Zobrazeno 1 - 10
of 13
pro vyhledávání: '"S M, Glaser"'
Autor:
D E Yelton, M J Rosok, G Cruz, W L Cosand, J Bajorath, I Hellström, K E Hellström, W D Huse, S M Glaser
Publikováno v:
The Journal of Immunology. 155:1994-2004
We have increased up to 65-fold the avidity of BR96, a mAb recognizing Lewis Y (Le(y))-related Ags expressed on the surface of many human carcinomas. Libraries of mutations in the complementarity-determining regions (CDRs) of BR96 were constructed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f5a1e59bd1307df10ba5d913cbd1e74
https://doi.org/10.4049/jimmunol.155.4.1994
https://doi.org/10.4049/jimmunol.155.4.1994
Publikováno v:
The Journal of Immunology. 150:3086-3090
The anti-ld response developed by cynomolgus monkeys to the humanized anti-Tac antibody was analyzed by using 12 humanized anti-Tac variants differing in V region structure. The majority of the monkey response was directed against idiotopes composed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4d121a54d1a5c22d99dd796f4c69494
https://doi.org/10.4049/jimmunol.150.7.3086
https://doi.org/10.4049/jimmunol.150.7.3086
Autor:
W D Huse, T J Stinchcombe, S M Glaser, L Starr, M MacLean, K E Hellström, I Hellström, D E Yelton
Publikováno v:
The Journal of Immunology. 149:3914-3920
We describe the application of a novel filamentous phage vector system suitable for efficient screening and production of F(ab) antibody fragments. The vector system can concurrently produce free F(ab) fragments and F(ab) displayed on the surface of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c7f06e41aa531c8d28ff0776206e54
https://doi.org/10.4049/jimmunol.149.12.3914
https://doi.org/10.4049/jimmunol.149.12.3914
Publikováno v:
The Journal of Immunology. 149:3903-3913
A novel codon-based mutagenesis procedure is described that allows rapid and efficient modification of antibody amino acid sequences expressed as F(ab) fragments in M13. The procedure succeeded in generating a library of mutations in the complementar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8efbaad99aa11fbe1de695aed043de92
https://doi.org/10.4049/jimmunol.149.12.3903
https://doi.org/10.4049/jimmunol.149.12.3903
Publikováno v:
Molecular and Cellular Biology. 10:1873-1881
We have examined the import and intramitochondrial localization of the precursor to yeast cytochrome c oxidase subunit Va, a protein of the mitochondrial inner membrane. The results of studies on the import of subunit Va derivatives carrying altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1661f3bf3c3a2c3bb045300d442fe8e7
https://doi.org/10.1128/mcb.10.5.1873-1881.1990
https://doi.org/10.1128/mcb.10.5.1873-1881.1990
Publikováno v:
Molecular and Cellular Biology. 10:1873-1881
We have examined the import and intramitochondrial localization of the precursor to yeast cytochrome c oxidase subunit Va, a protein of the mitochondrial inner membrane. The results of studies on the import of subunit Va derivatives carrying altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43ae60712f080ef67b9bcd6b6930eb98
https://doi.org/10.1128/mcb.10.5.1873
https://doi.org/10.1128/mcb.10.5.1873
Autor:
D E, Yelton, M J, Rosok, G, Cruz, W L, Cosand, J, Bajorath, I, Hellström, K E, Hellström, W D, Huse, S M, Glaser
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 155(4)
We have increased up to 65-fold the avidity of BR96, a mAb recognizing Lewis Y (Le(y))-related Ags expressed on the surface of many human carcinomas. Libraries of mutations in the complementarity-determining regions (CDRs) of BR96 were constructed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30c08c34f43e73eaed9bcbdee7712f15
https://pubmed.ncbi.nlm.nih.gov/7636250
https://pubmed.ncbi.nlm.nih.gov/7636250
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 150(7)
The anti-ld response developed by cynomolgus monkeys to the humanized anti-Tac antibody was analyzed by using 12 humanized anti-Tac variants differing in V region structure. The majority of the monkey response was directed against idiotopes composed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4106eefc6617a28efc370ad0ba43e71e
https://pubmed.ncbi.nlm.nih.gov/8454876
https://pubmed.ncbi.nlm.nih.gov/8454876
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 149(12)
A novel codon-based mutagenesis procedure is described that allows rapid and efficient modification of antibody amino acid sequences expressed as F(ab) fragments in M13. The procedure succeeded in generating a library of mutations in the complementar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa02ea99efcb5aa8f59fb145993cbed7
https://pubmed.ncbi.nlm.nih.gov/1460281
https://pubmed.ncbi.nlm.nih.gov/1460281
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 149(8)
The genetically engineered "humanized" anti-Tac antibody (HAT) has been shown to bind the p55 chain of the human IL-2R with an affinity close to that of the murine anti-Tac. Although the HAT molecule contains all six mouse CDR, it was not known which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5e12d11ed29a5b648d0acc474bc77ca
https://pubmed.ncbi.nlm.nih.gov/1401898
https://pubmed.ncbi.nlm.nih.gov/1401898