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pro vyhledávání: '"S M, Behar"'
Autor:
S M, Behar, S A, Porcelli
Publikováno v:
Current topics in microbiology and immunology. 314
CD1 has been clearly shown to function as a microbial recognition system for activation of T cell responses, but its importance for mammalian protective responses against infections is still uncertain. The function of the group 1 CD1 isoforms, includ
Autor:
C C, Dascher, K, Hiromatsu, J W, Naylor, P P, Brauer, K A, Brown, J R, Storey, S M, Behar, E S, Kawasaki, S A, Porcelli, M B, Brenner, K P, LeClair
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(10)
CD1 is a family of cell-surface molecules capable of presenting microbial lipid Ags to specific T cells. Here we describe the CD1 gene family of the guinea pig (Cavia porcellus). Eight distinct cDNA clones corresponding to CD1 transcripts were isolat
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(8)
CD1 is an MHC class I-like molecule that has been conserved throughout mammalian evolution. Unlike MHC class I molecules, CD1 can present unique nonprotein antigens to T cells. The murine CD1 locus contains two highly homologous genes, CD1d1 and CD1d
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(1)
Human and murine T cells that specifically recognize CD1d and produce IL-4 and IFN-gamma play a role in immunoregulation and tumor rejection. In the mouse, most CD1d1-reactive T cells described express an invariant Valpha14-Jalpha281 TCR associated w
Autor:
M S, Vincent, K, Roessner, T, Sellati, C D, Huston, L H, Sigal, S M, Behar, J D, Radolf, R C, Budd
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(10)
Lyme arthritis synovial fluid contains a large proportion of gamma delta T cells that proliferates upon stimulation with the causative spirochete, Borrelia burgdorferi. A panel of Borrelia-reactive gamma delta T cell clones was derived from synovial
Autor:
S M, Behar, G M, Chertow
Publikováno v:
The Journal of rheumatology. 25(3)
We describe a 59-year-old woman with diabetes and chronic asthma treated with prednisone and methotrexate who developed chronic olecranon bursitis caused by Candida lusitaniae. Infection, especially with unusual microbial pathogens, should be conside
Publikováno v:
Arthritis and rheumatism. 41(3)
Previously, we showed that 15-20% of patients with rheumatoid arthritis (RA) have oligoclonal expansions of peripheral blood CD8+ T cells expressing T cell receptors encoded by the V(alpha)12 (AV12S1) gene. To better understand the significance of th
Autor:
E M, Beckman, A, Melián, S M, Behar, P A, Sieling, D, Chatterjee, S T, Furlong, R, Matsumoto, J P, Rosat, R L, Modlin, S A, Porcelli
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(7)
Previous studies suggest that CD1 is a family of Ag-presenting molecules distantly related to those encoded by the MHC. However, of the four known human CD1 proteins, only CD1b has been shown to restrict Ag-specific T cell responses. In this study, w
Autor:
S M, Behar, S A, Porcelli
Publikováno v:
Arthritis and rheumatism. 38(4)
Publikováno v:
Nature. 372(6507)
Major histocompatibility complex (MHC) class I and class II molecules bind immunogenic peptides and present them to lymphocytes bearing the alpha beta T-cell antigen receptor (TCR). An analogous antigen-presenting function also has been proposed for