Zobrazeno 1 - 10
of 13
pro vyhledávání: '"S Lucy, Hind"'
Autor:
and Martin J. Slater, J. Ed Robinson, Martin R. Johnson, Gail Mills, S. Lucy Hind, Tony J. Pateman, Tracy Jane Redfern, David M. Andrews, Paul Spencer Jones, Naimisha Trivedi, Angela Patikis, Michael C. Barnes, Mike D. Dowle
Publikováno v:
Organic Letters. 5:4631-4634
[reaction: see text] In this, the second of two Letters, the optimization of the pyrrolidine-5,5-trans-lactam template (exemplified by 1a) as a mechanism-based inhibitor of hepatitis C NS3/4A protease is described. "Right Box" analysis of cassette do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38887863b133f85a34524a3302dbc5da
https://doi.org/10.1021/ol035827n
https://doi.org/10.1021/ol035827n
Autor:
S. Lucy Hind, Gail Mills, Katrina Jane GlaxoSmithKline Wareing, David M. Andrews, Paul Spencer Jones, Martin John Slater, Naimisha Trivedi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1657-1660
Using the pyrrolidine-5,5- trans -lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 2b , with a spiro-cyclobutyl P1 substituent and an isopropyl carbonyl substituent at the lactam ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ca2f183ce0887cf0e5733b68a8ba7ef
https://doi.org/10.1016/s0960-894x(03)00274-9
https://doi.org/10.1016/s0960-894x(03)00274-9
Autor:
Naimisha Trivedi, Martin R. Johnson, Angela Patikis, David M. Andrews, Paul Spencer Jones, S. Lucy Hind, Mike D. Dowle, Martin John Slater, J. Ed Robinson, Helene M. Chaignot, Coomber Ba, Tony J. Pateman, Gail Mills
Publikováno v:
European Journal of Medicinal Chemistry. 38:339-343
The pyrrolidine-5,5-trans-lactam template was used to design small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease displaying potent activity in the replicon cell-based assay. The activity of this series is not dependent upon its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76fe97b2add8009252258f35d3b2874
https://doi.org/10.1016/s0223-5234(03)00050-3
https://doi.org/10.1016/s0223-5234(03)00050-3
Publikováno v:
Tetrahedron Letters. 41:6897-6900
The indole bis-oxazole 2 , a potential intermediate for the synthesis of the marine natural product diazonamide A 1 , has been synthesised, and attempts to construct the model macrocycle (ring B) 3 are also described; in both approaches rhodium carbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9a57f9439f76f6e76196b1370099576
https://doi.org/10.1016/s0040-4039(00)01120-5
https://doi.org/10.1016/s0040-4039(00)01120-5
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :591-600
A new method for the synthesis of oxazoles, and in particular chiral non-racemic oxazoles derived from amino acids, has been developed. Thus, rhodium(II) catalysed reaction of diazocarbonyl compounds 6 and 11 in the presence of amides 8 and 10 result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebe2454448c2352fa47ac9c9a4ab7b1e
https://doi.org/10.1039/a704093h
https://doi.org/10.1039/a704093h
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe59024e7a5588742956dc1c2b972bf3
https://doi.org/10.1002/chin.200014087
https://doi.org/10.1002/chin.200014087
Autor:
Veronique Gouverneur, Christopher David Edlin, Alison Judith Redgrave, Steven P. Nolan, S. Lucy Hind, Catherine A. Slinn
Publikováno v:
ChemInform. 35
Ru- and Mo-based catalysts can be used in ring closing metathesis (RCM) reactions to synthesise cyclic phosphines protected as their borane complexes. The compatibility of the Schrock Mo-catalyst and the N-heterocyclic carbene Ru-catalysts with this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b8f578df071a9e7bf463613c31c9a4
https://doi.org/10.1002/chin.200413134
https://doi.org/10.1002/chin.200413134
Autor:
Catherine A, Slinn, Alison J, Redgrave, S Lucy, Hind, Chris, Edlin, Steven P, Nolan, Veronique, Gouverneur
Publikováno v:
Organicbiomolecular chemistry. 1(21)
Ru- and Mo-based catalysts can be used in ring closing metathesis (RCM) reactions to synthesise cyclic phosphines protected as their borane complexes. The compatibility of the Schrock Mo-catalyst and the N-heterocyclic carbene Ru-catalysts with this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::278a2fd0593f8f92cd23bde9c6232cf9
https://pubmed.ncbi.nlm.nih.gov/14649914
https://pubmed.ncbi.nlm.nih.gov/14649914
Autor:
Martin John Slater, David M. Andrews, Paul Spencer Jones, Naimisha Trivedi, Gail Mills, S. Lucy Hind, Katrina Jane GlaxoSmithKline Wareing
Publikováno v:
ChemInform. 34
Using the pyrrolidine-5,5- trans -lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 2b , with a spiro-cyclobutyl P1 substituent and an isopropyl carbonyl substituent at the lactam ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f173d4df8b44cd4cfc397d0c5f990a8
https://doi.org/10.1002/chin.200338096
https://doi.org/10.1002/chin.200338096
Publikováno v:
ChemInform. 31
The indole bis-oxazole 2 , a potential intermediate for the synthesis of the marine natural product diazonamide A 1 , has been synthesised, and attempts to construct the model macrocycle (ring B) 3 are also described; in both approaches rhodium carbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c18cbc5e1b271748733630a0141297f
https://doi.org/10.1002/chin.200045204
https://doi.org/10.1002/chin.200045204