojah, Uguru Hilary, Maalem H. Al-Moalem, Khaled Sayed-Ahmed
Publikováno v: Molecules, Vol 27, Iss 12, p 3904 (2022)
Jojoba oil (JO) extracted from seeds has outstanding properties, including anti-inflammatory, antioxidant, and antibacterial activities, and can be stored forlong periodsof time. The unique properties of jojoba oil depend on its chemical composition;
Externí odkaz: https://doaj.org/article/9856f3877192489482b53ff7c5108481
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6
Structural, magnetic, and optical properties of ZnFe2O4/RO (RO = CdO, NiO, Ga2O3, SnO2, and TiO2) nanocomposites
Autor: Kh. Roumaih, S. M. Ismail, Sh. Labib, Ahmed Helal
Publikováno v: Journal of Materials Science. 58:7948-7967
The sol–gel method is used to prepare the nanocomposites ZF/RO (ZF = ZnFe2O4, RO = CdO, NiO, Ga2O3, SnO2, and TiO2). The XRD showed that the ZF/RO nanocomposite' crystal structure contained many phases, and the lattice properties and crystal size o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5212b9c0b11c6cfca1b1614ed3143e0a
https://doi.org/10.1007/s10853-023-08539-8
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7
Akademický článek
Potential Role of Colchicine in Combating COVID-19 Cytokine Storm and Its Ability to Inhibit Protease Enzyme of SARS-CoV-2 as Conferred by Molecular Docking Analysis
Autor: Noha A. Kamel, Nasser S. M. Ismail, Ibrahim S. Yahia, Khaled M. Aboshanab
Publikováno v: Medicina, Vol 58, Iss 1, p 20 (2021)
Despite the advance in the management of Coronavirus disease 2019 (COVID-19), the global pandemic is still ongoing with a massive health crisis. COVID-19 manifestations may range from mild symptoms to severe life threatening ones. The hallmark of the
Externí odkaz: https://doaj.org/article/6781c5e892bf4f689f1866ae0743852d
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9
Akademický článek
Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity
Autor: Adel A.-H. Abdel-Rahman, Amira K. F. Shaban, Ibrahim F. Nassar, Dina S. EL-Kady, Nasser S. M. Ismail, Samy F. Mahmoud, Hanem M. Awad, Wael A. El-Sayed
Publikováno v: Molecules, Vol 26, Iss 13, p 3923 (2021)
New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (1). The chloro, met
Externí odkaz: https://doaj.org/article/1fe734c131f04ee1a2f38d4c319345c7
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