Výsledky vyhledávání

Current insights into the 'antiphospholipid' syndrome: clinical, immunological, and molecular aspects

Autor: D A, Kandiah, A, Sali, Y, Sheng, E J, Victoria, D M, Marquis, S M, Coutts, S A, Krilis

Publikováno v: Advances in immunology. 70

Advances in defining the target antigen(s) for the autoantibodies in the APS highlight the inadequacies of the current classification of these autoantibodies into anticardiolipin and LA antibodies. The discovery that beta 2GPI is the target antigen f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7387026a7acb0817c6ebc88a3d1fc1c
https://pubmed.ncbi.nlm.nih.gov/9755344

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Assessing the solvency and financial strength of a general insurance company

Autor: P. D. Smith, C. D. Daykin, S. M. Coutts, E. R. F. Devitt, G. B. Hey, D. I. W. Reynolds, G. D. Bernstein

Publikováno v: Journal of the Institute of Actuaries. 114:227-325

After reviewing some general issues concerning solvency and the problems associated with establishing the financial strength of a general insurance company using the traditional balance sheet concept, the authors put forward an emerging costs approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6cbd9407203e926992e7b00a464c4d9
https://doi.org/10.1017/s0020268100019077

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Purification of rat peritoneal mast cells: occupation of IgE-receptors by IgE prevents loss of the receptors

Autor: S M Coutts, R E Nehring, N U Jariwala

Publikováno v: The Journal of Immunology. 124:2309-2315

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::211cd67d05ea85c0b13ba55becffd109
https://doi.org/10.4049/jimmunol.124.5.2309

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Direct experimental evidence for kinetic proofreading in amino acylation of tRNAIle

Autor: T. Yamane, V. Yue, S M Coutts, John J. Hopfield

Publikováno v: Proceedings of the National Academy of Sciences. 73:1164-1168

Kinetic proofreading is a reaction scheme with a structure more complicated than that of Michaelis kinetics, which leads to a proofreading for errors in the recognition of a correct substrate by an enzyme. We have measured the stoichiometry between A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6b23632ded65de66961adc1103b593
https://doi.org/10.1073/pnas.73.4.1164

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Motor insurance rating, an actuarial approach

Autor: S. M. Coutts

Publikováno v: Journal of the Institute of Actuaries. 111:87-148

This paper is largely based on a Ph.D. thesis (Coutts (1983)) and provides an actuarial approach to the technical aspects of motor insurance premium rating, where equal weights are given to both the practical and statistical elements of the problem.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::659133ac82cf15c14bd0038cffc17c73
https://doi.org/10.1017/s0020268100041561

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The Solvency of a General Insurance Company in Terms of Emerging Costs

Autor: C. D. Daykin, G. D. Bernstein, S. M. Coutts, E. R. F. Devitt, G. B. Hey, D. I. W. Reynolds, P. D. Smith

Publikováno v: ASTIN Bulletin. 17:85-132

The authors challenge the traditional balance sheet concept of the solvency of a general insurance company and put forward an emerging costs concept, which enables the true nature of the assets and liabilities to be taken into account, including thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7b180de10117e09dd80a42bab42ce85
https://doi.org/10.2143/ast.17.1.2014985

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Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). I. Effect on release of histamine in vitro from rat peritoneal mast cells, guinea pig lung slices and human basophils

Autor: A, Khandwala, S M, Coutts, I, Weinryb

Publikováno v: International archives of allergy and applied immunology. 70(4)

Nylidrin (RHC 3432-A) has been investigated for its antiallergic activity in three in vitro models. Nylidrin was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69f8763837d9ee6f84014f4f2ea68596
https://pubmed.ncbi.nlm.nih.gov/6186608

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Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). II. A lack of correlation between inhibition of mediator release and levels of cyclic AMP

Autor: S M, Coutts, A, Khandwala, I, Weinryb

Publikováno v: International archives of allergy and applied immunology. 70(4)

Nylidrin hydrochloride has weak beta-adrenergic agonist properties with rat mast cells, and shows synergy with 3-isobutyl-1-methylxanthine (IBMX) in raising intracellular cAMP in purified mast cells; both of these properties can be blocked by dl-prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbf10ca9867bfc621ea571b045220efd
https://pubmed.ncbi.nlm.nih.gov/6186609

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